SPECT and PET in eating disorders
Nenhuma Miniatura disponível
Citações na Scopus
0
Tipo de produção
bookPart
Data de publicação
2014
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER BERLIN HEIDELBERG
Autores
Citação
van Waarde, A.; Audenaert, K.; Busatto, G. F.; Buchpiguel, C.; Dierckx, R. A. J. O.. SPECT and PET in eating disorders. In: . PET AND SPECT IN PSYCHIATRY: SPRINGER BERLIN HEIDELBERG, 2014. p.555-581.
Resumo
Medical imaging techniques like PET and SPECT have been applied for investigation of brain function in anorexia and bulimia nervosa. Regional abnormalities have been detected in cerebral blood fl ow, glucose metabolism, the availability of several neurotransmitter receptors (serotonin 1A and 2A, dopamine D2/D3, histamine H1, mu-opioid, and cannabinoid CB1), stimulant- induced dopamine release, and the density of serotonin transporters. Different subtypes of eating disorders appear to be associated with specifi c functional changes. It is hard to judge whether such changes are a consequence of chronic dietary restrictions or are caused by a putative anorexia (or bulimia) nervosa endophenotype. Many abnormalities (particularly those of glucose metabolism) appear to be reversible after restoration of weight or normal patterns of food intake and may represent consequences of purging or starvation. However, some changes of regional fl ow and neurotransmitter systems persist even after successful therapy which suggests that these refl ect traits that are independent of the state of the illness. Changes of the serotonergic system (altered activity of 5-HT 1A and 5-HT 2A receptors and 5-HT transporters) may contribute to dysregulation of appetite, mood, and impulse control in eating disorders and may represent a trait which predisposes to the development of anxiety, obsessionality, and behavioral inhibition. Assessment of functional changes in the brain with PET or SPECT may have prognostic value and predict neuropsychological status after several years of therapy. © Springer-Verlag Berlin Heidelberg 2014.
Palavras-chave
Referências
- (2000) Diagnostic and statistical manual of mental disorders, , American Psychiatric Association, Washington, DC
- Andreason, P.J., Altemus, M., Zametkin, A.J., King, A.C., Lucinio, J., Cohen, R.M., Regional cerebral glucose metabolism in bulimia nervosa (1992) Am J Psychiatry, 149, pp. 1506-1513
- Audenaert, K., Van Laere, K., Dumont, F., Vervaet, M., Goethals, I., Slegers, G., Mertens, J., Dierckx, R.A., Decreased 5-HT 2a receptor binding in patients with anorexia nervosa (2003) J Nucl Med, 44, pp. 163-169
- Bailer, U.F., Kaye, W.H., Serotonin: Imaging findings in eating disorders (2011) Curr Top Behav Neurosci, 6, pp. 59-79
- Bailer, U.F., Price, J.C., Meltzer, C.C., Mathis, C.A., Frank, G.K., Weissfeld, L., McConaha, C.W., Kaye, W.H., Altered 5-HT(2A) receptor binding after recovery from bulimia-type anorexia nervosa: Relationships to harm avoidance and drive for thinness (2004) Neuropsychopharmacology, 29, pp. 1143-1155
- Bailer, U.F., Frank, G.K., Henry, S.E., Price, J.C., Meltzer, C.C., Weissfeld, L., Mathis, C.A., Kaye, W.H., Altered brain serotonin 5-HT 1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635 (2005) Arch Gen Psychiatry, 62, pp. 1032-1041
- Bailer, U.F., Frank, G.K., Henry, S.E., Price, J.C., Meltzer, C.C., Becker, C., Ziolko, S.K., Kaye, W.H., Serotonin transporter binding after recovery from eating disorders (2007) Psychopharmacology (Berl), 195, pp. 315-324
