MARIA TERESA CORREIA CALEIRO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
19 resultados
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Agora exibindo 1 - 10 de 19
- Pregnancy outcomes in mixed connective tissue disease: a multicentre study(2019) RADIN, Massimo; SCHREIBER, Karen; CUADRADO, Maria Jose; CECCHI, Irene; ANDREOLI, Laura; FRANCESCHINI, Franco; CALEIRO, Teresa; ANDRADE, Danieli; GIBBONE, Elena; KHAMASHTA, Munther; BUYON, Jill; IZMIRLY, Peter; AGUIRRE, Maria Angeles; BENEDETTO, Chiara; ROCCATELLO, Dario; MAROZIO, Luca; SCIASCIA, SavinoObjectives. In this study we aimed to investigate foetal and maternal pregnancy outcomes from a large multicentre cohort of women diagnosed with MCTD and anti-U1RNP antibodies. Methods. This multicentre retrospective cohort study describes the outcomes of 203 pregnancies in 94 consecutive women ever pregnant who fulfilled the established criteria for MCTD with confirmed U1RNP positivity. Results. The foetal outcomes in 203 pregnancies were as follows: 146 (71.9%) live births, 38 (18.7%) miscarriages (first trimester pregnancy loss of <12 weeks gestation), 18 (8.9%) stillbirths (pregnancy loss after 20 weeks gestation) and 11 (5.4%) cases with intrauterine growth restriction. Maternal pregnancy outcomes were as follows: 8 (3.9%) developed pre-eclampsia, 2 (0.9%) developed eclampsia, 31 (15.3%) developed gestational hypertension and 3 (1.5%) developed gestational diabetes. Women with MCTD and aPL and pulmonary or muscular involvement had worse foetal outcomes compared with those without. Moreover, we report a case of complete congenital heart block (0.45%) and a case of cutaneous neonatal lupus, both born to a mother with positive isolated anti-U1RNP and negative anti-Ro/SSA antibodies. Conclusion. In our multicentre cohort, women with MCTD had a live birth rate of 72%. While the true frequency of heart block associated with anti-U1RNP remains to be determined, this study might raise the consideration of echocardiographic surveillance in this setting. Pregnancy counselling should be considered in women with MCTD.
- Immunogenicity and safety of the 2009 non-adjuvanted influenza A/H1N1 vaccine in a large cohort of autoimmune rheumatic diseases(2011) SAAD, Carla G. S.; BORBA, Eduardo F.; AIKAWA, Nadia E.; SILVA, Clovis A.; PEREIRA, Rosa M. R.; CALICH, Ana Luisa; MORAES, Julio C. B.; RIBEIRO, Ana C. M.; VIANA, Vilma S. T.; PASOTO, Sandra G.; CARVALHO, Jozelio F.; FRANCA, Ivan L. A.; GUEDES, Lissiane K. N.; SHINJO, Samuel K.; SAMPAIO-BARROS, Percival D.; CALEIRO, Maria T.; GONCALVES, Celio R.; FULLER, Ricardo; LEVY-NETO, Mauricio; TIMENETSKY, Maria do Carmo S.; PRECIOSO, Alexander R.; BONFA, EloisaBackground Despite the WHO recommendation that the 2010-2011 trivalent seasonal flu vaccine must contain A/California/7/2009/H1N1-like virus there is no consistent data regarding its immunogenicity and safety in a large autoimmune rheumatic disease (ARD) population. Methods 1668 ARD patients (systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), ankylosing spondylitis (AS), systemic sclerosis, psoriatic arthritis (PsA), Behcet's disease (BD), mixed connective tissue disease, primary antiphospholipid syndrome (PAPS), dermatomyositis (DM), primary Sjogren's syndrome, Takayasu's arteritis, polymyositis and Granulomatosis with polyangiitis (Wegener's) (GPA)) and 234 healthy controls were vaccinated with a non-adjuvanted influenza A/California/7/2009(H1N1) virus-like strain flu. Subjects were evaluated before vaccination and 21 days post-vaccination. The percentage of seroprotection, seroconversion and the factor increase in geometric mean titre (GMT) were calculated. Results After immunisation, seroprotection rates (68.5% vs 82.9% p < 0.0001), seroconversion rates (63.4% vs 76.9%, p < 0.001) and the factor increase in GMT (8.9 vs 13.2 p < 0.0001) were significantly lower in ARD than controls. Analysis of specific diseases revealed that seroprotection significantly reduced in SLE (p < 0.0001), RA (p < 0.0001), PsA (p=0.0006), AS (p=0.04), BD (p=0.04) and DM (p=0.04) patients than controls. The seroconversion rates in SLE (p < 0.0001), RA (p < 0.0001) and PsA (p=0.0006) patients and the increase in GMTs in SLE (p < 0.0001), RA (p < 0.0001) and PsA (p < 0.0001) patients were also reduced compared with controls. Moderate and severe side effects were not reported. Conclusions The novel recognition of a diverse vaccine immunogenicity profile in distinct ARDs supports the notion that a booster dose may be recommended for diseases with suboptimal immune responses. This large study also settles the issue of vaccine safety. (ClinicalTrials.gov #NCT01151644)
