Social and behavioral characteristics of male blood donors and their sexual partners: an analysis to define risk subsets

Imagem de Miniatura
Arquivos
art_SALOMON_Social_and_behavioral_characteristics_of_male_blood_donors_2019.PDF (441.79 KB)
Citações na Scopus
2
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY
Autores
GOMES, Isabel
OZAHATA, Mina Cintho
MOREIRA, Carlos Henrique Valente
OLIVEIRA, Claudia Di Lorenzo
GONCALEZ, Thelma T.
DUARTE, Maria Esther
MIRANDA, Carolina
PROIETTI, Anna Barbara Carneiro
Citação
TRANSFUSION, v.59, n.8, p.2584-2592, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
BACKGROUND Men who have sex with men in Brazil are deferred from donation for 1 year since their last sexual contact. Legal proceedings in front of the Brazilian Supreme Court could compel blood collection agencies to discontinue use of sexual orientation questions. METHODS Data from male participants in a completed HIV risk factor case-control study were used to evaluate whether it is possible to differentiate donors at lower and higher risk for HIV using two analytical approaches: latent class and random forest analyses. RESULTS Male blood donors were divided into three distinct risk profile classes. Class 1 includes donors who are heterosexual (96.4%), are HIV negative (88.7%), have a main partner (99.4%), and practice unprotected sex (77.8%). Class 2 includes donors who are men who have sex with men /bisexuals' (100.0%), are HIV positive (97.4%), and were not aware of their sexual partners' HIV status (80.3%). Class 3 includes donors who are heterosexual (84.1%), practice unprotected vaginal/anal heterosexual sex (66.8% vs. 40.9%), and were both HIV positive and HIV negative (49.5% vs. 50.5%). We also found that asking donors about their partner(s)' HIV serostatus could replace asking about donors' sexual orientation and types of partners with relatively minor shifts in sensitivity (0.76 vs. 0.58), specificity (0.89 vs. 0.94), and positive predictive value (0.85 vs. 0.88). CONCLUSION Sexual orientation questions on the donor questionnaire could be replaced without great loss in the sensitivity, specificity, and positive predictive value. Social and sexual behaviors of donors and their partners are proxies for HIV risk and can help to develop modified questions that will need controlled trials to be validated.
Palavras-chave
URI
https://observatorio.fm.usp.br/handle/OPI/33492
Referências
  1. Alexander J, 2015, SEX TRANSM DIS, V42, P266, DOI 10.1097/OLQ.0000000000000266
  2. Benjamin RJ, 2011, VOX SANG, V101, P339, DOI 10.1111/j.1423-0410.2011.01489.x
  3. Blatyta PF, 2013, TRANSFUSION, V53, P2734, DOI 10.1111/trf.12166
  4. Boily MC, 2009, LANCET INFECT DIS, V9, P118, DOI 10.1016/S1473-3099(09)70021-0
  5. Brito A M, 2001, Rev Soc Bras Med Trop, V34, P207
  6. Chen C, 2004, USING RANDOM FOREST
  7. Conserve DF, 2014, AIDS CARE, V26, P1270, DOI 10.1080/09540121.2014.902422
  8. de Almeida C, 2007, TRANSFUSION, V47, P608, DOI 10.1111/j.1537-2995.2007.01161.x
  9. de Almeida-Neto C, 2013, VOX SANG, V105, P91, DOI 10.1111/vox.12028
  10. Galletly CL, 2012, AM J PUBLIC HEALTH, V102, P2135, DOI 10.2105/AJPH.2012.300664
  11. Goldman M, 2011, TRANSFUSION, V51, P1829, DOI 10.1111/j.1537-2995.2011.03078.x
  12. Jones A, 2014, LANCET, V384, P272, DOI 10.1016/S0140-6736(13)62230-8
  13. Kalichman SC, 2016, AIDS PATIENT CARE ST, V30, P221, DOI 10.1089/apc.2015.0333
  14. Latkin C, 2012, AIDS BEHAV, V16, P535, DOI 10.1007/s10461-011-0014-z
  15. Linzer DA, 2011, J STAT SOFTW, V42, P1
  16. Lunze K, 2013, AIDS BEHAV, V17, P390, DOI 10.1007/s10461-012-0216-z
  17. Ministerio da Saude (MS), 2017, B EP AIDS DST BRAS
  18. Niccolai LM, 1999, SEX TRANSM DIS, V26, P281, DOI 10.1097/00007435-199905000-00008
  19. Patavino GM, 2012, TRANSFUSION, V52, P151, DOI 10.1111/j.1537-2995.2011.03248.x
  20. Pinkerton SD, 2007, AIDS BEHAV, V11, P698, DOI 10.1007/s10461-006-9187-2
  21. Sabino EC, 2012, TRANSFUSION, V52, P870, DOI 10.1111/j.1537-2995.2011.03344.x
  22. Sanchez AM, 2003, TRANSFUSION, V43, P165, DOI 10.1046/j.1537-2995.2003.00295.x
  23. Suligoil B, 2013, BLOOD TRANSFUS-ITALY, V11, P441, DOI 10.2450/2013.0162-12
  24. Tassiopoulos K, 2013, CLIN INFECT DIS, V56, P283, DOI 10.1093/cid/cis816
  25. Trevor H, 2009, ELEMENT STAT LEARNIN, Vxxii, P745
  26. Vu L, 2012, AIDS BEHAV, V16, P132, DOI 10.1007/s10461-010-9873-y
  27. Young LE, 2017, AIDS BEHAV, V21, P2924, DOI 10.1007/s10461-017-1679-8

Coleções
Artigos e Materiais de Revistas Científicas - FM/MIP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - LIM/46
Artigos e Materiais de Revistas Científicas - ODS/03