Association between carotid intima-media thickness and cognitive decline differs by race

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Citações na Scopus
0
Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY
Autores
BERTOLA, Laiss
BITTENCOURT, Marcio S.
BARRETO, Sandhi Maria
GIATTI, Luana
CARAMELLI, Paulo
Citação
ALZHEIMERS & DEMENTIA, v.19, n.8, p.3528-3536, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
IntroductionCommon carotid intima-media thickness (cIMT) is a marker of subclinical atherosclerosis and is associated with cognitive decline. Although carotid atherosclerosis is more frequent in White than in Black participants, little is known whether race modifies the association between cIMT and cognitive decline. MethodsIn this longitudinal analysis of the ELSA-Brasil, we assessed cIMT using ultrasound and cognitive performance using different domain tests. We used linear mixed models, interaction analysis, and race stratified analyses. ResultsBaseline high IMT values were associated with memory (p < 0.001), verbal fluency (p < 0.001), TMT-B (p < 0.001)), and global cognitive decline (p < 0.001). Race was an effect modifier in the association between IMT and global cognitive decline (0.043), with stronger association in White (p < 0.001) than in Black (p = 0.009) participants. DiscussionBaseline IMT was associated with global and domain-specific cognitive decline and race modified this relationship, with stronger associations in White participants. HighlightsCarotid intima-media thickness (cIMT) was associated with cognitive decline.cIMT and cognitive decline association was stronger in White than in Black participants.We used inverse probability weighting to address attrition bias.
Palavras-chave
carotid intima-media thickness, cognitive decline, ELSA-Brasil, epidemiology, race
URI
https://observatorio.fm.usp.br/handle/OPI/57325
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/13
Artigos e Materiais de Revistas Científicas - LIM/20
Artigos e Materiais de Revistas Científicas - LIM/22
Artigos e Materiais de Revistas Científicas - LIM/51
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