LIM/03 - Laboratório de Medicina Laboratorial

URI Permanente desta comunidade

https://observatorio.fm.usp.br/handle/OPI/3606
O Laboratório de Medicina Laboratorial é ligado ao Departamento de Patologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: epidemiologia; morfometria; defesa respiratória; poluição em plantas; patologia pulmonar e mutagênese ambiental.

Site oficial: http://limhc.fm.usp.br/portal/lim03-laboratorio-de-medicina-laboratorial/

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Data-driven, cross-disciplinary collaboration: lessons learned at the largest academic health center in Latin America during the COVID-19 pandemic
(2024) RITTO, Ana Paula; ARAUJO, Adriana Ladeira de; CARVALHO, Carlos Roberto Ribeiro de; SOUZA, Heraldo Possolo De; FAVARETTO, Patricia Manga e Silva; SABOYA, Vivian Renata Boldrim; GARCIA, Michelle Louvaes; KULIKOWSKI, Leslie Domenici; KALLAS, Esper Georges; PEREIRA, Antonio Jose Rodrigues; COBELLO JUNIOR, Vilson; SILVA, Katia Regina; ABDALLA, Eidi Raquel Franco; SEGURADO, Aluisio Augusto Cotrim; SABINO, Ester Cerdeira; RIBEIRO JUNIOR, Ulysses; FRANCISCO, Rossana Pulcineli Vieira; MIETHKE-MORAIS, Anna; LEVIN, Anna Sara Shafferman; SAWAMURA, Marcio Valente Yamada; FERREIRA, Juliana Carvalho; SILVA, Clovis Artur; MAUAD, Thais; GOUVEIA, Nelson da Cruz; LETAIF, Leila Suemi Harima; BEGO, Marco Antonio; BATTISTELLA, Linamara Rizzo; DUARTE, Alberto Jose da Silva; SEELAENDER, Marilia Cerqueira Leite; MARCHINI, Julio; FORLENZA, Orestes Vicente; ROCHA, Vanderson Geraldo; MENDES-CORREA, Maria Cassia; COSTA, Silvia Figueiredo; CERRI, Giovanni Guido; BONFA, Eloisa Silva Dutra de Oliveira; CHAMMAS, Roger; BARROS FILHO, Tarcisio Eloy Pessoa de; BUSATTO FILHO, Geraldo
Introduction The COVID-19 pandemic has prompted global research efforts to reduce infection impact, highlighting the potential of cross-disciplinary collaboration to enhance research quality and efficiency.Methods At the FMUSP-HC academic health system, we implemented innovative flow management routines for collecting, organizing and analyzing demographic data, COVID-related data and biological materials from over 4,500 patients with confirmed SARS-CoV-2 infection hospitalized from 2020 to 2022. This strategy was mainly planned in three areas: organizing a database with data from the hospitalizations; setting-up a multidisciplinary taskforce to conduct follow-up assessments after discharge; and organizing a biobank. Additionally, a COVID-19 curated collection was created within the institutional digital library of academic papers to map the research output.Results Over the course of the experience, the possible benefits and challenges of this type of research support approach were identified and discussed, leading to a set of recommended strategies to enhance collaboration within the research institution. Demographic and clinical data from COVID-19 hospitalizations were compiled in a database including adults and a minority of children and adolescents with laboratory confirmed COVID-19, covering 2020-2022, with approximately 350 fields per patient. To date, this database has been used in 16 published studies. Additionally, we assessed 700 adults 6 to 11 months after hospitalization through comprehensive, multidisciplinary in-person evaluations; this database, comprising around 2000 fields per subject, was used in 15 publications. Furthermore, thousands of blood samples collected during the acute phase and follow-up assessments remain stored for future investigations. To date, more than 3,700 aliquots have been used in ongoing research investigating various aspects of COVID-19. Lastly, the mapping of the overall research output revealed that between 2020 and 2022 our academic system produced 1,394 scientific articles on COVID-19.Discussion Research is a crucial component of an effective epidemic response, and the preparation process should include a well-defined plan for organizing and sharing resources. The initiatives described in the present paper were successful in our aim to foster large-scale research in our institution. Although a single model may not be appropriate for all contexts, cross-disciplinary collaboration and open data sharing should make health research systems more efficient to generate the best evidence.