- Bailer, U.F., Frank, G.K., Henry, S.E., Price, J.C., Meltzer, C.C., Mathis, C.A., Wagner, A., Kaye, W.H., Exaggerated 5-HT 1A but normal 5-HT 2A receptor activity in individuals ill with anorexia nervosa (2007) Biol Psychiatry, 61, pp. 1090-1099
- Bailer, U.F., Bloss, C.S., Frank, G.K., Price, J.C., Meltzer, C.C., Mathis, C.A., Geyer, M.A., Kaye, W.H., 5-HT(1)A receptor binding is increased after recovery from bulimia nervosa compared to control women and is associated with behavioral inhibition in both groups (2011) Int J Eat Disord, 44, pp. 477-487
- Bailer, U.F., Narendran, R., Frankle, W.G., Himes, M.L., Duvvuri, V., Mathis, C.A., Kaye, W.H., Amphetamine induced dopamine release increases anxiety in individuals recovered from anorexia nervosa (2012) Int J Eat Disord, 45, pp. 263-271
- Bailer, U.F., Frank, G.K., Price, J.C., Meltzer, C.C., Becker, C., Mathis, C.A., Wagner, A., Kaye, W.H., Interaction between serotonin transporter and dopamine D2/D3 receptor radioligand measures is associated with harm avoidant symptoms in anorexia and bulimia nervosa (2013) Psychiatry Res, 211, pp. 160-168
- Barbarich, N.C., Kaye, W.H., Jimerson, D., Neurotransmitter and imaging studies in anorexia nervosa: New targets for treatment (2003) Curr Drug Targets CNS Neurol Disord, 2, pp. 61-72
- Barbarich-Marsteller, N.C., Marsteller, D.A., Alexoff, D.L., Fowler, J.S., Dewey, S.L., MicroPET imaging in an animal model of anorexia nervosa (2005) Synapse, 57, pp. 85-90
- Beato-Fernandez, L., Rodriguez-Cano, T., Garcia-Vilches, I., Garcia-Vicente, A., Poblete-Garcia, V., Castrejon, A.S., Toro, J., Changes in regional cerebral blood flow after body image exposure in eating disorders (2009) Psychiatry Res, 171, pp. 129-137
- Bencherif, B., Guarda, A.S., Colantuoni, C., Ravert, H.T., Dannals, R.F., Frost, J.J., Regional muopioid receptor binding in insular cortex is decreased in bulimia nervosa and correlates inversely with fasting behavior (2005) J Nucl Med, 46, pp. 1349-1351
- Broft, A., Shingleton, R., Kaufman, J., Liu, F., Kumar, D., Slifstein, M., Abi-Dargham, A., Walsh, B.T., Striatal dopamine in bulimia nervosa: A PET imaging study (2012) Int J Eat Disord, 45, pp. 648-656
- Chowdhury, U., Gordon, I., Lask, B., Watkins, B., Watt, H., Christie, D., Early-onset anorexia nervosa: Is there evidence of limbic system imbalance? (2003) Int J Eat Disord, 33, pp. 388-396
- Delvenne, V., Lotstra, F., Goldman, S., Biver, F., De Maertalaer, V., Ppelboom-Fondu, J., Schoutens, A., Mendelwicz, J., Brain hypometabolism of glucose in anorexia nervosa: A PET scan study (1995) Biol Psychiatry, 37, pp. 161-169
- Delvenne, V., Goldman, S., De Maertalaer, V., Simon, Y., Luxen, A., Lotstra, F., Brain hypometabolism of glucose in anorexia nervosa: Normalization after weight gain (1996) Biol Psychiatry, 40, pp. 761-768
- Delvenne, V., Goldman, S., Biver, F., De Maertalaer, V., Wikler, D., Damhaut, P., Lotstra, F., Brain hypometabolism of glucose in low-weight depressed patients and in anorectic patients: A consequence of starvation? (1997) J Affect Disord, 44, pp. 69-77
- Delvenne, V., Goldman, S., De Maertalaer, V., Wikler, D., Damhaut, P., Lotstra, F., Brain glucose metabolism in anorexia nervosa and affective disorders: Influence of weight loss or depressive symptomatology (1997) Psychiatry Res, 74, pp. 83-92
- Delvenne, V., Goldman, S., Simon, Y., De Maertalaer, V., Lotstra, F., Brain hypometabolism of glucose in bulimia nervosa (1997) Int J Eat Disord, 21, pp. 313-320
