Biomarkers in bladder pain syndrome: A new narrative
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2021
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de Magalhaes, T. F.; Haddad, J.. Biomarkers in bladder pain syndrome: A new narrative. In: . FEATURES AND ASSESSMENTS OF PAIN, ANESTHESIA, AND ANALGESIA: ELSEVIER, 2021. p.527-538.
Resumo
Bladder pain syndrome, or interstitial cystitis (IC/BPS), is chronic pain disorder of unknown etiology that negatively affects quality of life. Its definition has changed several times in the past 40years and is not homogeneous throughout guidelines. Proposed pathophysiologic mechanisms for IC/BPS include central neurologic changes, inflammation, urothelial dysfunction, autoimmunity, and infection, among others. In order to aid in disease diagnosis and follow-up, researchers have engaged in discovering biomarkers for this disease. Potential biomarkers for IC/BPS found in the bladder wall, urine, serum, and stool have been reported, but none has proven to be clinically useful so far. In this chapter, biomarkers are explored in relation to possible clinical applications and role in disease pathomechanisms. In order for reports to be comparable and for us to progress in determining useful biomarkers for this disease, the definition of IC/BPS should be standardized. © 2022 Elsevier Inc. All rights reserved.
Palavras-chave
Biomarkers, Bladder dysfunction, Bladder pain syndrome, Interstitial cystitis, Pathophysiology
Referências
- Abernethy, M.G., Rosenfeld, A., White, J.R., Mueller, M.G., Lewicky-Gaupp, C., Kenton, K., Urinary microbiome and cytokine levels in women with interstitial cystitis (2017) Obstetrics and Gynecology, 129 (3), pp. 500-506
- Abrams, P., Cardozo, L., Fall, M., Griffiths, D., Rosier, P., Ulmsten, U., Wein, A., The standardisation of terminology of lower urinary tract function: Report from the standardisation sub-committee of the international continence society (2002) American Journal of Obstetrics and Gynecology, 187 (1), pp. 116-126
- Bradley, M.S., Burke, E.E., Grenier, C., Amundsen, C.L., Murphy, S.K., Siddiqui, N.Y., A genome-scale DNA methylation study in women with interstitial cystitis/bladder pain syndrome (2018) Neurourology and Urodynamics, 37 (4), pp. 1485-1493
- Braundmeier-Fleming, A., Russell, N.T., Yang, W., Nas, M.Y., Yaggie, R.E., Berry, M., Klumpp, D.J., Stool-based biomarkers of interstitial cystitis/bladder pain syndrome (2016) Scientific Reports, 6, p. 26083
- Buzzega, D., Maccari, F., Galeotti, F., Volpi, N., Determination of urinary hexosamines for diagnosis of bladder pain syndrome (2012) International Urogynecology Journal, 23 (10), pp. 1367-1372
- Byrne, D.S., Sedor, J.F., Estojak, J., Fitzpatrick, K.J., Chiura, A.N., Mulholland, S.G., The urinary glycoprotein GP51 as a clinical marker for interstitial cystitis (1999) The Journal of Urology, 161 (6), pp. 1786-1790
- Chai, T.C., Zhang, C.O., Shoenfelt, J.L., Johnson, H.W., Jr., Warren, J.W., Keay, S., Bladder stretch alters urinary heparin-binding epidermal growth factor and antiproliferative factor in patients with interstitial cystitis (2000) The Journal of Urology, 163 (5), pp. 1440-1444
- Choi, D., Han, J.Y., Shin, J.H., Ryu, C.M., Yu, H.Y., Kim, A., Choo, M.S., Downregulation of WNT11 is associated with bladder tissue fibrosis in patients with interstitial cystitis/bladder pain syndrome without Hunner lesion (2018) Scientific Reports, 8 (1)
