KATIA BILHAR SCAPINI
Projetos de Pesquisa
Unidades Organizacionais
LIM/59 - Laboratório de Biologia Celular, Hospital das Clínicas, Faculdade de Medicina
15 resultados
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conferenceObject Inspiratory muscle training and aerobic training present similar effects on blood pressure and cardiovascular autonomic control in hypertensive patients(2015) FERREIRA, J.; SCAPINI, K. B.; SANTOS, F.; COELHO, O.; SOUZA, S. B.; LAGO, P. Dal; CONSOLIM-COLOMBO, F. M.; IRIGOYEN, M. C.- Interval and continuous aerobic exercise training similarly increase cardiac function and autonomic modulation in infarcted mice(2017) ABAD, Cesar Cavinato Cal; NASCIMENTO, Ademir Manuel do; SANTOS, Leandro Eziquiel dos; FIGUEROA, Diego; RAMONA, Pamella; SARTORI, Michele; SCAPINI, Katie B.; ALBUQUERQUE, Oscar; MORAES-SILVA, Ivana Cinthya; COELHO-JUNIOR, Hello Jose; RODRIGUES, Bruno; MOSTARDA, Cristiano Teixeira; ANGELIS, Katia De; IRIGOYEN, Maria ClaudiaThe present study aimed to compare the effects of moderate-intensity continuous and high-intensity interval exercise training (ET) on exercise tolerance, cardiac morphometry and function, hemodynamic, and cardiac autonomic modulation in myocardial infarcted mice. Wild-type mice (WT) were divided into four groups: sedentary WT (S); WT myocardium infarction sedentary (IS); WT myocardium infarction underwent to moderate-intensity continuous ET (MICT), and WT myocardium infarction underwent to high-intensity interval ET (MIIT). After 60 days of descending coronary artery ligation, moderate-intensity continuous ET consisted of running at 60% of maximum, while the high-intensity interval training consisted of eight sprints of 4 min at 80% of maximum and a 4-min recovery at 40% of maximum. Both exercises were performed 1 hr a day, 5 days a week, during 8 weeks. Results demonstrated that IS showed elevated exercise tolerance, as well as decreased hemodynamic and heart function, and autonomic control. On the other hand, both programs of ET were equally effective to increase all parameters, without further differences between the groups. In conclusion, the results of the present study showed that myocardial infarction leads to damage in both investigated strains and the two types of physical exercise attenuated the major impairments provoked by myocardial infarction in exercise tolerance, cardiac structure, cardiac function, hemodynamic and cardiac autonomic modulation.
- Cardiovascular autonomic dysfunction in non-obese diabetic mice(2013) MORAES, Oscar A.; COLUCCI, Juliana A.; SOUZA, Leandro E.; SCAPINI, Katia B.; MORAES-SILVA, Ivana C.; MOSTARDA, Cristiano; ANGELIS, Katia De; CASARINI, Dulce E.; IRIGOYEN, Maria ClaudiaIt is known that diabetes is associated with autonomic dysfunction; however, data about autonomic function in non-obese diabetic mice (NOD) remain scarce. We evaluated the autonomic profile of NOD mice. Female mice, 24-28 week old, were divided in two groups: NOD (n = 6) and control (n = 6, Swiss mice). NOD mice with glycemia >= 300 mg/dl were used. Heart rate variability (HRV) and arterial pressure variability (APV) in time and frequency domains, symbolic analysis of heart rate (HR) and baroreflex sensitivity were evaluated. HR and arterial pressure (AP) were similar between the groups; however, HRV (total variance of RR interval: NOD = 21.07 +/- 3.75 vs. C = 42.02 +/- 6.54 ms(2)) and the vagal modulation index RMSSD were lower in NOD group (4.01 +/- 032 vs. 8.28 +/- 0.97 ms). Moreover, the absolute and normalized low-frequency (LF) components were also enhanced in NOD (normalized = 61.0 +/- 4.0%) as compared to control mice (normalized = 20.0 +/- 4.0%). Both the absolute and normalized high-frequency (HF) components were lower in NOD (normalized = 39.0 +/- 4.0%) when compared to the control group (normalized = 80.0 +/- 4.0). In the symbolic analysis the 0V pattern, an indication of sympathetic activity, was higher in NOD and 2LV pattern, an indication of parasympathetic activity, was lower in the NOD than in the control group. Both bradycardic and tachycardic responses were decreased in NOD (3.01 +/- 0.72 vs. 4.54 +/- 0.36 bpm/mm Hg and 2.49 +/- 031 vs. C = 3.43 +/- 033 bpm/mm Hg) when compared to the control group. Correlation analysis showed negative correlations between vagal indexes (RMSSD, %HF and 2LV) and glycemic levels. In conclusion, NOD mice develop severe diabetes correlated with autonomic dysfunction.