- Delvenne, V., Goldman, S., De Maertalaer, V., Lotstra, F., Brain glucose metabolism in eating disorders assessed by positron emission tomography (1999) Int J Eat Disord, 25, pp. 29-37
- Faris, P.L., Eckert, E.D., Kim, S.W., Meller, W.H., Pardo, J.V., Goodale, R.L., Hartman, B.K., Evidence for a vagal pathophysiology for bulimia nervosa and the accompanying depressive symptoms (2006) J Affect Disord, 92, pp. 79-90
- Ferro, A.M., Brugnolo, A., De, L.C., Dessi, B., Girtler, N., Morbelli, S., Nobili, F., Rodriguez, G., Stroop interference task and single-photon emission tomography in anorexia: A preliminary report (2005) Int J Eat Disord, 38, pp. 323-329
- Frampton, I., Watkins, B., Gordon, I., Lask, B., Do abnormalities in regional cerebral blood flow in anorexia nervosa resolve after weight restoration? (2011) Eur Eat Disord Rev, 19, pp. 55-58
- Frampton, I., Hutchinson, A., Watkins, B., Lask, B., Neurobiological status at initial presentation predicts neuropsychological functioning in early onset anorexia nervosa at four-year follow up (2012) Dev Neuropsychol, 37, pp. 76-83
- Frank, G.K., Advances in the diagnosis of anorexia nervosa and bulimia nervosa using brain imaging (2012) Expert Opin Med Diagn, 6, pp. 235-244
- Frank, G.K., Kaye, W.H., Current status of functional imaging in eating disorders (2012) Int J Eat Disord, 45, pp. 723-736
- Frank, G.K., Kaye, W.H., Greer, P., Meltzer, C.C., Price, J.C., Regional cerebral blood flow after recovery from bulimia nervosa (2000) Psychiatry Res, 100, pp. 31-39
- Frank, G.K., Kaye, W.H., Meltzer, C.C., Price, J.C., Greer, P., McConaha, C., Skovira, K., Reduced 5-HT2Areceptor binding after recovery from anorexia nervosa (2002) Biol Psychiatry, 52, pp. 896-906
- Frank, G.K., Bailer, U.F., Henry, S.E., Drevets, W., Meltzer, C.C., Price, J.C., Mathis, C.A., Kaye, W.H., Increased dopamine D2/D3 receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [11C]raclopride (2005) Biol Psychiatry, 58, pp. 908-912
- Frank, G.K., Wagner, A., Achenbach, S., McConaha, C., Skovira, K., Aizenstein, H., Carter, C.S., Kaye, W.H., Altered brain activity in women recovered from bulimic-type eating disorders after a glucose challenge: A pilot study (2006) Int J Eat Disord, 39, pp. 76-79
- Frank, G.K., Bailer, U.F., Meltzer, C.C., Price, J.C., Mathis, C.A., Wagner, A., Becker, C., Kaye, W.H., Regional cerebral blood flow after recovery from anorexia or bulimia nervosa (2007) Int J Eat Disord, 40, pp. 488-492
- Freeman, C.P., Hampson, M., Fluoxetine as a treatment for bulimia nervosa (1987) Int J Obes, 11, pp. 171-177
- Galusca, B., Costes, N., Zito, N.G., Peyron, R., Bossu, C., Lang, F., Le, B.D., Estour, B., Organic background of restrictive-type anorexia nervosa suggested by increased serotonin 1A receptor binding in right frontotemporal cortex of both lean and recovered patients: [18F] MPPF PET scan study (2008) Biol Psychiatry, 64, pp. 1009-1013
- Gerard, N., Pieters, G., Goffin, K., Bormans, G., Van Laere, K., Brain type 1 cannabinoid receptor availability in patients with anorexia and bulimia nervosa (2011) Biol Psychiatry, 70, pp. 777-784
- Goethals, I., Vervaet, M., Audenaert, K., Van de Wiele, C., Ham, H., Vandecapelle, M., Slegers, G., Van Heeringen, C., Comparison of cortical 5-HT 2A receptor binding in bulimia nervosa patients and healthy volunteers (2004) Am J Psychiatry, 161, pp. 1916-1918
