Cold Atmospheric Helium Plasma in the Post-COVID-19 Era: A Promising Tool for the Disinfection of Silicone Endotracheal Prostheses

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Citações na Scopus
0
Tipo de produção
article
Data de publicação
2024
DOI
Scopus
Web of Science
PubMed
Dimensions
Título da Revista
ISSN da Revista
Título do Volume
Editora
MDPI
Autores
SILVA, Diego Morais da
NASCIMENTO, Fellype Do
MILHAN, Noala Vicensoto Moreira
OLIVEIRA, Maria Alcioneia Carvalho de
LEGENDRE, Daniel
AOKI, Fabio Gava
KOSTOV, Konstantin Georgiev
KOGA-ITO, Cristiane Yumi
Citação
MICROORGANISMS, v.12, n.1, article ID 130, 14p, 2024
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Despite the excellent properties of silicone endotracheal prostheses, their main limitation is the formation of a polymicrobial biofilm on their surfaces. It can cause local inflammation, interfering with the local healing process and leading to further complications in the clinical scenario. The present study evaluated the inhibitory effect of cold atmospheric plasma (CAP) on multispecies biofilms grown on the silicone protheses' surfaces. In addition to silicone characterization before and after CAP exposure, CAP cytotoxicity on immortalized human bronchial epithelium cell line (BEAS-2B) was evaluated. The aging time test reported that CAP could temporarily change the silicone surface wetting characteristics from hydrophilic (80.5 degrees) to highly hydrophilic (<5 degrees). ATR-FTIR showed no significant alterations in the silicone surficial chemical composition after CAP exposure for 5 min. A significant log reduction in viable cells in monospecies biofilms (log CFU/mL) of C. albicans, S. aureus, and P. aeruginosa (0.636, 0.738, and 1.445, respectively) was detected after CAP exposure. Multispecies biofilms exposed to CAP showed significant viability reduction for C. albicans and S. aureus (1.385 and 0.831, respectively). The protocol was not cytotoxic to BEAS-2B. CAP can be a simple and effective method to delay multispecies biofilm formation inside the endotracheal prosthesis.
Palavras-chave
multispecies biofilm, non-thermal plasma, endotracheal tubes, silicone prosthesis, COVID-19
URI
https://observatorio.fm.usp.br/handle/OPI/59285
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Coleções
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - COVID-19