Perivascular Innervation in the Nasal Mucosa and Clinical Findings in Patients with Allergic Rhinitis and Idiopathic Rhinitis
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Citações na Scopus
Tipo de produção
article
Data de publicação
2023
Título da Revista
ISSN da Revista
Título do Volume
Editora
GEORG THIEME VERLAG KG
Citação
INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY, v.27, n.4, p.723-732, 2023
Resumo
Introduction The nonspecific hyperreactivity of rhinitis has been attributed to neurotrophins activating sensory nerves and inflammatory cells. The relationship between these markers and the intensity of the symptoms is not well established and few studies have evaluated individuals with idiopathic rhinitis.Objective The present study aims to evaluate whether perivascular innervation and nerve growth factor (NGF) are related to the intensity of the clinical conditions in allergic rhinitis (AR) and idiopathic rhinitis (IR).Methods A total of 15 patients with AR and 15 patients with IR with the indication for inferior turbinectomy (associated or not with septoplasty) were selected. The patients received a score according to their signs and symptoms. After the surgery, we quantified eosinophils, mast cells, NGF, and nerve fibers in the nasal turbinate.Results The score of the signs and symptoms was higher in the AR group. Nerve growth factor was found in the cytoplasm of inflammatory cells in the submucosa in greater quantity in the AR group. The nerve fibers were distributed throughout the tissue, mainly in the subepithelial, glandular, and vascular regions, and there was no difference between the groups. Greater perivascular innervation was associated with a higher signs and symptoms score.Conclusions We concluded that these findings suggest that the NGF produced by submucosal inflammatory cells stimulates increased perivascular innervation in rhinitis, thus directly reflecting in more intense clinical conditions, especially in AR.
Palavras-chave
allergic rhinitis, hyperreactivity, innervation, nerve growth factor, neurotrophins
Referências
- Bernstein JA, 2015, CURR ALLERGY ASTHM R, V15, DOI 10.1007/s11882-015-0511-7
- Bernstein JA, 2011, ANN ALLERG ASTHMA IM, V106, P527, DOI 10.1016/j.anai.2011.02.014
- Bousquet J, 2008, ALLERGY, V63, P8, DOI 10.1111/j.1398-9995.2007.01620.x
- Bresciani M, 2009, ALLERGY, V64, P112, DOI 10.1111/j.1398-9995.2008.01831.x
- Eifan AO, 2016, CLIN EXP ALLERGY, V46, P1139, DOI 10.1111/cea.12780
- Figueroa JM, 1998, AM J RESP CRIT CARE, V157, P1959, DOI 10.1164/ajrccm.157.6.9709019
- Gelardi M, 2008, INT J IMMUNOPATH PH, V21, P325, DOI 10.1177/039463200802100209
- Gelincik A, 2012, ANN ALLERG ASTHMA IM, V108, P396, DOI 10.1016/j.anai.2012.04.006
- Greiwe J, 2016, IMMUNOL ALLERGY CLIN, V36, P289, DOI 10.1016/j.iac.2015.12.006
- Hellings PW, 2017, ALLERGY, V72, P1657, DOI 10.1111/all.13200
- Keh SM, 2008, LARYNGOSCOPE, V118, P573, DOI 10.1097/MLG.0b013e3181625d5a
- Lauria G, 2010, J PERIPHER NERV SYST, V15, P79, DOI 10.1111/j.1529-8027.2010.00269.x
- Mello J F., 2002, Tratado de Otorrinolaringologia. Sociedade Brasileira de Otorrinolaringologia, V68, P87
- Minnone G, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18051028
- Muraro A, 2016, J ALLERGY CLIN IMMUN, V137, P1347, DOI 10.1016/j.jaci.2016.03.010
- Noga O, 2003, CLIN EXP ALLERGY, V33, P649, DOI 10.1046/j.1365-2222.2003.01586.x
- O'Hanlon S, 2007, LARYNGOSCOPE, V117, P1519, DOI 10.1097/MLG.0b013e3180ca7846
- Papadopoulos NG, 2015, ALLERGY, V70, P474, DOI 10.1111/all.12573
- Papadopoulos NG, 2016, IMMUNOL ALLERGY CLIN, V36, P215, DOI 10.1016/j.iac.2015.12.001
- Pfaar O, 2009, SWISS MED WKLY, V139, P35, DOI smw-12468
- Raap U, 2010, CURR OPIN ALLERGY CL, V10, P8, DOI 10.1097/ACI.0b013e328334f5de
- Sakano E., 2017, IV Consenso Brasileiro sobre Rinites Documento conjunto da Associacao Brasileira de Alergia e Imunologia, ABORL-CCF e SBP, P1
- Segboer CL, 2013, ALLERGY, V68, P1427, DOI 10.1111/all.12255
- Wise SK, 2018, INT FORUM ALLERGY RH, V8, P85, DOI [10.1002/alr.22070, 10.1002/alr.22073]
- Yum HY, 2021, CLIN EXP PEDIATR, V64, P373, DOI 10.3345/cep.2020.00822