- Goethals, I., Vervaet, M., Audenaert, K., Jacobs, F., Ham, H., Van de Wiele, C., Vandecapelle, M., Van Heeringen, C., Differences of cortical 5-HT 2A receptor binding index with SPECT in subtypes of anorexia nervosa: Relationship with personality traits? (2007) J Psychiatr Res, 41, pp. 455-458
- Goethals, I., Vervaet, M., Audenaert, K., Jacobs, F., Ham, H., Van Heeringen, C., Does regional brain perfusion correlate with eating disorder symptoms in anorexia and bulimia nervosa patients? (2007) J Psychiatr Res, 41, pp. 1005-1011
- Goldbloom, D.S., Hicks, L.K., Garfinkel, P.E., Platelet serotonin uptake in bulimia nervosa (1990) Biol Psychiatry, 28, pp. 644-647
- Gordon, I., Lask, B., Bryant-Waugh, R., Christie, D., Timimi, S., Childhood-onset anorexia nervosa: Towards identifying a biological substrate (1997) Int J Eat Disord, 22, pp. 159-165
- Gordon, C.M., Dougherty, D.D., Fischman, A.J., Emans, S.J., Grace, E., Lamm, R., Alpert, N.M., Rauch, S.L., Neural substrates of anorexia nervosa: A behavioral challenge study with positron emission tomography (2001) J Pediatr, 139, pp. 51-57
- Hagman, J.O., Buchsbaum, M.S., Wu, J.C., Rao, S.J., Reynolds, C.A., Blinder, B.J., Comparison of regional brain metabolism in bulimia nervosa and affective disorder assessed with positron emission tomography (1990) J Affect Disord, 19, pp. 153-162
- Heaner, M.K., Walsh, B.T., A history of the identification of the characteristic eating disturbances of Bulimia Nervosa, Binge Eating Disorder and Anorexia Nervosa (2013) Appetite, 65, pp. 185-188
- Herholz, K., Krieg, J.C., Emrich, H.M., Pawlik, G., Beil, C., Pirke, K.M., Pahl, J.J., Ploog, D., Regional cerebral glucose metabolism in anorexia nervosa measured by positron emission tomography (1987) Biol Psychiatry, 22, pp. 43-51
- Hirano, H., Tomura, N., Okane, K., Watarai, J., Tashiro, T., Changes in cerebral blood flow in bulimia nervosa (1999) J Comput Assist Tomogr, 23, pp. 280-282
- Jauregui-Lobera, I., Neuroimaging in eating disorders (2011) Neuropsychiatr Dis Treat, 7, pp. 577-584
- Kasper, S., Tauscher, J., Willeit, M., Stamenkovic, M., Neumeister, A., Kufferle, B., Barnas, C., Brucke, T., Receptor and transporter imaging studies in schizophrenia, depression, bulimia and Tourette's disorder - implications for psychopharmacology (2002) World J Biol Psychiatry, 3, pp. 133-146
- Kaye, W., Neurobiology of anorexia and bulimia nervosa (2008) Physiol Behav, 94, pp. 121-135
- Kaye, W.H., Frank, G.K., Meltzer, C.C., Price, J.C., McConaha, C.W., Crossan, P.J., Klump, K.L., Rhodes, L., Altered serotonin 2A receptor activity in women who have recovered from bulimia nervosa (2001) Am J Psychiatry, 158, pp. 1152-1155
- Kaye, W.H., Bailer, U.F., Frank, G.K., Wagner, A., Henry, S.E., Brain imaging of serotonin after recovery from anorexia and bulimia nervosa (2005) Physiol Behav, 86, pp. 15-17
- Kaye, W.H., Frank, G.K., Bailer, U.F., Henry, S.E., Meltzer, C.C., Price, J.C., Mathis, C.A., Wagner, A., Serotonin alterations in anorexia and bulimia nervosa: New insights from imaging studies (2005) Physiol Behav, 85, pp. 73-81
- Kojima, S., Nagai, N., Nakabeppu, Y., Muranaga, T., Deguchi, D., Nakajo, M., Masuda, A., Naruo, T., Comparison of regional cerebral blood flow in patients with anorexia nervosa before and after weight gain (2005) Psychiatry Res, 140, pp. 251-258
- Komatsu, H., Nagamitsu, S., Ozono, S., Yamashita, Y., Ishibashi, M., Matsuishi, T., Regional cerebral blood flow changes in early-onset anorexia nervosa before and after weight gain (2010) Brain Dev, 32, pp. 625-630
