Metagenomic of Liver Tissue Identified at Least Two Genera of Totivirus-like Viruses in <i>Molossus molossus</i> Bats

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Tipo de produção
article
Data de publicação
2024
DOI
Scopus
Web of Science
PubMed
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Título do Volume
Editora
MDPI
Autores
COUTO, Roseane da Silva
RAMOS, Endrya do Socorro Foro
ABREU, Wandercleyson Uchoa
RODRIGUES, Luis Reginaldo Ribeiro
MARINHO, Luis Fernando
VILLANOVA, Fabiola
PANDEY, Ramendra Pati
DENG, Xutao
DELWART, Eric
Citação
MICROORGANISMS, v.12, n.1, article ID 206, 14p, 2024
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The Totiviridae family of viruses has a unique genome consisting of double-stranded RNA with two open reading frames that encode the capsid protein (Cap) and the RNA-dependent RNA polymerase (RdRpol). Most virions in this family are isometric in shape, approximately 40 nm in diameter, and lack an envelope. There are five genera within this family, including Totivirus, Victorivirus, Giardiavirus, Leishmaniavirus, and Trichomonasvirus. While Totivirus and Victorivirus primarily infect fungi, Giardiavirus, Leishmaniavirus, and Trichomonasvirus infect diverse hosts, including protists, insects, and vertebrates. Recently, new totivirus-like species have been discovered in fish and plant hosts, and through metagenomic analysis, a novel totivirus-like virus (named Tianjin totivirus) has been isolated from bat guano. Interestingly, Tianjin totivirus causes cytopathic effects in insect cells but cannot grow in mammalian cells, suggesting that it infects insects consumed by insectivorous bats. In this study, we used next-generation sequencing and identified totivirus-like viruses in liver tissue from Molossus molossus bats in the Amazon region of Brazil. Comparative phylogenetic analysis based on the RNA-dependent RNA polymerase region revealed that the viruses identified in Molossus bats belong to two distinct phylogenetic clades, possibly comprising different genera within the Totiviridae family. Notably, the mean similarity between the Tianjin totivirus and the totiviruses identified in Molossus bats is less than 18%. These findings suggest that the diversity of totiviruses in bats is more extensive than previously recognized and highlight the potential for bats to serve as reservoirs for novel toti-like viruses.
Palavras-chave
metagenomics, totivirus, bats, molossus, amazon region
URI
https://observatorio.fm.usp.br/handle/OPI/59044
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Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros
Artigos e Materiais de Revistas Científicas - COVID-19