LIM/31 - Laboratório de Genética e Hematologia Molecular

URI Permanente desta comunidade

https://observatorio.fm.usp.br/handle/OPI/3718
O Laboratório de Genética e Hematologia Molecular é ligado ao Departamento de Clínica Médica da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: Genética e hematologia molecular; terapia celular e gênica; onco-hematologia; hemostasia; metabolismo lipídico.

Site oficial: http://limhc.fm.usp.br/portal/lim31-laboratorio-de-genetica-e-hematologia-molecular/

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Data-driven, cross-disciplinary collaboration: lessons learned at the largest academic health center in Latin America during the COVID-19 pandemic
(2024) RITTO, Ana Paula; ARAUJO, Adriana Ladeira de; CARVALHO, Carlos Roberto Ribeiro de; SOUZA, Heraldo Possolo De; FAVARETTO, Patricia Manga e Silva; SABOYA, Vivian Renata Boldrim; GARCIA, Michelle Louvaes; KULIKOWSKI, Leslie Domenici; KALLAS, Esper Georges; PEREIRA, Antonio Jose Rodrigues; COBELLO JUNIOR, Vilson; SILVA, Katia Regina; ABDALLA, Eidi Raquel Franco; SEGURADO, Aluisio Augusto Cotrim; SABINO, Ester Cerdeira; RIBEIRO JUNIOR, Ulysses; FRANCISCO, Rossana Pulcineli Vieira; MIETHKE-MORAIS, Anna; LEVIN, Anna Sara Shafferman; SAWAMURA, Marcio Valente Yamada; FERREIRA, Juliana Carvalho; SILVA, Clovis Artur; MAUAD, Thais; GOUVEIA, Nelson da Cruz; LETAIF, Leila Suemi Harima; BEGO, Marco Antonio; BATTISTELLA, Linamara Rizzo; DUARTE, Alberto Jose da Silva; SEELAENDER, Marilia Cerqueira Leite; MARCHINI, Julio; FORLENZA, Orestes Vicente; ROCHA, Vanderson Geraldo; MENDES-CORREA, Maria Cassia; COSTA, Silvia Figueiredo; CERRI, Giovanni Guido; BONFA, Eloisa Silva Dutra de Oliveira; CHAMMAS, Roger; BARROS FILHO, Tarcisio Eloy Pessoa de; BUSATTO FILHO, Geraldo
Introduction The COVID-19 pandemic has prompted global research efforts to reduce infection impact, highlighting the potential of cross-disciplinary collaboration to enhance research quality and efficiency.Methods At the FMUSP-HC academic health system, we implemented innovative flow management routines for collecting, organizing and analyzing demographic data, COVID-related data and biological materials from over 4,500 patients with confirmed SARS-CoV-2 infection hospitalized from 2020 to 2022. This strategy was mainly planned in three areas: organizing a database with data from the hospitalizations; setting-up a multidisciplinary taskforce to conduct follow-up assessments after discharge; and organizing a biobank. Additionally, a COVID-19 curated collection was created within the institutional digital library of academic papers to map the research output.Results Over the course of the experience, the possible benefits and challenges of this type of research support approach were identified and discussed, leading to a set of recommended strategies to enhance collaboration within the research institution. Demographic and clinical data from COVID-19 hospitalizations were compiled in a database including adults and a minority of children and adolescents with laboratory confirmed COVID-19, covering 2020-2022, with approximately 350 fields per patient. To date, this database has been used in 16 published studies. Additionally, we assessed 700 adults 6 to 11 months after hospitalization through comprehensive, multidisciplinary in-person evaluations; this database, comprising around 2000 fields per subject, was used in 15 publications. Furthermore, thousands of blood samples collected during the acute phase and follow-up assessments remain stored for future investigations. To date, more than 3,700 aliquots have been used in ongoing research investigating various aspects of COVID-19. Lastly, the mapping of the overall research output revealed that between 2020 and 2022 our academic system produced 1,394 scientific articles on COVID-19.Discussion Research is a crucial component of an effective epidemic response, and the preparation process should include a well-defined plan for organizing and sharing resources. The initiatives described in the present paper were successful in our aim to foster large-scale research in our institution. Although a single model may not be appropriate for all contexts, cross-disciplinary collaboration and open data sharing should make health research systems more efficient to generate the best evidence.
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EDUCATIONAL AUDIT PROCESS FOR HEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT) REPORTS
