ELLEN CAROLINE TOLEDO DO NASCIMENTO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina
40 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 40
- Acute Fibrinoid Organizing Pneumonia in Lung Transplant: The Most Feared Allograft Dysfunction(2016) COSTA, Andre Nathan; CARRARO, Rafael Medeiros; NASCIMENTO, Ellen Caroline Toledo; AFONSO JUNIOR, Jose Eduardo; CAMPOS, Silvia Vidal; CAMARGO, Priscila Cilene Leon Bueno de; TEIXEIRA, Ricardo Henrique de Oliveira Braga; SAMANO, Marcos Naoyuki; FERNANDES, Lucas Matos; ABDALLA, Luis Gustavo; DOLHNIKOFF, Marisa
- Eosinophilic pneumonia: remember topical drugs as possible etiology(2018) DIAS, Olivia Meira; NASCIMENTO, Ellen Caroline Toledo do; CHATE, Rodrigo Caruso; KAIRALLA, Ronaldo Adib; BALDI, Bruno Guedes
- Pulmonary involvement in Crohn's disease(2018) ATHAYDE, Rodolfo Augusto Bacelar de; COSTA, Felipe Marques da; NASCIMENTO, Ellen Caroline Toledo do; SALES, Roberta Karla Barbosa de; COSTA, Andre Nathan
- Lung ECM composition, its influence factors and transcriptomics in the lungs of severe COVID-19.(2023) COSTA, Natalia de Souza Xavier; RIBEIRO JUNIOR, Gabriel; NASCIMENTO, Ellen Toledo Do; BRITO, Jose Mara De; MONTEIRO, Jhonatas Sirino; SETUBAL, Joao Carlos; PINHO, Joao Renato Rebello; PEREIRA, Roberta Verciano; MONTEIRO, Renata Aparecida De Almeida; DUARTE NETO, Amaro Nunes; SALDIVA, Paulo Hilario Nascimento; SILVA, Luiz Fernando Ferraz Da; DOLHNIKOFF, Marisa; MAUAD, Thais
conferenceObject Association Of Sarcoidosis, Monoclonal Gammopathy Of Undetermined Significance And Cardiac Amyloidosis: A Case Report(2017) AMARAL, A. F.; OLIVEIRA, M. R.; ARIMURA, F. E.; NASCIMENTO, E. C. T.; BERNARDI, F. C.; FERNANDES, F.; CARVALHO, C. R. R.; KAIRALLA, R. A.; BALDI, B. G.conferenceObject Constrictive Bronchiolitis Mimicking Pulmonary Lymphangioleiomyomatosis(2016) TOLEDO, A. P.; ENDLICH, B. N.; ARIMURA, F. E.; FREITAS, C. S.; NASCIMENTO, E. C. T.; BERNARDI, F. D. C.; DOLHNIKOFF, M.; KAIRALLA, R. A.; BALDI, B. G.; CARVALHO, C. R.- Small airways morphological alterations associated with functional impairment in lymphangioleiomyomatosis(2024) MENDONCA, Ligia Pelosi; COSTA, Natalia de Souza Xavier; NASCIMENTO, Ellen Caroline Toledo do; OLIVEIRA, Martina Rodrigues de; CARVALHO, Carlos Roberto Ribeiro de; BALDI, Bruno Guedes; DOLHNIKOFF, MarisaBackgroundLymphangioleiomyomatosis (LAM) is a rare neoplastic and cystic pulmonary disease characterized by abnormal proliferation of the so-called LAM cells. Despite the functional obstructive pattern observed in most patients, few studies investigated the morphological changes in the small airways, most of them in patients with severe and advanced LAM undergoing lung transplantation. Understanding the morphological changes in the airways that may occur early in the disease can help us understand the pathophysiology of disease progression and understand the rationale for possible therapeutic approaches, such as the use of bronchodilators. Our study aimed to characterize the morphological alterations of the small airways in patients with LAM with different severities compared to controls, and their association with variables at the pulmonary function test and with LAM Histological Score (LHS).MethodsThirty-nine women with LAM who had undergone open lung biopsy or lung transplantation, and nine controls were evaluated. The histological severity of the disease was assessed as LHS, based on the percentage of tissue involvement by cysts and infiltration by LAM cells. The following morphometric parameters were obtained: airway thickness, airway closure index, collagen and airway smooth muscle content, airway epithelial TGF-beta expression, and infiltration of LAM cells and inflammatory cells within the small airway walls.ResultsThe age of patients with LAM was 39 +/- 8 years, with FEV1 and DLCO of 62 +/- 30% predicted and 62 +/- 32% predicted, respectively. Patients with LAM had increased small airway closure index, collagen and smooth muscle content, and epithelial TGF-beta expression compared with controls. Patients with LAM with the more severe LHS and with greater functional severity (FEV1 <= 30%) presented higher thicknesses of the airways. Bronchiolar inflammation was mild; infiltration of the small airway walls by LAM cells was rare. LHS was associated with an obstructive pattern, air trapping, and reduced DLCO, whereas small airway wall thickness was associated with FEV1, FVC, and collagen content.ConclusionLAM is associated with small airway remodelling and partial airway closure, with structural alterations observed at different airway compartments. Functional impairment in LAM is associated with airway remodelling and, most importantly, with histological severity (LHS).
conferenceObject Peribronchiolar Metaplasia Associated to Interstitial Lung Disease: A Case Report(2022) SANTOS, G. D.; BRIDI, G. D.; SAAVEDRA, N. L. M.; VASCONCELOS, A.; SILVA, N. F.; ALMEIDA, G. C.; NASCIMENTO, E. C. T.; ARIMURA, F. E.; AMARAL, A. F.; BALDI, B. G.; KAIRALLA, R. A.- Diffuse cystic lung disease as the primary tomographic manifestation of bronchiolitis: A case series(2020) OLIVEIRA, M. R. de; DIAS, O. M.; AMARAL, A. F.; NASCIMENTO, E. C. T. do; WANDERLEY, M.; CARVALHO, C. R. R.; BALDI, B. G.
conferenceObject Primary Lung Fibrous Histiocytoma Presenting as Diffuse Pulmonary Cystic Disease(2020) MAIA, A. P.; MARTIN, S. R. San; BRIDI, G. P.; BEDER, T. N.; COLARES, P. F.; HOLZ, I. M.; SERRA, J. P.; NASCIMENTO, E. C. T.; LIMA, L. G. C. A.; AMARAL, A. F.; OLIVEIRA, M. R.; BALDI, B. G.; KAIRALLA, R. A.