Influence of exposure to climate-related hazards in the phenotypic expression of primary Sjögren's syndrome

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorFLORES-CHAVEZ, A.
dc.contributor.authorBRITO-ZERON, P.
dc.contributor.authorNG, W. -f.
dc.contributor.authorSZANTO, A.
dc.contributor.authorRASMUSSEN, A.
dc.contributor.authorPRIORI, R.
dc.contributor.authorBALDINI, C.
dc.contributor.authorARMAGAN, B.
dc.contributor.authorOEZKIZILTAS, B.
dc.contributor.authorPRAPROTNIK, S.
dc.contributor.authorSUZUKI, Y.
dc.contributor.authorQUARTUCCIO, L.
dc.contributor.authorHERNANDEZ-MOLINA, G.
dc.contributor.authorINANC, N.
dc.contributor.authorBARTOLONI, E.
dc.contributor.authorRISCHMUELLER, M.
dc.contributor.authorOLIVEIRA, F. Reis-de
dc.contributor.authorTREVISANI, V. Fernandes Moca
dc.contributor.authorJURCUT, C.
dc.contributor.authorNORDMARK, G.
dc.contributor.authorCARUBBI, F.
dc.contributor.authorHOFAUER, B.
dc.contributor.authorVALIM, V.
dc.contributor.authorPASOTO, S. G.
dc.contributor.authorRETAMOZO, S.
dc.contributor.authorATZENI, F.
dc.contributor.authorFONSECA-AIZPURU, E.
dc.contributor.authorLOPEZ-DUPLA, M.
dc.contributor.authorGIACOMELLI, R.
dc.contributor.authorNAKAMURA, H.
dc.contributor.authorAKASBI, M.
dc.contributor.authorTHOMPSON, K.
dc.contributor.authorHORVATH, I. Fanny
dc.contributor.authorFARRIS, A. D.
dc.contributor.authorSIMONCELLI, E.
dc.contributor.authorBOMBARDIERI, S.
dc.contributor.authorKILIC, L.
dc.contributor.authorTUFAN, A.
dc.contributor.authorPIRKMAJER, K. Perdan
dc.contributor.authorFUJISAWA, Y.
dc.contributor.authorVITA, S. De
dc.contributor.authorABACAR, K.
dc.contributor.authorRAMOS-CASALS, M.
dc.contributor.groupauthor, SBDC
dc.date.accessioned2024-02-15T14:55:42Z
dc.date.available2024-02-15T14:55:42Z
dc.date.issued2023
dc.description.abstractObjective To analyse how the key components at the time of diagnosis of the Sjogren's phenotype (epidemiological profile, sicca symptoms, and systemic disease) can be influenced by the potential exposure to climate-related natural hazards. Methods For the present study, the following variables were selected for harmonisation and refinement: age, sex, country, fulfilment of 2002/2016 criteria items, dry eyes, dry mouth, and overall ESSDAI score. Climate-related hazards per country were defined according to the OECD and included seven climate-related hazard types: extreme temperature, extreme precipitation, drought, wildfire, wind threats, river flooding, and coastal flooding. Climatic variables were defined as dichotomous variables according to whether each country is ranked among the ten countries with the most significant exposure. Results After applying data-cleaning techniques and excluding people from countries not included in the OECD climate rankings, the database study analysed 16,042 patients from 23 countries. The disease was diagnosed between 1 and 3 years earlier in people living in countries included among the top 10 worst exposed to extreme precipitation, wildfire, wind threats, river flooding, and coastal flooding. A lower frequency of dry eyes was observed in people living in countries exposed to wind threats, river flooding, and coastal flooding, with a level of statistical association being classified as strong (p<0.0001 for the three variables). The frequency of dry mouth was significantly lower in people living in countries exposed to river flooding (p<0.0001) and coastal flooding (p<0.0001). People living in countries included in the worse climate scenarios for extreme temperature (p<0.0001) and river flooding (p<0.0001) showed a higher mean ESSDAI score in comparison with people living in no-risk countries. In contrast, those living in countries exposed to worse climate scenarios for wind threats (p<0.0001) and coastal flooding (p<0.0001) showed a lower mean ESSDAI score in comparison with people living in no-risk countries. Conclusion Local exposure to extreme climate-related hazards plays a role in modulating the presentation of Sjogren across countries concerning the age at which the disease is diagnosed, the frequency of dryness, and the degree of systemic activity.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.identifier.citationCLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v.41, n.12, p.2437-2447, 2023
