Livros e Capítulos de Livros - FM/MDR
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A coleção de Livros e Capítulos de Livros reúne capítulos e resumos de obras produzidas por autores do complexo Hospital das Clínicas - Faculdade de Medicina da Universidade de São Paulo.
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bookPart Epidemiologia do câncer de pulmão: visão do oncologista: ocidente versus oriente(2022) CASTRO JUNIOR, Gilberto de; MACHADO, Maria Cecília Mathias; YEN, Cheng TzubookPart Prefácio(2023) CERRI, Giovanni GuidobookPart Prefácio(2023) CERRI, Giovanni Guido- Par-4 in apoptosis during human salivary gland development and tumorigenesis(2022) COUTINHO-CAMILLO, C. M.; GOMES, A. N. de Mello; PAULA, F. D.; NAGAI, M. A.; LOURENCO, S. V.Human salivary glands (SGs) are complex structures comprising a system of ducts and acini formed in gradual stages termed the prebud, initial bud, pseudoglandular, canalicular, and terminal bud. This process involves growth, proliferation, differentiation, migration, and cell death. Studies in human specimens and in vitro models have demonstrated that apoptosis seems to be important not only during the early developmental stages of the salivary glands, but also contributes to the tumorigenic process and impacts the patient's treatment. Therefore, the screening of proteins associated with apoptosis might contribute to the development of different strategies focusing on cancer diagnosis, prognosis, and target therapies. The prostate apoptosis response-4 (PAR-4) is a 38 kDa protein encoded by the PAWR gene (PKC apoptosis WT1 regulator) that is ubiquitously expressed in different tissues and plays a role in both the intrinsic and extrinsic apoptotic pathways. This chapter explores the current knowledge on the expression of Par-4 during human salivary gland development and in the most frequent salivary gland tumors (benign: pleomorphic adenoma and malignant: adenoid cystic carcinoma and mucoepidermoid carcinoma). In addition to the application of Par-4 as a tumor prognostic marker, the use of targeted therapies against Par-4 is increasingly considered as an important strategy for cancer treatment. © Springer Nature Switzerland AG 2021. All rights reserved.
- PET-CT of ovarian cancer(2011) BUCHPIGUEL, C. A.PET-CT has no current role in the initial diagnosis of ovarian cancer. While imaging studies are not the basis of staging, imaging studies are often performed preoperatively (usually CT or MRI of the abdomen and pelvis) on patients suspected of advanced disease. A major advantage of PET-CT is the registered and aligned nature of the detailed anatomic images generated by the multidetector CT technology with the images of tissue metabolism possible by the PET technology. This allows for staging based on anatomic classification such as determining local extension of tumor into adjacent structures. Moreover, subtle metabolic abnormalities on FDG PET can be missed or misinterpreted as physiologic concentration of tracer, and the coregistration of the PET images with CT helps to further identify the lesion based on morphologic criteria. © 2011 Springer Science+Business Media, LLC.
- fMRI and fNIRS Methods for Social Brain Studies: Hyperscanning Possibilities(2022) BAZáN, P. R.; AMARO, E. Jr.Recently, the “social brain” (i.e., how the brain works in social context and the mechanisms for our social behavior) has gained focus in neuroscience literature - largely due to the fact that recently developed techniques allow studying different aspects of human social cognition and its brain correlates. In this context, hyperscanning techniques (Montague et al., Neuroimage 16(4):1159-1164, 2002) open the horizon for human interaction studies, allowing for the evaluation of interbrain connectivity. These techniques represent methods for simultaneously recording signals from different brains when subjects are interacting. In this chapter, we will explore the potentials of functional magnetic resonance imaging (fMRI) and functional near-infrared spectroscopy (fNIRS), which are techniques based on blood-oxygen-level-dependent (BOLD) signal. We will start with a brief explanation of the BOLD response basic principles and the mechanisms involved in fMRI and fNIRS measurements related to brain function. We will then discuss the foundation of the social brain, based on the first studies, with one subject per data acquisition, to allow for understanding the new possibilities that hyperscanning techniques offer. Finally, we will focus on the scientific literature reporting fMRI and fNIRS hyperscanning contribution to understand the social brain. © The Editor(s) (if applicable) and The Author(s) 2023.
bookPart Bases moleculares da carcinogênese gástrica(2017) RIBEIRO JUNIOR, Ulysses; SAFATLE-RIBEIRO, Adriana Vaz; PASINI, Fátima SolangebookPart Terapia molecular em tumores gastrintestinais(2017) SCARANTI, Mariana; BRAGHIROLI, Maria Ignez; HOFF, Paulo Marcelo GehmbookPart Biobancos(2017) UNO, Miyuki; CHAMMAS, RogerbookPart Bases da biologia molecular(2017) MAZZOTTI, Tatiane Katsue Furuya; LEAL, Mariana Ferreira; CIRILO, Priscila Daniele Ramos; CHAMMAS, RogerbookPart Radiofarmácia(2017) MARQUES, Fabio Luiz Navarro; FARIA, Daniele de Paula; FERREIRA, Roberta MorgadobookPart Proteção radiológica e dosimetria(2017) COUTINHO, Artur Martins Novaes; GUIMARãES, Maria Inês Calil CurybookPart Princípios básicos de física das radiações(2017) GUIMARãES, Maria Inês Calil Cury; LIMA, Marcos SantosbookPart Prefácio(2014) CERRI, Giovanni GuidobookPart Terapia de metástases ósseas(2017) COURA FILHO, George Barberio; SAPIENZA, Marcelo TatitbookPart Prefácio da 1ª edição(2017) CERRI, Giovanni GuidobookPart Apresentação da 1ª edição(2017) HIRONAKA, Fausto HarukibookPart Apresentação da 2ª edição(2017) HIRONAKA, Fausto HarukibookPart Prefácio da 2ª edição(2017) CERRI, Giovanni Guido