LIM/65 - Laboratório de Investigação Médica em Bioengenharia
URI Permanente desta comunidade
O Laboratório de Investigação Médica em Bioengenharia é ligado ao Departamento de Cardiopneumologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).
Linhas de pesquisa: bioengenharia Cardiovascular; órgãos artificiais; medicina assistida por computação científica; circulação extracorpórea translacional.
Site oficial: http://limhc.fm.usp.br/portal/lim-65-laboratorio-de-investigacao-medica-em-bioengenharia/
Linhas de pesquisa: bioengenharia Cardiovascular; órgãos artificiais; medicina assistida por computação científica; circulação extracorpórea translacional.
Site oficial: http://limhc.fm.usp.br/portal/lim-65-laboratorio-de-investigacao-medica-em-bioengenharia/
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Coleções desta Comunidade
- LIM/65 - Laboratório de Investigação Médica em Bioengenharia
- LIM/65 - Laboratório de Investigação Médica em Bioengenharia
- LIM/65 - Laboratório de Investigação Médica em Bioengenharia
Submissões Recentes
Treatment with empagliflozin improves cardiac function in infarcted animals associated with increased baroreflex sensitivity
(2023) SILVA, B. Da; NASCIMENTO-CARVALHO, B.; SOUZA, L. I. De; SILVA, M. B. Da; MARQUES, J. R.; DOURADO, P. M. M.; CONSOLIM-COLOMBO, F.; IRIGOYEN, M. C. C.
Transseptal puncture using electroanatomical mapping: a safe and cost-effective technique
(2023) BRIGIDO, A. Dantas; RASSI, G. M.; RODRIGUES, L. V.; LOVISI, V. B.; PISANI, C. F.; CHOKR, M. O.; HARDY, C. A.; MELO, S. L.; GONCALVES, A. L. M.; MAYRINK, M. P.; KULCHETSCKI, R. M.; SCANAVACCA, M. I.
A Multi-objective Physiological Control for Continuous Flow Left Ventricular Assist Devices: Comparison of Estimator versus Sensor-based Feedback
(2023) SANTOS, Bruno; CESTARI, Idagene
Left Ventricular Assist Devices have been successfully used for the treatment of Congestive Heart failure in patients who are not eligible for heart transplantation. This paper describes the implementation and comparison of the performance of a pressure sensor-based feedback controller. The strategies were tested on a mock loop of the systemic circulation. The results show that the use of pressure sensors generated a more accurate response of the controller compared to the use of estimators.
Sympathetic Neural Overdrive, Endothelial Dysfunction and Aortic Stiffness in Coronavirus Disease 2019 Survivors: A Short-Term Study of Cardiovascular Sequelae
(2021) FARIA, Diego; TESTA, Laura; MOLL-BERNARDES, Renata; MONIZ, Camila; RODRIGUES, Erika; COSTA-NETO, Abel; SOUSA, Andrea; RODRIGUES, Amanda; OLIVEIRA, Patricia; ALVES, Maria Janieire; SANTOS, Gabriel; SALEMI, Vera; PIMENTA, Ruan; PAIXAO, Camila; SANTOS, Beatriz; RONDON, Maria U.; CRAIGHEAD, Daniel; ROSSMAN, Matthew; CONSOLIM-COLOMBO, Fernanda M.; IRIGOYEN, Maria C.; MARTINEZ-LEMUS, Luis A.
Changes in physical performance after Fontan operation: a follow-up study
(2023) TURQUETTO, A. L. R.; AMATO, L. P.; SOUZA, F. R.; AGOSTINHO, D. R.; LIGEIRO, M. G.; FILHO, A. C. Battaglia; ALVES, M. J. N. N.; OLIVEIRA, P. A.; DIOTTO, F. M.; RONDON, E.; CANEO, L. F.; JATENE, M. B.
Noncontrast Transcatheter Aortic Valve Implantation for Patients With Aortic Stenosis and Chronic Kidney Disease: Long-Term Follow-Up of The Pilot Study
(2023) FILIPPINI, Filippe; FREIRE, Antonio Fernando; NICZ, Pedro; BRATZ, Guilherme; SESSA, Bruno; RIBEIRO, Henrique; ACCORSI, Tarso; LIBERATO, Gabriela; NOMURA, Cesar Higa; CASSAR, Renata; VIEIRA, Marcelo; BIHAN, David Le; BARRETTO, Rodrigo; MATHIAS, Wilson; POMERANTZEFF, Pablo; TARASOUTCHI, Flavio; ABIZAID, Alexandre; BRITO JR., Fabio
Diagnostic Accuracy of ECG to Detect Left Ventricular Hypertrophy in Patients with Left Bundle Branch Block A Systematic Review and Meta-analysis
(2023) SOUZA, Isabela A. F. de; PADRAO, Eduardo M. H.; MARQUES, Isabela R.; MIYAWAKI, Isabele A.; LOYOLA JUNIOR, Jose Eduardo Riceto; MOREIRA, Vittoria Caporal S.; GOMES, Cintia; SILVA, Caroliny H. A.; OPRYSKO, Carson; NETO, Augusto Barreto do Amaral; CARDOSO, Rhanderson; SAMESIANA, Nelson; PASTORE, Carlos Alberto; TAVARES, Caio A. M.