dc.identifier.doi10.55563/clinexprheumatol/pmbay6
dc.identifier.eissn1593-098X
dc.identifier.issn0392-856X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/58194
dc.language.isoeng
dc.publisherCLINICAL & EXPER RHEUMATOLOGYeng
dc.relation.ispartofClinical and Experimental Rheumatology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright CLINICAL & EXPER RHEUMATOLOGYeng
dc.subjectSjogren's syndromeeng
dc.subjectdrynesseng
dc.subjectsystemiceng
dc.subjectESSDAIeng
dc.subjectclimateeng
dc.subjectepidemiologyeng
dc.subject.othersjogrens-syndromeeng
dc.subject.otherseasonalityeng
dc.subject.wosRheumatologyeng
dc.titleInfluence of exposure to climate-related hazards in the phenotypic expression of primary Sjögren's syndromeeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEspanha
hcfmusp.affiliation.countryInglaterra
hcfmusp.affiliation.countryHungria
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryItália
hcfmusp.affiliation.countryTurquia
hcfmusp.affiliation.countryEslovênia
hcfmusp.affiliation.countryJapão
hcfmusp.affiliation.countryMéxico
hcfmusp.affiliation.countryAustrália
hcfmusp.affiliation.countryRomênia
hcfmusp.affiliation.countrySuécia
hcfmusp.affiliation.countryAlemanha
hcfmusp.affiliation.countryisoes
hcfmusp.affiliation.countryisogb
hcfmusp.affiliation.countryisohu
hcfmusp.affiliation.countryisous
hcfmusp.affiliation.countryisoit
hcfmusp.affiliation.countryisotr
hcfmusp.affiliation.countryisosi
hcfmusp.affiliation.countryisojp
hcfmusp.affiliation.countryisomx
hcfmusp.affiliation.countryisoau
hcfmusp.affiliation.countryisoro
hcfmusp.affiliation.countryisose
hcfmusp.affiliation.countryisode
hcfmusp.author.externalFLORES-CHAVEZ, A.:Hosp Clin Barcelona, Dept Autoimmune Dis, ICMiD, Barcelona, Spain
hcfmusp.author.externalBRITO-ZERON, P.:Sanitas Digital Hosp, Hosp CIMA Ctr Med Milenium Balmes Sanitas, Autoimmune Dis Unit, Res & Innovat Grp Autoimmune Dis, Barcelona, Spain
hcfmusp.author.externalNG, W. -f.:Newcastle Univ, Translat & Clin Res Inst, Newcastle Upon Tyne, Northumberland, England; Newcastle Tyne Hosp NHS Fdn Trust, NIHR Newcastle Biomed Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England
hcfmusp.author.externalSZANTO, A.:Univ Debrecen, Fac Med, Div Rheumatol, Debrecen, Hungary
hcfmusp.author.externalRASMUSSEN, A.:Oklahoma Med Res Fdn, Genes & Human Dis Res Program, Oklahoma City, OK USA
hcfmusp.author.externalPRIORI, R.:Sapienza Univ, Dept Internal Med & Med Specialties, Rome, Italy; St Camillus Int Univ Hlth Sci, UniCamillus, Rome, Italy
hcfmusp.author.externalBALDINI, C.:Univ Pisa, Rheumatol Unit, Pisa, Italy
hcfmusp.author.externalARMAGAN, B.:Hacettepe Univ, Fac Med, Dept Internal Med, Div Rheumatol, Ankara, Turkey
hcfmusp.author.externalOEZKIZILTAS, B.:Gazi Univ, Sch Med, Dept Internal Med, Div Rheumatol, Ankara, Turkey
hcfmusp.author.externalPRAPROTNIK, S.:Univ Med Ctr Ljubljana, Dept Rheumatol, Llubljana, Slovenia
hcfmusp.author.externalSUZUKI, Y.:Kanazawa Univ Hosp, Div Rheumatol, Kanazawa, Ishikawa, Japan
hcfmusp.author.externalQUARTUCCIO, L.:St Maria Misericordia Univ Hosp, Univ Udine, Inst Dermatol, Dept Expt & Clin Med, Piazzale St Maria Misericordia 15, I-33100 Udine, Italy
hcfmusp.author.externalHERNANDEZ-MOLINA, G.:Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Immunol & Rheumatol, Mexico City, Mexico
hcfmusp.author.externalINANC, N.:Marmara Univ, Sch Med, Istanbul, Turkey