- Chung, S.D., Liu, H.T., Lin, H., Kuo, H.C., Elevation of serum c-reactive protein in patients with OAB and IC/BPS implies chronic inflammation in the urinary bladder (2011) Neurourology and Urodynamics, 30 (3), pp. 417-420
- Coelho, A., Oliveira, R., Antunes-Lopes, T., Cruz, C.D., Partners in crime: NGF and BDNF in visceral dysfunction (2019) Current Neuropharmacology, 17 (11), pp. 1021-1038
- Corcoran, A.T., Yoshimura, N., Tyagi, V., Jacobs, B., Leng, W., Tyagi, P., Mapping the cytokine profile of painful bladder syndrome/interstitial cystitis in human bladder and urine specimens (2013) World Journal of Urology, 31 (1), pp. 241-246
- Duh, K., Funaro, M.G., DeGouveia, W., Bahlani, S., Pappas, D., Najjar, S., Stern, J.N.H., Crosstalk between the immune system and neural pathways in interstitial cystitis/bladder pain syndrome (2018) Discovery Medicine, 25 (139), pp. 243-250
- El-Mansoury, M., Boucher, W., Sant, G.R., Theoharides, T.C., Increased urine histamine and methylhistamine in interstitial cystitis (1994) The Journal of Urology, 152 (2), pp. 350-353
- Erickson, D.R., Xie, S.X., Bhavanandan, V.P., Wheeler, M.A., Hurst, R.E., Demers, L.M., Keay, S.K., A comparison of multiple urine markers for interstitial cystitis (2002) The Journal of Urology, 167 (6), pp. 2461-2469
- Evans, R.J., Moldwin, R.M., Cossons, N., Darekar, A., Mills, I.W., Scholfield, D., Proof of concept trial of tanezumab for the treatment of symptoms associated with interstitial cystitis (2011) The Journal of Urology, 185 (5), pp. 1716-1721
- Felsen, D., Frye, S., Trimble, L.A., Bavendam, T.G., Parsons, C.L., Sim, Y., Vaughan, E.D., Jr., Inflammatory mediator profile in urine and bladder wash fluid of patients with interstitial cystitis (1994) The Journal of Urology, 152 (2), pp. 355-361
- Gamper, M., Viereck, V., Eberhard, J., Binder, J., Moll, C., Welter, J., Moser, R., Local immune response in bladder pain syndrome/interstitial cystitis ESSIC type 3C (2013) International Urogynecology Journal, 24 (12), pp. 2049-2057
- Goo, Y.A., Tsai, Y.S., Liu, A.Y., Goodlett, D.R., Yang, C.C., Urinary proteomics evaluation in interstitial cystitis/painful bladder syndrome: A pilot study (2010) International Brazilian Journal of Urology, 36 (4), pp. 464-478. , discussion 478-469, 479
- Grover, S., Srivastava, A., Lee, R., Tewari, A.K., Te, A.E., Role of inflammation in bladder function and interstitial cystitis (2011) Therapeutic Advances in Urology, 3 (1), pp. 19-33
- Hanno, P.M., Interstitial cystitis-epidemiology, diagnostic criteria, clinical markers (2002) Revista de Urología, 1, pp. S3-S8. , 4 Suppl
- Hanno, P.M., Erickson, D., Moldwin, R., Faraday, M.M., Diagnosis and treatment of interstitial cystitis/bladder pain syndrome: AUA guideline amendment (2015) The Journal of Urology, 193 (5), pp. 1545-1553
- Hauser, P.J., Dozmorov, M.G., Bane, B.L., Slobodov, G., Culkin, D.J., Hurst, R.E., Abnormal expression of differentiation related proteins and proteoglycan core proteins in the urothelium of patients with interstitial cystitis (2008) The Journal of Urology, 179 (2), pp. 764-769
- Homma, Y., Nomiya, A., Tagaya, M., Oyama, T., Takagaki, K., Nishimatsu, H., Igawa, Y., Increased mRNA expression of genes involved in pronociceptive inflammatory reactions in bladder tissue of interstitial cystitis (2013) The Journal of Urology, 190 (5), pp. 1925-1931
- Hurst, R.E., Roy, J.B., Min, K.W., Veltri, R.W., Marley, G., Patton, K., Parsons, C.L., A deficit of chondroitin sulfate proteoglycans on the bladder uroepithelium in interstitial cystitis (1996) Urology, 48 (5), pp. 817-821
