The human vaginal microbiome

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art_LINHARES_The_human_vaginal_microbiome_2019.PDF (97.02 KB)
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4
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bookPart
Data de publicação
2019
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Scopus
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ELSEVIER
Autores
MINIS, E.
WITKIN, S. S.
Citação
Linhares, I. M.; Minis, E.; Robial, R.; Witkin, S. S.. The human vaginal microbiome. In: . MICROBIOME AND METABOLOME IN DIAGNOSIS, THERAPY, AND OTHER STRATEGIC APPLICATIONS: ELSEVIER, 2019. p.109-114.
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Resumo
Women have developed a unique vaginal microbiome, distinct from all other mammals, to prevent infection and to protect both the mother and fetus during pregnancy. Lactobacilli, predominantly L. crispatus and L. iners, are numerically dominant in the vagina, and their presence increases further during pregnancy. Their predominance may prevent other microorganisms, from adhering to the vaginal epithelium and initiating an infection. They produce lactic acid that acidifies the vagina and inhibits the growth of other microorganisms. Lactic acid also specifically inactivates a number of sexually transmitted viral and bacterial pathogens, such as human immunodeficiency virus, herpesvirus, Chlamydia trachomatis, Neisseria gonorrhoeae, and the bacteria associated with bacterial vaginosis. Lactic acid also possesses immunological properties that prevent activation of proinflammatory immunity in the vagina, while concomitantly promoting the release of antibacterial products from vaginal epithelial cells. L. crispatus also uniquely promotes vaginal health, by inducing autophagy in epithelial cells. © 2019 Elsevier Inc. All rights reserved.
Palavras-chave
Lactic acid, Lactobacillus crispatus, Lactobacillus iners, Vaginal immunology, Vaginal microbiome
URI
https://observatorio.fm.usp.br/handle/OPI/51234
Referências
  1. Witkin, S.S., Ledger, W.J., Complexities of the uniquely human vagina (2012) Sci Transl Med, 4, p. 132fs11
  2. Yildirim, S., Yeoman, J., Janga, S.C., Thomas, S.M., Ho, M., Leigh, S.R., Primate vaginal microbiomes exhibit species specificity without universal Lactobacillus dominance (2014) ISME J, 8, pp. 2431-2444
  3. Stumpf, R.M., Wilson, B.A., Rivera, A., Yildirim, S., Yeoman, C.J., Polk, J.D., The primate vaginal microbiome: Comparative context and implications for human health and disease (2013) Am J Phys Anthropol, 152, pp. 119-134
  4. Witkin, S.S., Linhares, I.M., Why do lactobacilli dominate the human vaginal microbiota? (2017) BJOG, 124, pp. 606-611
  5. Witkin, S.S., The vaginal microbiome, vaginal anti-microbial defence mechanisms and the clinical challenge of reducing infection-related preterm birth (2015) BJOG, pp. 213-219
  6. Ravel, J., Gajer, P., Abdo, Z., Schneider, G.M., Koenig, S.S.K., McCulle, S.L., Vaginal microbiome of reproductive-age women (2011) Proc Natl Acad Sci USA, 108, pp. 4680-4687
  7. Gajer, P., Brotman, R.M., Bai, G.Y., Sakamoto, J., Schuette, U.M., Zhong, X., (2012) Sci Transl Med, 4, p. 132ra52
  8. Lamont, R.R., Sobel, J.D., Akins, R.A., Hassan, S.S., Chaiworopongsa, T., Kusanovic, J.P., The vaginal microbiome: New information about genital tract flora using molecular based techniques (2011) BJOG, 118, pp. 533-549