- Krieg, J.C., Lauer, C., Leinsinger, G., Pahl, J., Schreiber, W., Pirke, K.M., Moser, E.A., Brain morphology and regional cerebral blood flow in anorexia nervosa (1989) Biol Psychiatry, 25, pp. 1041-1048
- Krieg, J.C., Holthoff, V., Schreiber, W., Pirke, K.M., Herholz, K., Glucose metabolism in the caudate nuclei of patients with eating disorders, measured by PET (1991) Eur Arch Psychiatry Clin Neurosci, 240, pp. 331-333
- Kuikka, J.T., Tammela, L., Karhunen, L., Rissanen, A., Bergstrom, K.A., Naukkarinen, H., Vanninen, E., Uusitupa, M., Reduced serotonin transporter binding in binge eating women (2001) Psychopharmacology (Berl), 155, pp. 310-314
- Kuruoglu, A.C., Kapucu, O., Atasever, T., Arikan, Z., Isik, E., Unlu, M., Technetium-99m-HMPAO brain SPECT in anorexia nervosa (1998) J Nucl Med, 39, pp. 304-306
- Lask, B., Gordon, I., Christie, D., Frampton, I., Chowdhury, U., Watkins, B., Functional neuroimaging in early-onset anorexia nervosa (2005) Int J Eat Disord, 37, pp. S49-S51
- Leibowitz, S.F., Brain monoamines and peptides: Role in the control of eating behavior (1986) Fed Proc, 45, pp. 1396-1403
- Lipsman, N., Woodside, D.B., Giacobbe, P., Hamani, C., Carter, J.C., Norwood, S.J., Sutandar, K., Lozano, A.M., Subcallosal cingulate deep brain stimulation for treatment-refractory anorexia nervosa: A phase 1 pilot trial (2013) Lancet, 381, pp. 1361-1370
- Lundgren, J.D., Newberg, A.B., Allison, K.C., Wintering, N.A., Ploessl, K., Stunkard, A.J., 123 I-ADAM SPECT imaging of serotonin transporter binding in patients with night eating syndrome: A preliminary report (2008) Psychiatry Res, 162, pp. 214-220
- Marco, E.M., Romero-Zerbo, S.Y., Viveros, M.P., Bermudez-Silva, F.J., The role of the endocannabinoid system in eating disorders: Pharmacological implications (2012) Behav Pharmacol, 23, pp. 526-536
- Matsumoto, R., Kitabayashi, Y., Narumoto, J., Wada, Y., Okamoto, A., Ushijima, Y., Yokoyama, C., Fukui, K., Regional cerebral blood flow changes associated with interoceptive awareness in the recovery process of anorexia nervosa (2006) Prog Neuropsychopharmacol Biol Psychiatry, 30, pp. 1265-1270
- Merrall, N.W., Plevin, R., Gould, G.W., Growth factors, mitogens, oncogenes and the regulation of glucose transport (1993) Cell Signal, 5, pp. 667-675
- Miller, K.K., Deckersbach, T., Rauch, S.L., Fischman, A.J., Grieco, K.A., Herzog, D.B., Klibanski, A., Testosterone administration attenuates regional brain hypometabolism in women with anorexia nervosa (2004) Psychiatry Res, 132, pp. 197-207
- Naruo, T., Nakabeppu, Y., Sagiyama, K., Munemoto, T., Homan, N., Deguchi, D., Nakajo, M., Nozoe, S., Characteristic regional cerebral blood flow patterns in anorexia nervosa patients with binge/purge behavior (2000) Am J Psychiatry, 157, pp. 1520-1522
- Naruo, T., Nakabeppu, Y., Deguchi, D., Nagai, N., Tsutsui, J., Nakajo, M., Nozoe, S., Decreases in blood perfusion of the anterior cingulate gyri in Anorexia Nervosa Restricters assessed by SPECT image analysis (2001) BMC Psychiatry, 1, p. 2
- Nozoe, S., Naruo, T., Nakabeppu, Y., Soejima, Y., Nakajo, M., Tanaka, H., Changes in regional cerebral blood flow in patients with anorexia nervosa detected through single photon emission tomography imaging (1993) Biol Psychiatry, 34, pp. 578-580
- Nozoe, S., Naruo, T., Yonekura, R., Nakabeppu, Y., Soejima, Y., Nagai, N., Nakajo, M., Tanaka, H., Comparison of regional cerebral blood flow in patients with eating disorders (1995) Brain Res Bull, 36, pp. 251-255