- Jiang, Y.H., Peng, C.H., Liu, H.T., Kuo, H.C., Increased pro-inflammatory cytokines, C-reactive protein and nerve growth factor expressions in serum of patients with interstitial cystitis/bladder pain syndrome (2013) PLoS One, 8 (10). , e76779
- Keay, S., Kleinberg, M., Zhang, C.O., Hise, M.K., Warren, J.W., Bladder epithelial cells from patients with interstitial cystitis produce an inhibitor of heparin-binding epidermal growth factor-like growth factor production (2000) The Journal of Urology, 164 (6), pp. 2112-2118
- Keay, S., Zhang, C.O., Kagen, D.I., Hise, M.K., Jacobs, S.C., Hebel, J.R., Warren, J.W., Concentrations of specific epithelial growth factors in the urine of interstitial cystitis patients and controls (1997) The Journal of Urology, 158 (5), pp. 1983-1988
- Keay, S.K., Zhang, C.O., Shoenfelt, J., Erickson, D.R., Whitmore, K., Warren, J.W., Chai, T., Sensitivity and specificity of antiproliferative factor, heparin-binding epidermal growth factor-like growth factor, and epidermal growth factor as urine markers for interstitial cystitis (2001) Urology, 57 (6), pp. 9-14
- Kiuchi, H., Tsujimura, A., Takao, T., Yamamoto, K., Nakayama, J., Miyagawa, Y., Okuyama, A., Increased vascular endothelial growth factor expression in patients with bladder pain syndrome/interstitial cystitis: Its association with pain severity and glomerulations (2009) BJU International, 104 (6), pp. 826-831. , (discussion 831)
- Kuo, H.C., Liu, H.T., Tyagi, P., Chancellor, M.B., Urinary nerve growth factor levels in urinary tract diseases with or without frequency urgency symptoms (2010) Low Urinary Tract Symptoms, 2 (2), pp. 88-94
- Lamale, L.M., Lutgendorf, S.K., Zimmerman, M.B., Kreder, K.J., Interleukin-6, histamine, and methylhistamine as diagnostic markers for interstitial cystitis (2006) Urology, 68 (4), pp. 702-706
- Lee, C.L., Jiang, Y.H., Kuo, H.C., Increased apoptosis and suburothelial inflammation in patients with ketamine-related cystitis: A comparison with non-ulcerative interstitial cystitis and controls (2013) BJU International, 112 (8), pp. 1156-1162
- Lee, J.D., Lee, M.H., Increased expression of hypoxia-inducible factor-1α and vascular endothelial growth factor associated with glomerulation formation in patients with interstitial cystitis (2011) Urology, 78 (4). , 971.e11-5
- Liu, H.T., Kuo, H.C., Increased urine and serum nerve growth factor levels in interstitial cystitis suggest chronic inflammation is involved in the pathogenesis of disease (2012) PLoS One, 7 (9). , e44687
- Liu, H.T., Shie, J.H., Chen, S.H., Wang, Y.S., Kuo, H.C., Differences in mast cell infiltration, E-cadherin, and zonula occludens-1 expression between patients with overactive bladder and interstitial cystitis/bladder pain syndrome (2012) Urology, 80 (1). , 225.e213-8
- Liu, H.T., Tyagi, P., Chancellor, M.B., Kuo, H.C., Urinary nerve growth factor level is increased in patients with interstitial cystitis/bladder pain syndrome and decreased in responders to treatment (2009) BJU International, 104 (10), pp. 1476-1481
- Liu, H.T., Tyagi, P., Chancellor, M.B., Kuo, H.C., Urinary nerve growth factor but not prostaglandin E2 increases in patients with interstitial cystitis/bladder pain syndrome and detrusor overactivity (2010) BJU International, 106 (11), pp. 1681-1685
- Lokeshwar, V.B., Selzer, M.G., Cerwinka, W.H., Gomez, M.F., Kester, R.R., Bejany, D.E., Gousse, A.E., Urinary uronate and sulfated glycosaminoglycan levels: Markers for interstitial cystitis severity (2005) The Journal of Urology, 174 (1), pp. 344-349