hcfmusp.author.externalBARTOLONI, E.:Univ Perugia, Dept Med, Rheumatol Unit, Perugia, Italy
hcfmusp.author.externalRISCHMUELLER, M.:Univ Adelaide, Queen Elizabeth Hosp, Discipline Med, Woodville, SA 5011, Australia
hcfmusp.author.externalOLIVEIRA, F. Reis-de:Univ Sao Paulo, Dept Ribeirao Preto Med Sch, Ribeirao Preto, Brazil
hcfmusp.author.externalTREVISANI, V. Fernandes Moca:Univ Fed Sao Paulo, Evidence Based Hlth Postgrad Program, Sao Paulo, Brazil
hcfmusp.author.externalJURCUT, C.:Dr Carol Davila Cent Mil Emergency Univ Hosp, Dept Gastroenterol & Internal Med, Bucharest, Romania
hcfmusp.author.externalNORDMARK, G.:Uppsala Univ, Dept Med Sci, Rheumatol, Uppsala, Sweden
hcfmusp.author.externalCARUBBI, F.:San Salvatore Hosp, Internal Med & Nephrol Unit, Laquila, Italy
hcfmusp.author.externalHOFAUER, B.:Tech Univ Munich, Dept Otorhinolaryngol Head & Neck Surg, Munich, Germany
hcfmusp.author.externalVALIM, V.:Univ Fed Espirito Santo HUCAM UFES EBSERH, Hosp Univ Cassiano Antonio Moraes, Vitoria, ES, Brazil
hcfmusp.author.externalRETAMOZO, S.:Quiron Salud Hosp, Badajoz, Spain
hcfmusp.author.externalATZENI, F.:Univ Messina, Rheumatol Unit, Messina, Italy
hcfmusp.author.externalFONSECA-AIZPURU, E.:Hosp Cabuenes, Serv Med EMULSA, Gijon, Spain
hcfmusp.author.externalLOPEZ-DUPLA, M.:Fdn Policlin Univ, Campus Biomed Roma, Rome, Italy
hcfmusp.author.externalGIACOMELLI, R.:Hosp Univ Joan XXIII, Dept Internal Med, Tarragona 43007, Spain; Univ Campus Biomed Roma, Dept Med & Surg, Res Unit Neurol, Rome, Italy
hcfmusp.author.externalNAKAMURA, H.:Nihon Univ, Sch Med, Dept Med, Div Hematol & Rheumatol,Itabashi Ku, Tokyo, Japan
hcfmusp.author.externalAKASBI, M.:Univ Hosp Infanta Leonor, Dept Internal Med, Madrid, Spain
hcfmusp.author.externalTHOMPSON, K.:Newcastle Univ, Translat & Clin Res Inst, Newcastle Upon Tyne, Northumberland, England; Newcastle Tyne Hosp NHS Fdn Trust, NIHR Newcastle Biomed Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England
hcfmusp.author.externalHORVATH, I. Fanny:Univ Debrecen, Fac Med, Div Rheumatol, Debrecen, Hungary
hcfmusp.author.externalFARRIS, A. D.:Oklahoma Med Res Fdn, Genes & Human Dis Res Program, Oklahoma City, OK USA
hcfmusp.author.externalSIMONCELLI, E.:Sapienza Univ, Dept Internal Med & Med Specialties, Rome, Italy; St Camillus Int Univ Hlth Sci, UniCamillus, Rome, Italy
hcfmusp.author.externalBOMBARDIERI, S.:Univ Pisa, Rheumatol Unit, Pisa, Italy
hcfmusp.author.externalKILIC, L.:Hacettepe Univ, Fac Med, Dept Internal Med, Div Rheumatol, Ankara, Turkey
hcfmusp.author.externalTUFAN, A.:Gazi Univ, Sch Med, Dept Internal Med, Div Rheumatol, Ankara, Turkey
hcfmusp.author.externalPIRKMAJER, K. Perdan:Univ Med Ctr Ljubljana, Dept Rheumatol, Llubljana, Slovenia; Univ Ljubljana, Fac Med, Dept Internal Med, Ljubljana, Slovenia
hcfmusp.author.externalFUJISAWA, Y.:Kanazawa Univ Hosp, Div Rheumatol, Kanazawa, Ishikawa, Japan
hcfmusp.author.externalVITA, S. De:St Maria Misericordia Univ Hosp, Univ Udine, Inst Dermatol, Dept Expt & Clin Med, Piazzale St Maria Misericordia 15, I-33100 Udine, Italy
hcfmusp.author.externalABACAR, K.:Marmara Univ, Sch Med, Istanbul, Turkey
hcfmusp.author.externalRAMOS-CASALS, M.:Hosp Clin Barcelona, Dept Autoimmune Dis, ICMiD, Barcelona, Spain; Univ Barcelona, Dept Med, Barcelona, Spain; Hosp Clin Barcelona, Serv Malalties Autoimmunes Sistem, C Villarroel 170, Barcelona 08036, Spain
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcSANDRA GOFINET PASOTO
hcfmusp.description.beginpage2437
hcfmusp.description.endpage2447
hcfmusp.description.issue12
hcfmusp.description.volume41
hcfmusp.origemWOS
hcfmusp.origem.pubmed38019164
hcfmusp.origem.scopus2-s2.0-85181178127
hcfmusp.origem.wosWOS:001134013500012
hcfmusp.publisher.cityPISAeng
hcfmusp.publisher.countryITALYeng
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