Pathological macroscopic evaluation of breast density versus mammographic breast density in breast cancer conserving surgery

Correlation between imaging and anatomopathological breast density has been superficially explored and is heterogeneous in current medical literature. It is possible that mammographic and pathological findings are divergent. The aim of this study is to evaluate the association between breast density classified by mammography and breast density of pathological macroscopic examination in specimens of breast cancer conservative surgeries. Post-hoc, exploratory analysis of a prospective randomized clinical trial of patients with breast cancer candidates for breast conservative surgery. Breast mammographic density (MD) was analyzed according to ACR BI-RADS (R) criteria, and pathologic macroscopic evaluation of breast density (PMBD) was estimated by visually calculating the ratio between stromal and fatty tissue. From 412 patients, MD was A in 291 (70,6%), B in 80 (19,4%) B, C in 35 (8,5%), and D in 6 (1,5%). Ninety-nine percent (201/203) of patients classified as A+B in MD were correspondently classified in PMBD. Conversely, only 18.7% (39/209) of patients with MD C+D were classified correspondently in PMBD (p < 0.001). Binary logistic regression showed age (OR 1.06, 1.01-1.12 95% CI, p 0.013) and nulliparity (OR 0.39, 0.17-0.96 95% CI, p 0.039) as predictors of A+B PMBD.Conclusion: Mammographic and pathologic macroscopic breast density showed no association in our study for breast C or D in breast image. The fatty breast was associated with older patients and the nulliparity decreases the chance of fatty breasts nearby 60%.

Palavras-chave

Breast neoplasms, Breast density, Pathology, Mammography

URI

https://observatorio.fm.usp.br/handle/OPI/57467

Referências

Alowami S, 2003, BREAST CANCER RES, V5, pR129, DOI 10.1186/bcr622
Bodewes FTH, 2022, BREAST, V66, P62, DOI 10.1016/j.breast.2022.09.007
Boyd NF, 2010, JNCI-J NATL CANCER I, V102, P1224, DOI 10.1093/jnci/djq239
BRIGHT RA, 1988, CANCER, V61, P266, DOI 10.1002/1097-0142(19880115)61:2<266::AID-CNCR2820610212>3.0.CO;2-N
Carney PA, 2003, ANN INTERN MED, V138, P168, DOI 10.7326/0003-4819-138-3-200302040-00008
Ekpo EU, 2015, RADIOGRAPHY, V21, P324, DOI 10.1016/j.radi.2015.06.006
Ghosh K, 2017, BREAST CANCER RES, V19, DOI 10.1186/s13058-017-0922-6
Ghosh K, 2012, BREAST CANCER RES TR, V131, P267, DOI 10.1007/s10549-011-1727-4
Ghosh K, 2010, JNCI-J NATL CANCER I, V102, P1716, DOI 10.1093/jnci/djq414
Gierach GL, 2016, CANCER PREV RES, V9, P149, DOI 10.1158/1940-6207.CAPR-15-0282
Harvey JA, 2008, MENOPAUSE, V15, P67, DOI 10.1097/gme.0b013e318054e29a
Huo CW, 2014, BREAST CANCER RES TR, V144, P479, DOI 10.1007/s10549-014-2901-2
Ironside AJ, 2016, ONCOTARGET, V7, P31550, DOI 10.18632/oncotarget.6912
Lee CI, 2017, MED CLIN N AM, V101, P725, DOI 10.1016/j.mcna.2017.03.005
Li T, 2005, CANCER EPIDEM BIOMAR, V14, P343, DOI 10.1158/1055-9965.EPI-04-0490
Mann RM, 2022, EUR RADIOL, V32, P4036, DOI 10.1007/s00330-022-08617-6
McCormack VA, 2006, CANCER EPIDEM BIOMAR, V15, P1159, DOI 10.1158/1055-9965.EPI-06-0034
Moher D, 2001, JAMA-J AM MED ASSOC, V285, P1987, DOI 10.1001/jama.285.15.1987
Mota BS, 2023, BREAST CANCER RES TR, V198, P447, DOI 10.1007/s10549-023-06884-5
Van Goethem M, 2004, EUR RADIOL, V14, P1363, DOI 10.1007/s00330-004-2295-3
WELLINGS SR, 1978, RADIOLOGY, V129, P299, DOI 10.1148/129.2.299
Winkler NS, 2015, RADIOGRAPHICS, V35, P316, DOI 10.1148/rg.352140134

Coleções

Artigos e Materiais de Revistas Científicas - FM/MOG
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/24
Artigos e Materiais de Revistas Científicas - LIM/58
Artigos e Materiais de Revistas Científicas - ODS/03

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