First report of putative <i>Leishmania</i> RNA virus 2 (LRV2) in <i>Leishmania infantum</i> strains from canine and human visceral leishmaniasis cases in the southeast of Brazil

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art_REGO_First_report_of_putative_iLeishmaniai_RNA_virus_2_2023.PDF (1.08 MB)
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0
Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
FUNDACO OSWALDO CRUZ
Autores
REGO, Felipe Dutra
SILVA, Eduardo Sergio da
LOPES, Valeriana Valadares
TEIXEIRA-NETO, Rafael Goncalves
BELO, Vinicius Silva
JR, Antonio Augusto Fonseca
PEREIRA, Diego Andrade
PENA, Heber Paulino
Citação
MEMORIAS DO INSTITUTO OSWALDO CRUZ, v.118, article ID e230071, 8p, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
BACKGROUND Leishmania RNA virus 1 (LRV1) is commonly found in South American Leishmania parasites belonging to the subgenus Viannia, whereas Leishmania RNA virus 2 (LRV2) was previously thought to be restricted to the Old-World pathogens of the subgenus Leishmania. OBJECTIVES In this study, we investigated the presence of LRV2 in strains of Leishmania (L.) infantum, the causative agent of visceral leishmaniasis (VL), originating from different hosts, clinical forms, and geographical regions. METHODS A total of seventy-one isolates were screened for LRV2 using semi-nested reverse transcription-polymerase chain reaction (RT-PCR) targeting the RNA-dependent RNA polymerase (RdRp) gene. FINDINGS We detected LRV2 in two L. infantum isolates (CUR268 and HP-EMO) from canine and human cases, respectively. MAIN CONCLUSIONS To the best of our knowledge, this is the first detection of LRV2 in the New World.
Palavras-chave
Leishmania, Leishmania infantum, leishmaniasis, Leishmania RNA virus, Totiviridae
URI
https://observatorio.fm.usp.br/handle/OPI/57519
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/50