Discovery of Novel miRNAs in Colorectal Cancer: Potential Biological Roles and Clinical Utility

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMINUTENTAG, Iael Weissberg
dc.contributor.authorSENEDA, Ana Laura
dc.contributor.authorBARROS-FILHOS, Mateus C.
dc.contributor.authorCARVALHO, Marcio de
dc.contributor.authorSOUZA, Vanessa G. P.
dc.contributor.authorHASIMOTO, Claudia N.
dc.contributor.authorMORAES, Marcelo P. T.
dc.contributor.authorMARCHI, Fabio A.
dc.contributor.authorLAM, Wan L.
dc.contributor.authorREIS, Patricia P.
dc.contributor.authorDRIGO, Sandra A.
dc.date.accessioned2024-02-15T14:55:05Z
dc.date.available2024-02-15T14:55:05Z
dc.date.issued2023
dc.description.abstractDeregulated miRNAs are associated with colorectal cancer (CRC), with alterations depending on the tumor location. Novel tissue-specific miRNAs have been identified in different tumors and are associated with cancer. We used miRMaster to identify novel miRNAs in CRC from the TCGA and GEO data (discovery and validation groups). We used TCGA data from five tissues to analyze miRNA tissue specificity. miRDB was used to predict miRNA targets, and the UCSC Xena Browser was used to evaluate target expression. After successive analyses, we identified 15 novel miRNAs with the same expression patterns in CRC in both the discovery and validation groups. Four molecules (nov-miR-13844-5p, nov-miR-7154-5p, nov-miR-5035-3p, and nov-miR-590-5p) were differentially expressed in proximal and distal CRC. The nov-miR-3345-5p and nov-miR-13172-3p, which are upregulated in tumors, are only expressed in colorectal tissues. These molecules have been linked to a worse prognosis in right-sided colon and rectal carcinomas. An analysis revealed an association between eight novel miRNAs and 81 targets, mostly cancer-related genes, with varying expression based on tumor location. These findings provide new miRNAs with potential biological relevance, molecular biomarkers, and therapeutic targets for CRC treatment.eng
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipCoordenao de Aperfeioamento de Pessoal de Nvel Superior/Coordination
dc.identifier.citationNON-CODING RNA, v.9, n.6, article ID 65, 16p, 2023
dc.identifier.doi10.3390/ncrna9060065
dc.identifier.eissn2311-553X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/58144
dc.language.isoeng
dc.publisherMDPIeng
dc.relation.ispartofNon-Coding Rna
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright MDPIeng
dc.subjectcolorectal cancereng
dc.subjecttumor locationeng
dc.subjectnovel microRNAeng
dc.subjectmiRMastereng
dc.subjecttissue specificityeng
dc.subjectprognosiseng
dc.subjectsmall-RNAseqeng
dc.subject.othertumor-suppressoreng
dc.subject.otherfragile siteseng
dc.subject.othermicrornaseng
dc.subject.otherlocationeng
dc.subject.othergeneeng
dc.subject.wosBiochemistry & Molecular Biologyeng
dc.subject.wosGenetics & Heredityeng
dc.titleDiscovery of Novel miRNAs in Colorectal Cancer: Potential Biological Roles and Clinical Utilityeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryCanadá
hcfmusp.affiliation.countryisoca
hcfmusp.author.externalMINUTENTAG, Iael Weissberg:Sao Paulo State Univ UNESP, Med Sch, Dept Surg & Orthoped, BR-18618687 Botucatu, Brazil; Sao Paulo State Univ UNESP, Expt Res Unity UNIPEX, BR-18618687 Botucatu, Brazil
hcfmusp.author.externalSENEDA, Ana Laura:Sao Paulo State Univ UNESP, Med Sch, Dept Surg & Orthoped, BR-18618687 Botucatu, Brazil; Sao Paulo State Univ UNESP, Expt Res Unity UNIPEX, BR-18618687 Botucatu, Brazil
hcfmusp.author.externalBARROS-FILHOS, Mateus C.:A C Camargo Canc Ctr, Ctr Int Pesquisa CIPE, BR-01508010 Sao Paulo, Brazil
hcfmusp.author.externalCARVALHO, Marcio de:Sao Paulo State Univ UNESP, Sch Vet Med & Anim Sci, BR-18618687 Botucatu, Brazil
hcfmusp.author.externalSOUZA, Vanessa G. P.:Sao Paulo State Univ UNESP, Expt Res Unity UNIPEX, BR-18618687 Botucatu, Brazil; Sao Paulo State Univ UNESP, Inst Biosci, Dept Genet, BR-18618687 Botucatu, Brazil
hcfmusp.author.externalHASIMOTO, Claudia N.:Sao Paulo State Univ UNESP, Med Sch, Dept Surg & Orthoped, BR-18618687 Botucatu, Brazil
hcfmusp.author.externalMORAES, Marcelo P. T.:Sao Paulo State Univ UNESP, Med Sch, Dept Surg & Orthoped, BR-18618687 Botucatu, Brazil; Sao Paulo State Univ UNESP, Med Sch, Dept Pathol, BR-18618687 Botucatu, Brazil
hcfmusp.author.externalLAM, Wan L.:British Columbia Canc Res Ctr, Vancouver, BC V5Z 1L3, Canada
hcfmusp.author.externalREIS, Patricia P.:Sao Paulo State Univ UNESP, Med Sch, Dept Surg & Orthoped, BR-18618687 Botucatu, Brazil; Sao Paulo State Univ UNESP, Expt Res Unity UNIPEX, BR-18618687 Botucatu, Brazil
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcFABIO ALBUQUERQUE MARCHI
hcfmusp.contributor.author-fmusphcSANDRA APARECIDA DRIGO LINDE
hcfmusp.description.articlenumber65
hcfmusp.description.issue6
hcfmusp.description.volume9
hcfmusp.origemWOS
hcfmusp.origem.pubmed37987361
hcfmusp.origem.scopus2-s2.0-85180507657
hcfmusp.origem.wosWOS:001131392900001
hcfmusp.publisher.cityBASELeng
hcfmusp.publisher.countrySWITZERLANDeng
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hcfmusp.scopus.lastupdate2024-05-17
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