- Lotz, M., Villiger, P., Hugli, T., Koziol, J., Zuraw, B.L., Interleukin-6 and interstitial cystitis (1994) The Journal of Urology, 152 (3), pp. 869-873
- Lowe, E.M., Anand, P., Terenghi, G., Williams-Chestnut, R.E., Sinicropi, D.V., Osborne, J.L., Increased nerve growth factor levels in the urinary bladder of women with idiopathic sensory urgency and interstitial cystitis (1997) British Journal of Urology, 79 (4), pp. 572-577
- Magalhaes, T.F., Baracat, E.C., Doumouchtsis, S.K., Haddad, J.M., Biomarkers in the diagnosis and symptom assessment of patients with bladder pain syndrome: A systematic review (2019) International Urogynecology Journal, 30 (11), pp. 1785-1794
- Makino, T., Kawashima, H., Konishi, H., Nakatani, T., Kiyama, H., Elevated urinary levels and urothelial expression of hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein in patients with interstitial cystitis (2010) Urology, 75 (4), pp. 933-937
- Marcu, I., Campian, E.C., Tu, F.F., Interstitial cystitis/bladder pain syndrome (2018) Seminars in Reproductive Medicine, 36 (2), pp. 123-135
- Ogawa, T., Homma, T., Igawa, Y., Seki, S., Ishizuka, O., Imamura, T., Nishizawa, O., CXCR3 binding chemokine and TNFSF14 over expression in bladder urothelium of patients with ulcerative interstitial cystitis (2010) The Journal of Urology, 183 (3), pp. 1206-1212
- Pape, J., Falconi, G., De Mattos Lourenco, T.R., Doumouchtsis, S.K., Betschart, C., Variations in bladder pain syndrome/interstitial cystitis (IC) definitions, pathogenesis, diagnostics and treatment: A systematic review and evaluation of national and international guidelines (2019) International Urogynecology Journal, 30 (11), pp. 1795-1805
- Parker, K.S., Crowley, J.R., Stephens-Shields, A.J., van Bokhoven, A., Lucia, M.S., Lai, H.H., Henderson, J.P., Urinary metabolomics identifies a molecular correlate of interstitial cystitis/bladder pain syndrome in a multidisciplinary approach to the study of chronic pelvic pain (MAPP) research network cohort (2016) eBioMedicine, 7, pp. 167-174
- Patnaik, S.S., Lagana, A.S., Vitale, S.G., Buttice, S., Noventa, M., Gizzo, S., Dandolu, V., Etiology, pathophysiology and biomarkers of interstitial cystitis/painful bladder syndrome (2017) Archives of Gynecology and Obstetrics, 295 (6), pp. 1341-1359
- Peeker, R., Enerbäck, L., Fall, M., Aldenborg, F., Recruitment, distribution and phenotypes of mast cells in interstitial cystitis (2000) The Journal of Urology, 163 (3), pp. 1009-1015
- Peng, C.H., Jhang, J.F., Shie, J.H., Kuo, H.C., Down regulation of vascular endothelial growth factor is associated with decreased inflammation after intravesical OnabotulinumtoxinA injections combined with hydrodistention for patients with interstitial cystitis- -clinical results and immunohistochemistry analysis (2013) Urology, 82 (6). , 1452.e1451-6
- Peters, K.M., Diokno, A.C., Steinert, B.W., Preliminary study on urinary cytokine levels in interstitial cystitis: Does intravesical bacille Calmette-Guérin treat interstitial cystitis by altering the immune profile in the bladder? (1999) Urology, 54 (3), pp. 450-453
- Rofeim, O., Shupp-Byrne, D., Mulholland, G.S., Moldwin, R.M., The effects of hydrodistention on bladder surface mucin (2001) Urology, 57 (6), p. 130
- Shahid, M., Gull, N., Yeon, A., Cho, E., Bae, J., Yoon, H.S., Kim, J., Alpha-oxoglutarate inhibits the proliferation of immortalized normal bladder epithelial cells via an epigenetic switch involving ARID1A (2018) Scientific Reports, 8 (1), p. 4505
