DEVELOPMENT OF A BIOLOGIC DRESSING FOR THE TREATMENT OF SKIN ULCERS ASSOCIATED TO HLA CLASS I DEFICIENCY
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Tipo de produção
conferenceObject
Data de publicação
2012
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER/PLENUM PUBLISHERS
Citação
JOURNAL OF CLINICAL IMMUNOLOGY, v.32, suppl.1, p.147-148, 2012
Resumo
Human leukocyte antigen class I (HLA-I) deficiency is a rare disease (less than 30 reported cases in the world) with remarkable clinical and biological heterogeneity. It presents a 90-99% reduction reduction in the expression of HLA-I molecules. This syndrome is caused by defects in TAP-1, TAP-2 and Tapasin (MIM 604571). Although asymptomatic cases have been described, HLA-I deficiencies are usually characterized by chronic bacterial infections of the upper and lower airways, evolving to bronchiectasis, and also necrotizing granulomatous skin lesions. Treatment is addressed to controlling infections. Early and prolonged use of antibiotics should be performed at the first sign of infection. Some patients have benefited from immunoglobulin therapy. The lack of adequate treatments for the cure of disease associated with the fact we do not have as well effective therapy for the necrotizing granulomatous lesions of the skin, directed us to look for alternatives for the treatment of these recalcitrant and disabling injuries. Considering the necessity of developing new skin substitutes for the treatment of major tissue loss in patients with deficiencies of MHC class I with large granulation tissue areas, it is proposed in this study the in vivo use of biological dressings made of denuded amniotic membranes as a substrate for the growth of a epidermal layer formed by keratinocytes of the patients, allowing the growth of epithelia from the recalcitrant wounds of granulomatous lesions presented by people with MHC class I deficiency.