Nonstructural Genetic Cardiac Disease as the Most Common Cause of Sudden Cardiac Death in the Young Athlete: Is This True?

Nenhuma Miniatura disponível
Citações na Scopus
0
Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
Dimensions
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGERNATURE
Autores
STEIN, Ricardo
FERRARI, Filipe
BEUREN, Thais M. A.
SILVEIRA, Anderson D. D. da
Citação
CURRENT TREATMENT OPTIONS IN CARDIOVASCULAR MEDICINE, v.25, n.10, p.525-542, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Purpose of reviewThis review is aimed at summarizing and discussing the primary causes of sudden cardiac death (SCD) in young athletes.Recent findingsSCD in young athletes is a dramatic event, with an incidence rate that can reach 13 deaths per 100,000 athletes. Occasionally, exercise can trigger SCD, and unfortunately, this event may be the first manifestation of an underlying and silent cardiac condition. In the USA, hypertrophic cardiomyopathy is reported as the leading cause of SCD among young athletes, whereas arrhythmogenic right ventricular cardiomyopathy has been reported as the main cause in the Veneto region of Italy. However, emerging evidence has demonstrated that in many cases, athletes who experience sudden death have a seemingly normal cardiac structure, suggesting the possibility of sudden arrhythmic death syndrome. In recent decades, it has been possible to determine the causes of many SCDs that occur in the presence of nonstructural cardiac diseases. It is worth noting that routinely used cardiovascular screening methods, such as electrocardiogram and echocardiogram, may fail to detect nonstructural genetic cardiac diseases. In turn, in some circumstances, genetic testing may play a role in identifying individuals at risk of SCD due to these conditions.Understanding the underlying causes of SCD in young athletes is noteworthy for developing effective prevention and screening strategies. A multidisciplinary approach involving cardiologists, clinical sports physicians, pathologists, and geneticists collaborating represents an opportunity to enhance and optimize patient care and can play a crucial role in the prevention of SCD among young athletes.
Palavras-chave
Exercise, Athlete, Sudden cardiac death, Cardiomyopathies, Channelopathies
URI
https://observatorio.fm.usp.br/handle/OPI/59289
Referências
  1. Abbas M, 2022, ARRHYTH ELECTROPHYSI, V11, DOI 10.15420/aer.2022.09
  2. Abouk R, 2018, INT J DRUG POLICY, V53, P1, DOI 10.1016/j.drugpo.2017.11.022
  3. Ackerman MJ, 2001, AM J FOREN MED PATH, V22, P105, DOI 10.1097/00000433-200106000-00001
  4. Amin AS, 2009, CIRC-ARRHYTHMIA ELEC, V2, P531, DOI 10.1161/CIRCEP.109.862441
  5. [Anonymous], DEV PARTNERSHIP ENDO
  6. Aziz Peter F, 2015, JACC Clin Electrophysiol, V1, P62
  7. Barretta F, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21186682
  8. Basavarajaiah S, 2008, J AM COLL CARDIOL, V51, P1033, DOI 10.1016/j.jacc.2007.10.055