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Pineal region high grade neuroepithelial tumors with NTRK fusions belonging to the novel methylation class ""diffuse high grade glioma, IDH-wildtype, subtype E"" (HGG_E)-A distinct clinicopathological and molecular presentation
(2023) COSTA, F. D'Almeida; CASTRO, J. V. Alves de; KULIKOWSKI, L. Domenici; WOLFF, B.; GREGIANIN, L. J.; NETO, C. Scapulatempo; KOTIDIS, C.; DALAHMAH, O. Al; CANOLL, P.; BRUCE, J.; ALDAPE, K.; ABDULLAEV, Z.; NASRALLAH, M.; ZANAZZI, G.
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Capelozzi's necrosis is a novel histological biomarker for the diagnosis of chronic microaspiration in fibrosing interstitial lung diseases
(2023) FABRO, Alexandre Todorovic; BATAH, Sabrina Setembre; ZIMERMAM, Heloisa Acurcio; MARCO, Maria Julia Faci Do; MORAES, Mateus Magalhaes Lage; TELINI, Wagner Moneda; LEME, Adriana Paes; DOMINGUES, Romenia Ramos; CARVALHO, Robson Francisco; SCHNEPPER, Amanda Piveta; CETLIN, Andrea Antunes; WADA, Danilo Tadao; SANTOS, Marcel Koenigkam; NADAI, Tales Rubens; BADDINI-MARTINEZ, Jose Antonio; CAPELOZZI, Vera Luiza
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Lung ECM composition, its influence factors and transcriptomics in the lungs of severe COVID-19.
(2023) COSTA, Natalia de Souza Xavier; RIBEIRO JUNIOR, Gabriel; NASCIMENTO, Ellen Toledo Do; BRITO, Jose Mara De; MONTEIRO, Jhonatas Sirino; SETUBAL, Joao Carlos; PINHO, Joao Renato Rebello; PEREIRA, Roberta Verciano; MONTEIRO, Renata Aparecida De Almeida; DUARTE NETO, Amaro Nunes; SALDIVA, Paulo Hilario Nascimento; SILVA, Luiz Fernando Ferraz Da; DOLHNIKOFF, Marisa; MAUAD, Thais
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Rapid HIV progression in patients with increased prevalence of unstable HLA-C variants
(2023) RUGGIERO, Alessandra; STEFANI, Chiara; SANGALLI, Antonella; LOCATELLI, Elena; FEDERICO, Tania; MALERBA, Giovanni; ROMANELLI, Maria Grazia; ARGANARAZ, Gustavo Adolfo; SILVA, Bosco Christiano Maciel Da; SILVA, Alberto Jose Duarte Da; CASSEB, Jorge; ARGANARAZ, Enrique Roberto; ZIPETO, Donato
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Buccal cell whole exome sequencing improves the diagnostic yield in a Cornelia de Lange Syndrome Brazilian cohort
(2024) NUNES, Beatriz Carvalho; FAVILLA, Bianca Pereira; VILELLA, Thaina; PINHEIRO, Isabel; AOI, Haromi; SEYAMA, Rie; MATSUMOTO, Naomichi; BELLUCCO, Fernanda Teixeira; KIM, Chong; MELARAGNO, Maria Isabel
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Investigation of copy number variations as possible genetic modifiers in patients with the 22q11.2 deletion syndrome
(2023) NUNES, Beatriz Carvalho; ZAMARIOLLI, Malu; DANTAS, Anelisa Gollo; SOARES, Diogo Cordeiro Queiroz; KIM, Chong Ae; MELARAGNO, Maria Isabel
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A 43 years-old patient with Cornelia de Lange Syndrome with NIPBL gene mutation and a mild phenotype
(2024) VILELLA, Thaina; NUNES, Beatriz Carvalho; PINHEIRO, Isabel; AOI, Haromi; MATSUMOTO, Naomichi; KIM, Chong; MELARAGNO, Maria Isabel
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LONGITUDINAL ASSESSMENT OF HAND AND WRIST BONE DESTRUCTION BY ULTRASOUND, AND ITS ASSOCIATION WITH DISEASE ACTIVITY IN PRIMARY SJOGREN'S SYNDROME
(2023) FRANCO, A. Silva; MURAI, I.; YANG, T.; SALES, L. Peixoto; GUEDES, L.; PASOTO, S.; FIGUEIREDO, C.; PEREIRA, R. M.
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microRNAs associated with metastatic potential in salivary gland mucoepidermoid carcinoma
(2023) TREVIZANI, Maria Eduarda S.; OLIVEIRA, Katia K.; MARCHI, Fabio A.; BIZINELLI, Daniela; MARIANO, Fernanda V.; NAGANO, Cibele P.; COSTA, Felipe A.; PINTO, Clovis A.; KOWALSKI, Luiz P.; LOURENCO, Silvia V.; COUTINHO-CAMILLO, Claudia M.