bookPart Doença Mista do Tecido Conectivo(2016) CALEIRO, Maria Teresa Correia; MIOSSI, RenataconferenceObject High Resolution Computer Tomography Analysis Of A Cohort Of Mixed Connective Tissue Disease (mctd) Patients: 10 Years Of Follow-Up(2013) KAWANO-DOURADO, L.; DIAS, O. M.; KAY, F.; GRIPP, T.; GOMES, P.; CALEIRO, M.; KAIRALLA, R.; CARVALHO, C. R. R.bookPart Doença mista do tecico conectivo(2021) MIOSSI, Renata; CALEIRO, Maria Teresa Correia- Position article and guidelines 2018 recommendations of the Brazilian Society of Rheumatology for the indication, interpretation and performance of nailfold capillaroscopy(2019) KAYSER, Cristiane; BREDEMEIER, Markus; CALEIRO, Maria Teresa; CAPOBIANCO, Karina; FERNANDES, Tatiana Melo; FONTENELE, Sheila Marcia de Araujo; FREIRE, Eutilia; LONZETTI, Lilian; MIOSSI, Renata; SEKIYAMA, Juliana; MUELLER, Carolina de SouzaNailfold capillaroscopy (NFC) is a reproducible, simple, low-cost, and safe imaging technique used for morphological analysis of nail bed capillaries. It is considered to be extremely useful for the investigation of Raynaud's phenomenon and for the early diagnosis of systemic sclerosis (SSc). The capillaroscopic pattern typically associated with SSc, scleroderma (""SD"") pattern, is characterized by dilated capillaries, microhemorrhages, avascular areas and/or capillary loss, and distortion of the capillary architecture. The aim of these recommendations is to provide orientation regarding the relevance of NFC, and to establish a consensus on the indications, nomenclature, the interpretation of NFC findings and the technical equipments that should be used. These recommendations were formulated based on a systematic literature review of studies included in the database MEDLINE (PubMed) without any time restriction.
conferenceObject Alterations in Nailfold Capillaroscopy in Childhood-Onset Systemic Lupus Erythematosus: The Role of Disease Activity in a Prospective(2016) AIKAWA, Nadia E.; SOUSA, Luiz; PEREZ, Mariana O.; LUPPINO-ASSAD, Ana Paula; PEREIRA, Rosa M. R.; CALEIRO, Maria TeresabookPart Síndrome Antifosfolípide(2016) ANDRADE, Danieli Castro Oliveira de; CALEIRO, Maria Teresa Correia; LOPES, Michelle Remião Ugolini- Association of arterial events with the coexistence of metabolic syndrome and primary antiphospholipid syndrome(2012) RODRIGUES, Carlos Ewerton Maia; BONFA, Eloisa; CALEIRO, Maria Teresa Correia; VENDRAMINI, Margarete B.; BUENO, Cleonice; LOPES, Jaqueline B.; CARVALHO, Jozelio Freire deObjective Metabolic syndrome (MetS) is highly prevalent in rheumatic diseases and is recognized as a new independent cardiovascular risk factor. This study was undertaken to determine the clinical significance of MetS in patients with primary antiphospholipid syndrome (APS). Methods Seventy-one primary APS patients and 73 age- and sex-matched healthy controls were included. Serum samples were tested for lipid profile, Lp(a), glucose, insulin, thyroid-stimulating hormone, free T4, erythrocyte sedimentation rate, C-reactive protein level, and uric acid. MetS was defined by the International Diabetes Federation criteria, and insulin resistance was established using the homeostasis model assessment index. Results The prevalence of MetS was 33.8%, and further comparison between primary APS patients with and without MetS revealed that the former had a higher frequency of arterial events (79.2% versus 42.6%; P = 0.003), angina (29.2% versus 2.1%; P = 0.002), and positive lupus anticoagulant antibody (95.8% versus 76.6%; P = 0.049). In addition, primary APS patients with MetS, as expected, had a higher prevalence of cardiovascular risk factors. On multivariate analysis, only MetS was independently associated with arterial events in primary APS. Conclusion Coexistence of primary APS and MetS seems to identify a subgroup of patients with higher risk of arterial events, suggesting that MetS may aggravate existing endothelial abnormalities of primary APS.
conferenceObject 10-Year Follow-Up Of Pulmonary Function In Mixed Connective Tissue Disease(2013) KAWANO-DOURADO, L.; DIAS, O. M.; KAY, F. U.; GRIPP, T. E. H.; GOMES, P. S.; CALEIRO, M. C.; FULLER, R.; KAIRALLA, R. A.; CARVALHO, C. R. R.