- O'Brien, A., Hugo, P., Stapleton, S., Lask, B., ""Anorexia saved my life"": Coincidental anorexia nervosa and cerebral meningioma (2001) Int J Eat Disord, 30, pp. 346-349
- Pichika, R., Buchsbaum, M.S., Bailer, U., Hoh, C., Decastro, A., Buchsbaum, B.R., Kaye, W., Serotonin transporter binding after recovery from bulimia nervosa (2012) Int J Eat Disord, 45, pp. 345-352
- Rastam, M., Bjure, J., Vestergren, E., Uvebrant, P., Gillberg, I.C., Wentz, E., Gillberg, C., Regional cerebral blood flow in weight-restored anorexia nervosa: A preliminary study (2001) Dev Med Child Neurol, 43, pp. 239-242
- Rodriguez-Cano, T., Beato-Fernandez, L., Garcia-Vilches, I., Garcia-Vicente, A., Poblete-Garcia, V., Soriano-Castrejon, A., Regional cerebral blood flow patterns of change following the own body image exposure in eating disorders: A longitudinal study (2009) Eur Psychiatry, 24, pp. 275-281
- Roux, H., Chapelon, E., Godart, N., Épidémiologie de l'anorexie mentale: Revue de la littérature (2013) Encéphale, 39, pp. 85-93
- Russell, G., Bulimia nervosa: An ominous variant of anorexia nervosa (1979) Psychol Med, 9, pp. 429-448
- Takano, A., Shiga, T., Kitagawa, N., Koyama, T., Katoh, C., Tsukamoto, E., Tamaki, N., Abnormal neuronal network in anorexia nervosa studied with I-123-IMP SPECT (2001) Psychiatry Res, 107, pp. 45-50
- Tammela, L.I., Rissanen, A., Kuikka, J.T., Karhunen, L.J., Bergstrom, K.A., Repo-Tiihonen, E., Naukkarinen, H., Uusitupa, M., Treatment improves serotonin transporter binding and reduces binge eating (2003) Psychopharmacology (Berl), 170, pp. 89-93
- Tauscher, J., Pirker, W., Willeit, M., De Zwaan, M., Bailer, U., Neumeister, A., Asenbaum, S., Kasper, S., [123I] beta-CIT and single photon emission computed tomography reveal reduced brain serotonin transporter availability in bulimia nervosa (2001) Biol Psychiatry, 49, pp. 326-332
- Tiihonen, J., Keski-Rahkonen, A., Lopponen, M., Muhonen, M., Kajander, J., Allonen, T., Nagren, K., Rissanen, A., Brain serotonin 1A receptor binding in bulimia nervosa (2004) Biol Psychiatry, 55, pp. 871-873
- Uher, R., Murphy, T., Brammer, M.J., Dalgleish, T., Phillips, M.L., Ng, V.W., Andrew, C.M., Treasure, J., Medial prefrontal cortex activity associated with symptom provocation in eating disorders (2004) Am J Psychiatry, 161, pp. 1238-1246
- van Kuyck, K., Casteels, C., Vermaelen, P., Bormans, G., Nuttin, B., Van Laere, K., Motor- and food-related metabolic cerebral changes in the activity-based rat model for anorexia nervosa: A voxel-based microPET study (2007) Neuroimage, 35, pp. 214-221
- van Kuyck, K., Gerard, N., Van Laere, K., Casteels, C., Pieters, G., Gabriels, L., Nuttin, B., Towards a neurocircuitry in anorexia nervosa: Evidence from functional neuroimaging studies (2009) J Psychiatr Res, 43, pp. 1133-1145
- Wu, J.C., Hagman, J., Buchsbaum, M.S., Blinder, B., Derrfler, M., Tai, W.Y., Hazlett, E., Sicotte, N., Greater left cerebral hemispheric metabolism in bulimia assessed by positron emission tomography (1990) Am J Psychiatry, 147, pp. 309-312
- Yonezawa, H., Otagaki, Y., Miyake, Y., Okamoto, Y., Yamawaki, S., No differences are seen in the regional cerebral blood flow in the restricting type of anorexia nervosa compared with the binge eating/purging type (2008) Psychiatry Clin Neurosci, 62, pp. 26-33
- Yoshizawa, M., Tashiro, M., Fukudo, S., Yanai, K., Utsumi, A., Kano, M., Karahasi, M., Hongo, M., Increased brain histamine H1 receptor binding in patients with anorexia nervosa (2009) Biol Psychiatry, 65, pp. 329-335