  9. Nasioudis, D., Linhares, I.M., Ledger, W.J., Witkin, S.S., Bacterial vagnosis: A critical analysis of current knowledge (2017) BJOG, 124, pp. 61-69
  10. Atashili, J., Poole, C., Ndumbe, P.M., Adimora, A.A., Smith, J.S., Bacterial vaginosis and HIV acquisition: A meta-analysis of published studies (2008) AIDS, 22, pp. 1493-1501
  11. Gillet, E., Meys, J.F., Verstraelen, H., Bosire, C., De Sutter, P., Temmerman, M., Bacterial vaginosis is associated with uterine cervical human papillomavirus infection: A meta-analysis (2011) BMC Infect Dis, 11, p. 10
  12. Gallo, M.F., Macaluso, M., Warner, L., Fleenor, M.E., Hook, E.W., Brill, I., Bacterial vaginosis, gonorrhea, and chlamydial infection among women attending a sexually transmitted disease clinic: A longitudinal analysis of possible causal links (2012) Ann Epidemiol, 22, pp. 213-220
  13. McElligott, K.A., Havnilesky, L.J., Myers, E.R., Preoperative screening strategies for bacterial vaginosis prior to elective hysterectomy: A cost comparison study (2011) Am J Obstet Gyneol, 205, pp. 500e1-500e7
  14. Romero, R., Hassan, S.S., Gajer, P., Tarca, A.L., Fadrosh, D.W., Nikita, L., The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women (2014) Microbiome, 2, p. 4
  15. McIntyre, D.A., Chandiramoni, M., Lee, S.Y., Kindinger, L., Smith, A., Angelopoulos, N., The vaginal microbiome during pregnancy and the postpartum period in a European population (2015) Sci Rep, 5, p. 8988
  16. DiGiulio, D.B., Temporal and spatial variation of the human microbiota during pregnancy (2015) Proc Natl Acad Sci USA, 112, pp. 11060-11065
  17. Romero, R., The vaginal microbiota of pregnant women who subsequently have a spontaneous preterm labor and delivery and those with a normal delivery at term (2014) Microbiome, 2, p. 18
  18. Laxmi, U., Agrawal, S., Raghunandan, C., Randhawa, V.S., Salli, A., Association of bacterial vaginosis with adverse fetomaternal outcome in women with spontaneous preterm labor: A prospective cohort study (2012) J Matern Fetal Neonatal Med, 25, pp. 64-67
  19. Giakoumelou, S., Wheelhouse, N., Cushieri, K., Entrican, G., Howie, S.E., Howe, A.W., The role of infection in miscarriage (2016) Hum Reprod Update, 22, pp. 116-133
  20. Watts, D.H., Krohn, M.A., Hillier, S.L., Eschenbach, D.A., Bacterial vaginosis as a risk factor for post-cesarean endometritis (1990) Obstet Gynecol, 75, pp. 52-58
  21. Carey, J.C., Klebanoff, M.A., Hauth, J.C., Hillier, S.L., Thorn, E.A., Ernest, J.M., Metronidazole to prevent preterm delivery in pregnant women with asymptomatic bacterial vaginosis (2000) N Eng J Med, 342, pp. 534-540
  22. Nasioudis, D., Forney, L.J., Schneider, G.M., Gliniewicz, K., France, M., Boester, A., Influence of pregnancy history on the vaginal microbiome of pregnant women in their first trimester (2017) Sci Rep, 7, p. 10201
  23. Dominguez-Bello, M.G., Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns (2010) Proc Natl Acad Sci USA, 107, pp. 11971-11975
  24. Chu, D.M., Ma, J., Prince, A.L., Antony, K.M., Seferovic, M.D., Aagaard, K.M., Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery (2017) Nature Med, 23, pp. 314-328
  25. Boskey, E.R., Cone, R.A., Whaley, K.J., Moench, T.R., Origins of vaginal acidity: High D/L lactic acid ratio is consistent with bacteria being the primary source (2001) Hum Reprod, 16, pp. 1809-1813