- Interval and continuous aerobic exercise training similarly increase cardiac function and autonomic modulation in infarcted mice (vol 13, pg 257, 2017)(2017) ABAD, Cesar Cavinato Cal; NASCIMENTO, Ademir Manuel do; SOUZA, Leandro Eziquiel de; FIGUEROA, Diego; RAMONA, Pamella; SARTORI, Michele; SCAPINI, Katia B.; ALBUQUERQUE, Oscar; MORAES-SILVA, Ivana Cinthya; COELHO-JUNIOR, Helio Jose; RODRIGUES, Bruno; MOSTARDA, Cristiano Teixeira; ANGELIS, Katia De; IRIGOYEN, Maria Claudia
conferenceObject Loaded breathing exercise increases cardiovascular sympathetic modulation acutely in patients with essential hypertension(2015) FERREIRA, J.; SCAPINI, K. B.; SANTOS, F.; LAGO, P. Dal; CONSOLIM-COLOMBO, F. M.; IRIGOYEN, M. C.conferenceObject Erythropoietin promotes cardiac autonomic dysfunction and does not modify end diastolic pressure in a myocardial infarction model in rats(2015) ALBUQUERQUE, O.; SOUZA, L. E.; SCAPINI, K. B.; MOSTARDA, C.; CONSOLIM-COLOMBO, F. M.; IRIGOYEN, M. C.- Effects of testosterone on lean mass gain in elderly men: systematic review with meta-analysis of controlled and randomized studies(2015) NETO, Walter Krause; GAMA, Eliane Florencio; ROCHA, Leandro Yanase; RAMOS, Carla Cristina; TAETS, Wagner; SCAPINI, Katia Bilhar; FERREIRA, Janaina B.; RODRIGUES, Bruno; CAPERUTO, EricoThe objective of this study was to evaluate the effects of steroid anabolic androgenic hormones use on lean mass gain in elderly men through a systematic review with a meta-analysis of randomized controlled studies. We systematically searched PubMed database until 4th October 2013. We included randomized placebo-controlled trials (RCT) that studied testosterone replacement therapy in men over 60 years of age, with total testosterone levels <= 550 ng/dl, observing gains in weight, lean mass tissue and fat mass as outcome. We excluded duplicated studies, studies which mixed men and women, and studies using weak androgens such as dehydroepiandrosterone or androstenedione. The initial search yielded 2681 articles, of which 26 were selected for full text analysis. In the end, 11 studies were included. However, 3 studies were not included in the meta-analysis. Meta-analysis showed that mean weight increased (lean mass), ranging from 1.65 (95 % CI, 1.61-1.69) to 6.20 (95 % CI, 5.22-7.18) kg, although it was heterogeneous (I-2=98 %). Effect estimate was 3.59 [2.38-4.81]. Androgen therapy decreased fat mass; effect estimate was -1.78 [-2.57, -0.99] that analysis had also a high level of heterogeneity (I-2=81%). The results suggest that testosterone replacement therapy is able to increase muscle mass in elderly men and that is affected by the time that the treatment is carried out and the method of administration of the drug.