Background: Electrocardiographic (ECG) criteria to detect left ventricular hypertrophy (LVH) in patients with left bundle branch block (LBBB) remain under debate. We conducted a systematic review and meta-analysis to evaluate the diagnostic accuracy of different ECG criteria for diagnosing LVH in patients with LBBB.Methods: We searched PubMed, Embase, Cochrane, and LILACS for articles evaluating the diagnostic accuracy of ECG criteria for LVH in patients with LBBB published between 1984 and 2023. Echocardiogram, magnetic resonance imaging, or autopsy were used as the reference standard for diagnosis of LVH. Risk of bias was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. The co-primary outcomes were sensitivity, specificity, the diagnostic odds ratio, and likelihood ratios, estimated using a bivariate generalized linear mixed model for each ECG criterion. The prespecified protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO).Results: We included 12 studies with a total of 1023 patients. We analyzed 10 criteria for LVH on ECG, including the Sokolow-Lyon criterion, the Cornell criterion, the RaVL (R wave in aVL) criterion, the Gubner-Ungerleider criterion, and the Dalfo criterion, among others. The Dalfo criterion was used for 487 patients and had the highest pooled sensitivity of 86% (95% confidence interval [CI] 57%-97%). All the other criteria had poor sensitivities. The Gubner-Ungerleider criterion and the RV5 or RV6 > 25 mm criterion had the highest specificities, with the former being used for 805 patients, obtaining a specificity of 99% (95% CI 80%-100%) and the latter being used for 355 patients, obtaining a specificity of 99% (95% CI 94%-100%). Conclusions: In patients with LBBB, the use of ECG criteria had poor performance for ruling out LVH, mostly due to low sensitivities. None of the criteria analyzed demonstrated a balanced tradeoff between sensitivity and specificity, suggesting that ECG should not be used routinely to screen for LVH.
Early identification of oesophageal lesions after atrial fibrillation ablation to prevent atrio-oesophageal fistula
(2023) SCANAVACCA, Mauricio; PISANI, Cristiano; RIVAROLA, Esteban W. R.
Feasibility of Transatrial Access for Epicardial Ablation Evaluation of 2 Different Techniques in Swine
(2023) CHOKR, Muhieddine O.; VANDONI, Pedro Mario Pinto; NETO, Jose Nilo de Carvalho; MOURA, Lucas G. de; SOUSA, Italo Bruno dos Santos; AIELLO, Vera D.; BRITO, Fabio Sandoli de; PISANI, Cristiano F.; HARDY, Carina A.; MELO, Sissy L. de
BACKGROUND The subxiphoid pericardial access is technically difficult and has a considerable rate of complications, thus transatrial access may be an alternative. OBJECTIVES This study sought to assess the feasibility and safety of this strategy regarding periprocedural period and after 1-week follow-up. METHODS The investigators performed epicardial mapping through transatrial puncture in 20 swine. Animals were divided into group A, in which aspiration of the sheath was performed to maintain negative pressure after the withdraw of the catheters, and group B, in which a device (Konar-MF VSD Occluder) was delivered to occlude the right atrial appendage perforation. Bleeding was investigated immediately and 1 week after. RESULTS Access was safe in 19 of 20 animals (95%) with small amount of bleeding (6.4 +/- 6 mL). In group A (n = 10), 1 animal presented hemopericardium right after the puncture. In the other 9, epicardial ablation was performed and 60.0 +/- 28.0 mL of blood was aspirated without events. After 1 week, fibrin-hemorrhagic pericarditis was identified in 3 animals. In group B (n = 10), reaching the epicardial surface was possible in all animals. An adequate position of the prosthesis was obtained in 90% (9 of 10). One death occurred in the immediate postoperative period, secondary to pneumothorax. After 1 week, postmortem analysis showed absence of pericardial bleeding and a normal-appearing pericardium in the 8 animals with adequate prosthesis position. CONCLUSIONS Transatrial access allows epicardial mapping and ablation. Sheath removal after negative pressure contributes to achieving acute bleeding control but does not prevent its occurrence. The use of the device prevents bleeding and hemorrhagic pericarditis.
Electrovectorcardiographic study of left ventricular aneurysm in ischemic heart disease
(2023) VARONI, Leonardo Paschoal Camacho; SAMESIMA, Nelson; FACIN, Mirella; PEREIRA FILHO, Horacio Gomes; MADALOSO, Bruna Affonso; MATHIAS JUNIOR, Wilson; PASTORE, Carlos Alberto
The aim was to characterize the electrovectorcardiographic pattern of ventricular aneurysms in ischemic cardiopathy by analyzing the cardiac ventricular repolarization. The medical records of 2,670 individuals were analyzed in this cross-sectional study. A test phase included 33 patients who underwent transthoracic echocardiogram with ultrasonic enhancing agent, electrocardiogram, and vectorcardiogram (aneurysm group - n = 22, and akinesia group - n = 11). In the validation phase, cardiac magnetic resonance imaging established the left ventricle segmental contractility in 16 patients who underwent electrocardiographic and vectorcardiographic tests (aneurysm group, n = 8, and akinesia group, n = 8). The variables studied were the presence of the T-wave plus-minus pattern and the T-wave loop anterior-posterior pattern in V2-V4. The diagnostic indices used were sensitivity, specificity, and predictive values, with their respective 95% confidence intervals. During the test and validation phases, the analysis of the presence of the T-wave plus-minus pattern identified the aneurysm group with a sensitivity of 91% vs. 87% and specificity of 91% vs. 87% (p < 0.0001 vs. p = 0.01), respectively. Meanwhile, the T-wave loop anterior-posterior pattern evidenced sensitivity of 95% vs. 77% and specificity of 91% vs. 87% (p < 0.0001 vs. p = 0.04), respectively. The electrovectorcardiographic parameters showed high accuracy for recognizing left ventricular aneurysms in ischemic heart disease.