SPECT and PET in eating disorders

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2014
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SPRINGER BERLIN HEIDELBERG
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WAARDE, A. van
AUDENAERT, K.
DIERCKX, R. A. J. O.
Citação
van Waarde, A.; Audenaert, K.; Busatto, G. F.; Buchpiguel, C.; Dierckx, R. A. J. O.. SPECT and PET in eating disorders. In: . PET AND SPECT IN PSYCHIATRY: SPRINGER BERLIN HEIDELBERG, 2014. p.555-581.
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Medical imaging techniques like PET and SPECT have been applied for investigation of brain function in anorexia and bulimia nervosa. Regional abnormalities have been detected in cerebral blood fl ow, glucose metabolism, the availability of several neurotransmitter receptors (serotonin 1A and 2A, dopamine D2/D3, histamine H1, mu-opioid, and cannabinoid CB1), stimulant- induced dopamine release, and the density of serotonin transporters. Different subtypes of eating disorders appear to be associated with specifi c functional changes. It is hard to judge whether such changes are a consequence of chronic dietary restrictions or are caused by a putative anorexia (or bulimia) nervosa endophenotype. Many abnormalities (particularly those of glucose metabolism) appear to be reversible after restoration of weight or normal patterns of food intake and may represent consequences of purging or starvation. However, some changes of regional fl ow and neurotransmitter systems persist even after successful therapy which suggests that these refl ect traits that are independent of the state of the illness. Changes of the serotonergic system (altered activity of 5-HT 1A and 5-HT 2A receptors and 5-HT transporters) may contribute to dysregulation of appetite, mood, and impulse control in eating disorders and may represent a trait which predisposes to the development of anxiety, obsessionality, and behavioral inhibition. Assessment of functional changes in the brain with PET or SPECT may have prognostic value and predict neuropsychological status after several years of therapy. © Springer-Verlag Berlin Heidelberg 2014.
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Referências
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