  9. Bohm P, 2023, EUROPACE, V25, P627, DOI 10.1093/europace/euac172
  10. Bohm P, 2016, EUR J PREV CARDIOL, V23, P649, DOI 10.1177/2047487315594087
  11. Brugada Ramon, 2014, Methodist Debakey Cardiovasc J, V10, P25
  12. Chambers KD, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.116.005445
  13. Chami T, 2019, MAYO CLIN PROC, V94, P1647, DOI 10.1016/j.mayocp.2019.05.008
  14. Christina G, 2020, EUR HEART J-CASE REP, V4, DOI 10.1093/ehjcr/ytaa299
  15. Chung EH, 2015, J ELECTROCARDIOL, V48, P539, DOI 10.1016/j.jelectrocard.2015.05.001
  16. Corrado D, 2003, J AM COLL CARDIOL, V42, P1959, DOI 10.1016/j.jacc.2003.03.002
  17. D'Ascenzi F, 2022, TRENDS CARDIOVAS MED, V32, P299, DOI 10.1016/j.tcm.2021.06.001
  18. Daw JM, 2022, HEART RHYTHM O2, V3, P233, DOI 10.1016/j.hroo.2022.01.011
  19. de Noronha SV, 2009, HEART, V95, P1409, DOI 10.1136/hrt.2009.168369
  20. de Noronha SV, 2014, EUROPACE, V16, P899, DOI 10.1093/europace/eut329
  21. Drezner JA, 2017, BRIT J SPORT MED, V51, P704, DOI 10.1136/bjsports-2016-097331
  22. Eckart RE, 2004, ANN INTERN MED, V141, P829, DOI 10.7326/0003-4819-141-11-200412070-00005
  23. Emery MS, 2018, JACC-HEART FAIL, V6, P30, DOI 10.1016/j.jchf.2017.07.014
  24. Farwell D, 2007, CAN J CARDIOL, V23, p16A, DOI 10.1016/S0828-282X(07)71001-2
  25. Finocchiaro G, 2017, J AM COLL CARDIOL, V69, P1644, DOI 10.1016/j.jacc.2017.01.023
  26. Finocchiaro G, 2016, J AM COLL CARDIOL, V67, P2108, DOI 10.1016/j.jacc.2016.02.062
  27. Fischbach P, 2017, CARDIOL YOUNG, V27, pS75, DOI 10.1017/S1047951116002274
  28. Giudicessi JR, 2019, HEART RHYTHM, V16, P1232, DOI 10.1016/j.hrthm.2019.02.012
  29. Gomez AT, 2016, SPORTS HEALTH, V8, P627, DOI 10.1177/1941738116660294
  30. Han JN, 2023, J CARDIOVASC DEV DIS, V10, DOI 10.3390/jcdd10020068
  31. Harmon KG, 2015, CIRCULATION, V132, P10, DOI 10.1161/CIRCULATIONAHA.115.015431
  32. Harmon KG, 2014, HEART, V100, P1185, DOI 10.1136/heartjnl-2014-093872.rep
  33. Harmon KG, 2014, CIRC-ARRHYTHMIA ELEC, V7, P198, DOI 10.1161/CIRCEP.113.001376
  34. Heidbuchel H, 2021, EUROPACE, V23, P147, DOI 10.1093/europace/euaa106
  35. Holst AG, 2010, HEART RHYTHM, V7, P1365, DOI 10.1016/j.hrthm.2010.05.021
  36. Isbister JC, 2021, INT J CARDIOL, V324, P96, DOI 10.1016/j.ijcard.2020.09.031
  37. Johnson JN, 2012, JAMA-J AM MED ASSOC, V308, P764, DOI 10.1001/jama.2012.9334
  38. Kawata H, 2016, CIRC J, V80, P1907, DOI 10.1253/circj.CJ-16-0250
  39. Krahn Andrew D, 2016, JACC Clin Electrophysiol, V2, P263, DOI 10.1016/j.jacep.2016.04.002
  40. Kramer CC, 2020, CLIN CASE REP, V8, P1409, DOI 10.1002/ccr3.2854
  41. Landry CH, 2017, NEW ENGL J MED, V377, P1943, DOI 10.1056/NEJMoa1615710
  42. Lu JT, 2010, CURR OPIN CARDIOL, V25, P216, DOI 10.1097/HCO.0b013e32833846b3
  43. Makimoto H, 2010, J AM COLL CARDIOL, V56, P1576, DOI 10.1016/j.jacc.2010.06.033
  44. Malhotra A, 2018, NEW ENGL J MED, V379, P524, DOI 10.1056/NEJMoa1714719