- Shie, J.H., Kuo, H.C., Higher levels of cell apoptosis and abnormal E-cadherin expression in the urothelium are associated with inflammation in patients with interstitial cystitis/painful bladder syndrome (2011) BJU International, 108 (2), pp. E136-E141
- Slobodov, G., Feloney, M., Gran, C., Kyker, K.D., Hurst, R.E., Culkin, D.J., Abnormal expression of molecular markers for bladder impermeability and differentiation in the urothelium of patients with interstitial cystitis (2004) The Journal of Urology, 171 (4), pp. 1554-1558
- Tamaki, M., Saito, R., Ogawa, O., Yoshimura, N., Ueda, T., Possible mechanisms inducing glomerulations in interstitial cystitis: Relationship between endoscopic findings and expression of angiogenic growth factors (2004) The Journal of Urology, 172 (3), pp. 945-948
- Tonyali, S., Ates, D., Akbiyik, F., Kankaya, D., Baydar, D., Ergen, A., Urine nerve growth factor (NGF) level, bladder nerve staining and symptom/problem scores in patients with interstitial cystitis (2018) Advances in Clinical and Experimental Medicine, 27 (2), pp. 159-163
- Tseng-Rogenski, S., Liebert, M., Interleukin-8 is essential for normal urothelial cell survival (2009) American Journal of Physiology. Renal Physiology, 297 (3), pp. F816-F821
- Tyagi, P., Killinger, K., Tyagi, V., Nirmal, J., Chancellor, M., Peters, K.M., Urinary chemokines as noninvasive predictors of ulcerative interstitial cystitis (2012) The Journal of Urology, 187 (6), pp. 2243-2248
- van de Merwe, J.P., Nordling, J., Bouchelouche, P., Bouchelouche, K., Cervigni, M., Daha, L.K., Wyndaele, J.J., Diagnostic criteria, classification, and nomenclature for painful bladder syndrome/interstitial cystitis: An ESSIC proposal (2008) European Urology, 53 (1), pp. 60-67
- Van der Aa, F., Beckley, I., de Ridder, D., Polyomavirus BK—a potential new therapeutic target for painful bladder syndrome/interstitial cystitis? (2014) Medical Hypotheses, 83 (3), pp. 317-320
- Vera, P.L., Preston, D.M., Moldwin, R.M., Erickson, D.R., Mowlazadeh, B., Ma, F., Fall, M., Elevated urine levels of macrophage migration inhibitory factor in inflammatory bladder conditions: A potential biomarker for a subgroup of interstitial cystitis/bladder pain syndrome patients (2018) Urology, 116, pp. 55-62
- Wada, N., Ameda, K., Furuno, T., Okada, H., Date, I., Kakizaki, H., Evaluation of prostaglandin E2 and E-series prostaglandin receptor in patients with interstitial cystitis (2015) The Journal of Urology, 193 (6), pp. 1987-1993
- Wen, H., Lee, T., You, S., Park, S.H., Song, H., Eilber, K.S., Kim, J., Urinary metabolite profiling combined with computational analysis predicts interstitial cystitis-associated candidate biomarkers (2015) Journal of Proteome Research, 14 (1), pp. 541-548
- Zeng, Y., Wu, X.X., Homma, Y., Yoshimura, N., Iwaki, H., Kageyama, S., Kakehi, Y., Uroplakin III-delta4 messenger RNA as a promising marker to identify nonulcerative interstitial cystitis (2007) The Journal of Urology, 178 (4), pp. 1322-1327. , (discussion 1327)
- Zhang, C.O., Li, Z.L., Kong, C.Z., APF, HB-EGF, and EGF biomarkers in patients with ulcerative vs. non-ulcerative interstitial cystitis (2005) BMC Urology, 5, p. 7
- Zhang, C.O., Li, Z.L., Shoenfelt, J.L., Kong, C.Z., Chai, T.C., Erickson, D.R., Keay, S., Comparison of APF activity and epithelial growth factor levels in urine from Chinese, African-American, and white American patients with interstitial cystitis (2003) Urology, 61 (5), pp. 897-901