(2023) GERALDO, Bruna; SIMIONE, Anderson; SEBER, Adriana; MARIANO, Livia; VERGUEIRO, Carmen
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BMT BRAZILIAN MAP: COMPARISON OF BMT MAP WITH EBMT ACTIVITY SURVEY AND ACTIVITY REPORT CIBMTR
(2023) SIMIONE, Anderson Joao; SEBER, Adriana; MARIANO, Livia Caroline Barbosa; GERALDO, Bruna Leticia da Silva Santos; SANTOS, Rosana Machado dos; TALARICO, Wiliam Odair; VERGUEIRO, Carmen Silvia Vieitas
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Isatuximab plus carfilzomib and dexamethasone versus carfilzomib and dexamethasone in patients with relapsed multiple myeloma (IKEMA): final overall survival analysis
(2023) YONG, Kwee; MARTIN, Thomas; DIMOPOULOS, Meletios; MIKHAEL, Joseph; CAPRA, Marcelo; FACON, Thierry; HAJEK, Roman; SPICKA, Ivan; BAKER, Ross; KIM, Kihyun; MARTINEZ, Gracia; MIN, Chang-Ki; POUR, Ludek; LELEU, Xavier; ORIOL, Albert; KOH, Youngil; SUZUKI, Kenshi; CASCA, France; MACE, Sandrine; RISSE, Marie-Laure; MOREAU, Philippe
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Genetic variation in HLA genes: impact on transplant compatibility in a Brazilian admixed population
(2023) ANDRADE, Heloisa S.; SILVA, Marcio; NUNES, Kelly; PASSOS, Carlos Henrique; SENA, Alexandre C.; CASTELLI, Erick C.; DINARDO, Carla; SABINO, Ester C.; TEIXEIRA, Carolina M.; TELES, Dahra; AMORIM, Luiz; CUSTER, Brian; KELLY, Shannon; PORTO, Luis Cristovao; MEYER, Diogo
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Safety and Efficacy of an Academic Anti-CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy for Non-Hodgkin Lymphoma and Acute Lymphoblastic Leukemia Developed in Brazil: Increasing Access in a Public Health System
(2023) PIRES, Bruno Garcia; CLE, Diego Villa; DONADEL, Camila Derminio; GAVA, Flavia Mesquita; PALMA, Leonardo Carvalho; SANTIS, Gil Cunha De; ROCHA, Vanderson; CALADO, Rodrigo do Tocantins; COVAS, Dimas Tadeu
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HLA ALLELE AND HAPLOTYPE FREQUENCIES IN SICKLE CELL DISEASE AND THALASSEMIA PATIENTS: A JOINT STUDY ON BEHALF OF EUROCORD AND SFGM-TC
(2023) SCIGLIUOLO, Graziana Maria; CAPPELLI, Barbara; BOUKOUACI, Wahid; ROBIN, Marie; NGUYEN, Stephanie; RAUS, Nicole; DHEDIN, Nathalie; LATOUR, Regis Peffault de; DEVALCK, Christine; DALLE, Jean-Hugues; MAIRE, Pierre Quartier Dit; HERMINE, Olivier; CHARDIN, Marie Ouachee; POIRE, Xavier; BRICHARD, Benedicte; PAILLARD, Catherine; BEGUIN, Yves; PLANTAZ, Dominique; BRUNO, Benedicte; YAKOUB-AGHA, Ibrahim; BOURHIS, Jean-Henri; VOLT, Fernanda; FRANCO, Monica Rivera; RAFII, Hanadi; KENZEY, Chantal; WU, Ching-Lien; BOUASSIDA, Jihene; ROCHA, Vanderson; RUGGERI, Annalisa; TAMOUZA, Ryad; GLUCKMAN, Eliane
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First report of PhALLCON: A phase 3 study comparing ponatinib (pon) vs imatinib (im) in newly diagnosed patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph plus ALL).
(2023) JABBOUR, Elias; KANTARJIAN, Hagop M.; ALDOSS, Ibrahim; MONTESINOS, Pau; LEONARD, Jessica Taft; GOMEZ-ALMAGUER, David; BAER, Maria R.; GAMBACORTI-PASSERINI, Carlo; MCCLOSKEY, James; MINAMI, Yosuke; PAPAYANNIDIS, Cristina; ROCHA, Vanderson Geraldo; ROUSSELOT, Philippe; VACHHANI, Pankit; WANG, Eunice S.; WANG, Bingxia; HENNESSY, Meliessa; VOROG, Alexander; PATEL, Niti; RIBERA, Josep-Maria
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REFINED ANALYSIS AT THE PEPTIDE-BINDING GROOVE LEVEL OF HLA AND GRAFT-VERSUS-HOST DISEASE ASSOCIATION IN PATIENTS WITH ACUTE LEUKEMIA WHO UNDERWENT UMBILICAL CORD BLOOD TRANSPLANTATION
(2023) BOUKOUACI, Wahid; FRANCO, Monica M. Rivera; VOLT, Fernanda; WU, Ching-Lien; RAFII, Hanadi; CAPPELLI, Barbara; SCIGLIUOLO, Graziana M.; KENZEY, Chantal; ROCHA, Vanderson; RUGGERI, Annalisa; GLUCKMAN, Eliane; TAMOUZA, Ryad
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High-dose chemotherapy with autologous stem cell transplant (HDCT) for patients (pts) with advanced germ-cell tumors (aGCT): Real-world evidence from a tertiary cancer center in Brazil.
(2023) POLHO, Gabriel Berlingieri; CUNHA, Mateus Trinconi; XAVIER, Erick Menezes; SILVA, Jamile Almeida; HIDALGO FILHO, Cassio Murilo Trovo; CRUSOE, Nathalia de Souza Del Rey; ATANAZIO, Marcelo Junqueira; HORITA, Vivian; FREITAS, Guilherme Fialho de; MUNIZ, David Queiroz Borges; ROCHA, Vanderson Geraldo; MOTA, Jose Mauricio