Neurovascular and hemodynamic responses to mental stress and exercise in severe COVID-19 survivors

Nenhuma Miniatura disponível
Citações na Scopus
3
Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
AMER PHYSIOLOGICAL SOC
Autores
FARIA, Diego
MOLL-BERNARDES, Renata
TESTA, Laura
MONIZ, Camila M. V.
RODRIGUES, Erika C.
MOTA, Jose M.
ONO, Bruna E.
IZAIAS, Joao E.
Citação
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v.325, n.3, p.R269-R279, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Previous studies show that COVID-19 survivors have elevated muscle sympathetic nerve activity (MSNA), endothelial dysfunction, and aortic stiffening. However, the neurovascular responses to mental stress and exercise are still unexplored. We hypothesized that COVID-19 survivors, compared with age-and body mass index (BMI)-matched control subjects, exhibit abnormal neurovascular responses to mental stress and physical exercise. Fifteen severe COVID-19 survivors (aged: 49 +/- 2 yr, BMI: 30 +/- 1 kg/m(2)) and 15 well-matched control subjects (aged: 46 +/- 3 yr, BMI: 29 +/- 1 kg/m(2)) were studied. MSNA (microneurography), forearm blood flow (FBF), and forearm vascular conductance (FVC, venous occlusion plethysmography), mean arterial pressure (MAP, Finometer), and heart rate (HR, ECG) were measured during a 3-min mental stress (Stroop Color-Word Test) and during a 3-min isometric handgrip exercise (30% of maximal voluntary contraction). During mental stress, MSNA (frequency and incidence) responses were higher in COVID-19 survivors than in controls (P < 0.001), and FBF and FVC responses were attenuated (P < 0.05). MAP was similar between the groups (P > 0.05). In contrast, the MSNA (frequency and incidence) and FBF and FVC responses to handgrip exercise were similar between the groups (P > 0.05). MAP was lower in COVID-19 survivors (P < 0.05). COVID-19 survivors exhibit an exaggerated MSNA and blunted vasodilatory response to mental challenge compared with healthy adults. However, the neurovascular response to handgrip exercise is preserved in COVID-19 survivors. Overall, the abnormal neurovascular control in response to mental stress suggests that COVID-19 survivors may have an increased risk to cardiovascular events during mental challenge.
Palavras-chave
exercise, mental stress, peripheral blood flow, sympathetic activity, vascular conductance
URI
https://observatorio.fm.usp.br/handle/OPI/57893
Referências
  1. Agrawal S, 2022, ACTA NEUROPATHOL COM, V10, DOI 10.1186/s40478-022-01493-7
  2. Baratto C, 2021, J APPL PHYSIOL, V130, P1470, DOI 10.1152/japplphysiol.00710.2020
  3. Bogert LWJ, 2005, EXP PHYSIOL, V90, P437, DOI 10.1113/expphysiol.2005.030262
  4. Bowe B, 2022, NAT MED, V28, P2398, DOI 10.1038/s41591-022-02051-3
  5. Cardillo C, 1997, AM J CARDIOL, V80, P1070, DOI 10.1016/S0002-9149(97)00605-X
  6. Carter JR, 2015, COMPR PHYSIOL, V5, P119, DOI 10.1002/cphy.c140030
  7. Carter JR, 2009, AM J PHYSIOL-HEART C, V296, pH847, DOI 10.1152/ajpheart.01234.2008
  8. Carter JR, 2005, J PHYSIOL-LONDON, V564, P321, DOI 10.1113/jphysiol.2004.079665
  9. Chida Y, 2010, HYPERTENSION, V55, P1026, DOI 10.1161/HYPERTENSIONAHA.109.146621
  10. Esler M, 2003, ACTA PHYSIOL SCAND, V177, P275, DOI 10.1046/j.1365-201X.2003.01089.x
  11. Esler M, 2008, ANN NY ACAD SCI, V1148, P338, DOI 10.1196/annals.1410.064
  12. Faria D, 2023, HYPERTENSION, V80, P470, DOI 10.1161/HYPERTENSIONAHA.122.19958
  13. Fonkoue IT, 2016, AM J PHYSIOL-HEART C, V311, pH426, DOI 10.1152/ajpheart.00378.2016
  14. Fonkoue IT, 2015, AM J PHYSIOL-REG I, V309, pR1380, DOI 10.1152/ajpregu.00344.2015
  15. HAJDUCZOK G, 1991, CIRC RES, V69, P66, DOI 10.1161/01.RES.69.1.66
  16. Halliwill JR, 1997, J PHYSIOL-LONDON, V504, P211, DOI 10.1111/j.1469-7793.1997.211bf.x
  17. Lambert G, 2010, HYPERTENSION, V55, pE20, DOI 10.1161/HYPERTENSIONAHA.110.153841
  18. Macefield VG, 2013, INT J PSYCHOPHYSIOL, V89, P451, DOI 10.1016/j.ijpsycho.2013.06.002
  19. Middlekauff HR, 1997, CIRCULATION, V96, P1835, DOI 10.1161/01.CIR.96.6.1835
  20. Padilla J, 2011, PHYSIOLOGY, V26, P132, DOI 10.1152/physiol.00052.2010
  21. Ratchford SM, 2021, AM J PHYSIOL-HEART C, V320, pH404, DOI 10.1152/ajpheart.00897.2020
  22. Sales ARK, 2014, AM J PHYSIOL-HEART C, V306, pH963, DOI 10.1152/ajpheart.00811.2013
  23. Sales ARK, Am J Physiol Heart Circ Physiol
  24. Santos AC, 2005, AM J PHYSIOL-HEART C, V289, pH593, DOI 10.1152/ajpheart.01240.2004
  25. Sarkar S, 2023, MEDCOMM, V4, DOI 10.1002/mco2.247
  26. Satterfield BA, 2022, NAT REV CARDIOL, V19, P332, DOI 10.1038/s41569-021-00631-3
  27. Smith SA, 2006, EXP PHYSIOL, V91, P89, DOI 10.1113/expphysiol.2005.032367
  28. Stute NL, 2021, J PHYSIOL-LONDON, V599, P4269, DOI 10.1113/JP281888
  29. Szekely Y, 2021, J AM SOC ECHOCARDIOG, V34, P1273, DOI 10.1016/j.echo.2021.08.022
  30. Teixeira AL, 2022, CLIN AUTON RES, V32, P271, DOI 10.1007/s10286-022-00872-3
  31. Thomas GD, 2015, AUTON NEUROSCI-BASIC, V188, P64, DOI 10.1016/j.autneu.2014.10.019
  32. VICTOR RG, 1987, J CLIN INVEST, V79, P508, DOI 10.1172/JCI112841
  33. Wang WJ, 2022, ECLINICALMEDICINE, V53, DOI 10.1016/j.eclinm.2022.101619
  34. Xie Y, 2023, JAMA-J AM MED ASSOC, V329, P1697, DOI 10.1001/jama.2023.5348
  35. Xie Y, 2022, NAT MED, V28, P583, DOI 10.1038/s41591-022-01689-3
  36. Yang H, 2013, AM J PHYSIOL-HEART C, V304, pH436, DOI 10.1152/ajpheart.00688.2012

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - COVID-19
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/05
Artigos e Materiais de Revistas Científicas - LIM/11
Artigos e Materiais de Revistas Científicas - LIM/59
Carregar mais