- Cardiac autonomic dysfunction in chronic stroke women is attenuated after submaximal exercise test, as evaluated by linear and nonlinear analysis(2015) FRANCICA, Juliana Valente; BIGONGIARI, Aline; MOCHIZUKI, Luis; SCAPINI, Katia Bilhar; MORAES, Oscar Albuquerque; MOSTARDA, Cristiano; CAPERUTO, Erico Chagas; IRIGOYEN, Maria Claudia; ANGELIS, Katia De; RODRIGUES, BrunoBackground: We evaluated cardiac autonomic modulation in women with chronic ischemic stroke (at least 4 years post-stroke) at rest and in response to submaximal exercise test. Methods: Fourteen post-stroke women (S group) and 10 healthy women (C group) participated in this study. Autonomic modulation (using linear and nonlinear analysis), blood pressure and metabolic variables at rest were evaluated immediately after the exercise test and during the recovery period (20 min). All participants underwent submaximal exercise test on cycle ergometer with gas analysis. Results: At rest, the S group displayed higher lactate concentration, systolic (SBP) and diastolic blood pressure (DBP) values when compared to C group. Furthermore, the S group had lower heart rate variability (HRV) in time domain (SDNN: S = 30 +/- 5 vs. 40 +/- 8 ms; rMSSD: S = 14 +/- 2 vs. C = 34 +/- 3 ms), decreased high frequency band of pulse interval (S = 8.4 +/- 2 vs. 33.1 +/- 9 %) and 2V pattern of symbolic analysis (S = 17.3 +/- 1 vs. 30 +/- 3 %) (both indicators of cardiac vagal modulation) when compared to C group. Immediately after exercise, S group presented higher values of lactate, SBP, DBP and double product when compared to C group, as well as decreased heart rate recovery (HRR) measured at the first, second and third minutes. At recovery time, all HRV parameters in time and frequency domains improved in the S group; however, HF band remained lower when compared to C group. Conclusions: After the exercise test, women with chronic stroke presented reduced heart rate variability, reduced cardiac vagal modulation, as well as reduced HRR, while displayed an improvement of heart rate variability and cardiac vagal modulation when compared to their baseline. These results reinforce the importance of a physically active lifestyle for cardiovascular autonomic disorders observed in chronic stroke women.
- Low intensity resistance training improves systolic function and cardiovascular autonomic control in diabetic rats(2014) MOSTARDA, Cristiano T.; RODRIGUES, Bruno; MORAES, Oscar Albuquerque de; MORAES-SILVA, Ivana C.; ARRUDA, Paula Barros Olinto; CARDOSO, Ruymar; SCAPINI, Katia Bilhar; SANTOS, Fernando dos; ANGELIS, Katia De; IRIGOYEN, Maria ClaudiaAims: We evaluated the effects of low intensity resistance training (RT) on left ventricular (LV) function, baroreflex sensitivity (BRS), and cardiovascular autonomic control of streptozotocin-induced diabetic rats. Methods: Male Wistar rats were divided into (n = 8 each group): sedentary control (SC), trained control (TC), sedentary diabetic (SD), and trained diabetic (TD). Trained groups underwent low intensity RT (40%-50% 1 repetition maximum) for 10 weeks. Echocardiographic evaluation, arterial pressure (AP), heart rate (HR), BRS, and autonomic measurements were performed. Results: Diabetes induced an increase in glycemia and a reduction in body weight in diabetics when compared with control animals. Diabetic rats displayed cardiac dysfunction, reduced systolic AP and HR, impaired BRS and autonomic derangement when compared to control rats. RT improved ejection fraction (SD: 68% +/- 1.3% vs. TD: 75% +/- 3.0%) and velocity of circumferential fiber shortening (SD: 0.32 +/- 0.02 vs. TD: 0.40 +/- 0.01 circ/seg.10(-4)). Trained diabetic rats presented increased AP (+10.2%), HR (+10.4%), and BRS after RT protocol. Conclusions: Low intensity RT induced an increase in systolic function in diabetic rats. This may be due to positive LV remodeling and BRS improvement, which may have played an important role in the attenuation of hemodynamic impairment and cardiac autonomic neuropathy in streptozotocin-diabetic rats.
conferenceObject CARDIOVASCULAR AND METABOLIC EFFECTS OF EXERCISE TRAINING IN HIGH-FAT DIET-FED OVARIECTOMIZED MICE: COMPARISON BETWEEN MODERATE INTENSITY CONTINUOUS VS. HIGH INTENSITY INTERVAL TRAINING(2018) NASCIMENTO-CARVALHO, Bruno; SANTOS, Adriano; SANTOS, Nicolas Costa; ASSIS, Abel Pereira; IRIGOYEN, Maria-Claudia Costa; ANGELIS, Katia De; CAPERUTO, Erico Chagas; SCAPINI, Katia Bilhar; SANCHES, Iris Callado