The Role of Thyroid Gland Dysfunction in the Development of Keratoconus

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bookPart
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2022
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Scopus
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SPRINGER INTERNATIONAL PUBLISHING
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Stival, L. R. S.; Giacomin, N. T.; Santhiago, M. R.. The Role of Thyroid Gland Dysfunction in the Development of Keratoconus. In: . Keratoconus: A Comprehensive Guide to Diagnosis and Treatment: SPRINGER INTERNATIONAL PUBLISHING, 2022. p.29-37.
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The number of studies on the development of thyroid gland dysfunction and keratoconus highlights the multifactorial nature of the disease. Many factors seem to be related to keratoconus, such as genetic predisposition, inflammatory markers, environmental conditions, eye rubbing, and metabolic and structural changes, in addition to systemic diseases and hormonal changes. There seems to be evidence that hormonal changes caused by thyroid gland dysfunction are additional factors that, through influencing the corneal structure, could affect keratoconus progression. Thyroid hormones are regulated by the pituitary axis of the thyroid (HPT) and can be imbalanced, besides primary genetic defects, by activating factors that alter homeostasis such as pregnancy, thyroidectomy, or iodine therapy. In this chapter, we emphasize the scientific evidence related to thyroid hormones and the possible correlation to keratoconus. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.
Palavras-chave
Cornea, Keratoconus, Thyroid gland dysfunction, Thyroid-stimulating hormone, Thyroxine
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https://observatorio.fm.usp.br/handle/OPI/57231
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