Chagas Cardiomyopathy
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bookPart
Data de publicação
2017
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ELSEVIER INC.
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Citação
Fernandes, F.; Moreira, C. H. V.; Barbosa-Ferreira, J. M.; Sabino, E. C.. Chagas Cardiomyopathy. In: . THE HEART IN RHEUMATIC, AUTOIMMUNE AND INFLAMMATORY DISEASES: PATHOPHYSIOLOGY, CLINICAL ASPECTS AND THERAPEUTIC APPROACHES: ELSEVIER INC., 2017. p.553-574.
Resumo
Chagas disease is one of the most important parasitic infections in South America. Trypanosoma cruzi is the protozoan implicated in the development of ChD. Persistent low-grade parasitemia, accompanied by an unbalanced immune response, appears to be the main pathogenic mechanism underlying myocardial damage, microvascular dysfunction, and neuronal cell loss. Chronic phase can be divided into four clinical forms: indeterminate, cardiac, digestive, and mixed (cardiac and digestive impairment in the same patient). Although chronic Chagas' cardiomyopathy is an important cause of heart failure in Latin America and is a unique clinical entity with unique therapeutic characteristics, these patients have not been included in large-scale studies assessing drugs to treat heart failure. Thus the real efficacy and tolerability of these drugs in these patients have not been scientifically established and their use has been extrapolated empirically from the results obtained for heart failure due to other etiologies. © 2017 Elsevier Inc. All rights reserved.
Palavras-chave
Angiotensin-converting-enzyme, Antitrypanosomal therapy, Beta-blockers, Blood transfusion, Cardiac transplantation, Cellular transplantation, Chagas disease, Congenital, Diuretics, Echocardiography, Electrocardiography, Myocardial fibrosis, Nuclear medicine, Oral transmission, Organ transplantation, Trypanosoma cruzi, Trypomastigotes
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