Experimental models for identifying target events in vascular injury
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2021
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Girão-Silva, T.; Miyakawa, A. A.; Lacchini, S.. Experimental models for identifying target events in vascular injury. In: . ENDOTHELIAL SIGNALING IN VASCULAR DYSFUNCTION AND DISEASE: FROM BENCH TO BEDSIDE: ELSEVIER, 2021. p.179-193.
Resumo
The development of experimental models represent an excellent tool for the study and understanding of arterial and venous injuries associated with vascular pathologies as diverse as atherosclerosis and transplant rejection. With these models it was possible to understand the interference of the environment on vascular biology as well as to identify the the role of several regulatory factors from the initiation to the formation of complex lesions as atherosclerosis. The increase in hemodynamic forces, especially flow and pressure, triggers endothelial damage in the vascular bed, leading to vascular remodeling and ultimately to graft failure. In this chapter, we describe several experimental models available for in vivo, in vitro, and ex vivo studies. So far, many advances have been made, but more research is still needed. Due to methodological limitations, a multipronged approach is necessary for a comprehensive understanding of the mechanisms involved with vascular diseases, especially in the processes of stenosis, restenosis, and venous graft occlusion. © 2021 Elsevier Inc. All rights reserved.
Palavras-chave
Atherosclerosis, Cuff-induced injury, Inflammation, Neointima, Shear stress, Vein graft disease
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