  26. Witkin, S.S., Mendes-Soares, H., Linhares, I.M., Jayaram, A., Ledger, W.J., Forney, L.J., Influence of vaginal bacteria and D- and L- lactic acid isomers on vaginal extracellular matrix metalloproteinase inducer: Implications for protection against upper genital tract infections (2013) mBio, 4. , e00460-13
  27. Witkin, S.S., Lactic acid alleviates stress: Good for female genital tract homeostasis, bad for protection against malignancy (2017) Cell Stress Chaperones
  28. Galle, J.D., Bailey, M.T., Impact of stressor exposure on the interplay between commensal microbiota and host inflammation (2014) Gut Microb, 5, pp. 390-396
  29. Gravett, M.G., Witkin, S.S., Haluska, G.J., Edwards, J.L., Cook, M.J., Novy, M.J., An experimental model for intraamniotic infection and preterm labor in rhesus monkeys (1994) Am J Obstet Gynecol, 171, pp. 1660-1667
  30. Nasioudis, D., Forney, L.J., Schneider, G.M., Gliniewicz, K., France, M.T., Boester, A., The composition of the vaginal microbiome in first trimester pregnant women influences the level of autophagy and stress in vaginal epithelial cells (2017) J Reprod Immunol, 123, pp. 35-39
  31. Wang, C.-W., Klionsky, D.J., The molecular mechanism of autophagy (2003) Mol Med, 9, pp. 65-76
  32. Leizer, J., Nasioudis, D., Forney, L.J., Schneider, G.M., Gliniewicz, K., Boester, A., Properties of epithelial cells and vaginal secretions in pregnant women when Lactobacillus crispatusor Lactobacillus iners dominate the vagina microbiome (2018) Reprod Sci, 25, pp. 854-860
  33. Jasarevic, E., Howerton, C.L., Howard, C.E., Bale, T.L., Alterations in the vaginal microbiome by maternal stress are associated with metabolic reprogramming of the offspring gut and brain (2015) Endocrinol, 156, pp. 3265-3276
  34. Brosnahan, A.J., Vulchanova, L., Witta, S.R., Dai, Y., Joones, B.J., Brown, D.R., Norepinephrine potentiates proinflammatory responses of human vaginal epithelial cells (2013) J Neuroimmunol, 259, pp. 8-16
  35. Hoyme, U.B., Saling, E., Efficient prematurity prevention is possible by pH-self measurement and immediate therapy of threatening ascending infection (2004) Eur J Obstet Gynecol Reprod Biol, 115, pp. 148-153
  36. Tachedjian, G., Aldunate, M., Bradshaw, C.S., Cone, R.A., The role of lactic acid production by probiotic Lactobacillus species in vaginal health (2017) Res Microbiol
  37. Maclaim, J.M., Fernandes, A.D., DiBella, J.M., Hammond, J.A., Reid, G., Gloor, G.B., Comparative meta-RNA-seq of the vaginal microbiota and differential expression by Lactobacillus iners in health and dysbiosis (2013) Microbiome, 1, pp. 12-23
  38. Ravel, J., Brotman, R.M., Gajer, P., Ma, B., Nandy, M., Fadrosh, D.W., Daily temporal dynamics of vaginal microbiota before, during and after episodes of bacterial vaginosis (2013) Microbiome, 1, p. 29
  39. Bradshaw, C.S., Brotman, R.M., Making inroads into improving treatment of bacterial vaginosis - striving for long-term cure (2015) BMC Infect Dis, 15, p. 292
  40. Mirmonsef, P., Hotton, A.L., Gilbert, D., Burgad, D., Landay, A., Weber, K.M., Free glycogen in vaginal fluids is associated with Lactobacillus colonization and low vaginal pH (2014) PLoS One, 9, p. e102467
  41. Jaffe, S., Normand, N., Jayaram, A., Orfanelli, T., Doulaveris, G., Passos, M., Unique variation in genetic selection among Black North American women and its potential influence on pregnancy outcome (2013) Med Hypotheses, 81, pp. 919-922

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Livros e Capítulos de Livros - HC/ICHC
Livros e Capítulos de Livros - LIM/58
Livros e Capítulos de Livros - ODS/03