ANTI-TRYPANOSOMAL ACTIVITY OF 1,2,3,4,6-PENTA-O-GALLOYL-beta-D-GLUCOSE ISOLATED FROM Plectranthus barbatus Andrews (Lamiaceae)
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Citações na Scopus
12
Tipo de produção
article
Data de publicação
2012
Título da Revista
ISSN da Revista
Título do Volume
Editora
SOC BRASILEIRA QUIMICA
Autores
SANTOS, Roberta T. dos
HIRAMOTO, Liliane L.
LAGO, Joao Henrique G.
SARTORELLI, Patricia
TEMPONE, Andre G.
LORENZI, Harri
Citação
QUIMICA NOVA, v.35, n.11, p.2229-2232, 2012
Resumo
MeOH extract from the leaves of Plectranthus barbatus Andrews (Lamiaceae), showed in vitro anti-trypanosomal activity. The bioassay-guided fractionation resulted in the isolation of a gallic acid derivative, identified as 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG), after thorough NMR and MS spectral analysis. Finally, this compound was tested against trypomastigote forms of T. cruzi and displayed an EC50 value of 67 mu M, at least 6.6-fold more effective than the standard drug benznidazole. This is the first occurrence of PGG in the Plectranthus genus and the first anti-parasitic activity described for PGG in the literature.
Palavras-chave
Plectranthus barbatus, 1,2,3,4,6-penta-O-galloyl-beta-D-glucose, anti-trypanosomal activity
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