  45. Manolis AS, 2016, PACE, V39, P748, DOI 10.1111/pace.12879
  46. Marijon E, 2011, CIRCULATION, V124, P672, DOI 10.1161/CIRCULATIONAHA.110.008979
  47. Maron BJ, 2007, CARDIOL CLIN, V25, P399, DOI 10.1016/j.ccl.2007.07.006
  48. Maron BJ, 2014, J AM COLL CARDIOL, V63, P1636, DOI 10.1016/j.jacc.2014.01.041
  49. Maron BJ, 2009, CIRCULATION, V119, P1085, DOI 10.1161/CIRCULATIONAHA.108.804617
  50. Maron BJ, 2005, HEART, V91, P1380, DOI 10.1136/hrt.2005.060962
  51. Mascia G, 2017, INT J SPORTS MED, V38, P573, DOI 10.1055/s-0043-107240
  52. Masrur S, 2015, CLIN CARDIOL, V38, P323, DOI 10.1002/clc.22386
  53. Mazzanti A, 2022, JAMA CARDIOL, V7, P504, DOI 10.1001/jamacardio.2022.0219
  54. Morentin B, 2019, DRUG ALCOHOL DEPEN, V201, P23, DOI 10.1016/j.drugalcdep.2019.03.021
  55. Ostby Stuart A, 2016, JACC Clin Electrophysiol, V2, P253, DOI 10.1016/j.jacep.2016.01.020
  56. Pappone C, 2014, CIRCULATION, V130, P811, DOI 10.1161/CIRCULATIONAHA.114.011154
  57. Suárez-Mier MP, 2013, FORENSIC SCI INT, V226, P188, DOI 10.1016/j.forsciint.2013.01.016
  58. Peterson DF, 2021, BRIT J SPORT MED, V55, P1196, DOI 10.1136/bjsports-2020-102666
  59. Priori SG, 2002, CIRCULATION, V106, P69, DOI 10.1161/01.CIR.0000020013.73106.D8
  60. Rajan D, 2022, EUR HEART J, V43, P1198, DOI 10.1093/eurheartj/ehab833
  61. Ritt LE, 2022, EUR J PREV CARDIOL, V29, P1630, DOI 10.1093/eurjpc/zwac109
  62. Roston TM, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0205925
  63. Roston TM, 2018, HEART RHYTHM, V15, P1791, DOI 10.1016/j.hrthm.2018.06.046
  64. Roston TM, 2015, CIRC-ARRHYTHMIA ELEC, V8, P633, DOI 10.1161/CIRCEP.114.002217
  65. Scheiper-Welling S, 2022, INT J LEGAL MED, V136, P475, DOI 10.1007/s00414-021-02764-z
  66. SHARMA AD, 1987, J AM COLL CARDIOL, V10, P373, DOI 10.1016/S0735-1097(87)80021-9
  67. Stepien-Wojno M, 2020, DIAGNOSTICS, V10, DOI 10.3390/diagnostics10070435
  68. Suáez-Mier MP, 2002, REV ESP CARDIOL, V55, P347
  69. Suzuki-Yamanaka M, 2022, J SCI MED SPORT, V25, P705, DOI 10.1016/j.jsams.2022.06.011
  70. Tester DJ, 2012, MAYO CLIN PROC, V87, P524, DOI 10.1016/j.mayocp.2012.02.017
  71. Thiene G, 2019, J AM COLL CARDIOL, V73, P3031, DOI 10.1016/j.jacc.2019.03.497
  72. Tobert KE, 2021, J AM COLL CARDIOL, V78, P594, DOI 10.1016/j.jacc.2021.04.026
  73. Torkamani A, 2016, JAMA-J AM MED ASSOC, V316, P1492, DOI 10.1001/jama.2016.11445
  74. van der Werf C, 2012, CIRC-ARRHYTHMIA ELEC, V5, P748, DOI 10.1161/CIRCEP.112.970517
  75. Viskin S, 2020, CIRCULATION, V142, P2416, DOI 10.1161/CIRCULATIONAHA.120.051434
  76. Wasfy Meagan M, 2016, Methodist Debakey Cardiovasc J, V12, P76, DOI 10.14797/mdcj-12-2-76
  77. Weizman O, 2023, J AM COLL CARDIOL, V81, P1021, DOI 10.1016/j.jacc.2023.01.015
  78. Wever EFD, 2004, J AM COLL CARDIOL, V43, P1137, DOI 10.1016/j.jacc.2003.10.053
  79. Wisten A, 2019, RESUSCITATION, V144, P99, DOI 10.1016/j.resuscitation.2019.09.022

Coleções
Artigos e Materiais de Revistas Científicas - HC/InCor