Core Promoter and Pre-Core Variants of the Hepatitis B Virus (HBV) Are Frequent in Chronic Hepatitis B HBeAg-Negative Patients Infected by Genotypes A and D

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorREUTER, Tania
dc.contributor.authorGOMES-GOUVEA, Michele Soares
dc.contributor.authorCHUFFI, Samira
dc.contributor.authorDUQUE, Ulisses Horst
dc.contributor.authorPERINI, Waltesia
dc.contributor.authorAZEVEDO, Raymundo Soares
dc.contributor.authorPINHO, Joao Renato Rebello
dc.contributor.authorLEWIS-XIMENEZ, Lia L.
dc.contributor.authorVILLAR, Livia Melo
dc.contributor.authorESPUL, Carlos Alberto
dc.contributor.authorPUJOL, Flor H.
dc.contributor.authorROMAN, Sonia
dc.date.accessioned2024-02-15T14:53:16Z
dc.date.available2024-02-15T14:53:16Z
dc.date.issued2023
dc.description.abstractIn Brazil, hepatitis B virus endemicity is low, moderate, or high in some areas, such as Espirito Santo State in the southeast region. In this study, we intend to characterize the basal core promoter (BCP) and pre-core region (PC) variants and their association with clinical/epidemiological disease patterns in patients infected with genotypes A and D. The study included 116 chronic hepatitis B patients from Espirito Santo State, Southeast Brazil, infected with genotypes A and D. Basal core promoter (BCP) and pre-core mutations were analyzed in these patients. The frequency of BCP and PC mutations was compared with age, HBeAg status, HBV genotype and subgenotype, HBV-DNA level, clinical classification, and transmission route. HBeAg-negative status was found in 101 (87.1%) patients: 87 (75.0%) were infected with genotype A (A1 = 85; A2 = 2) and 29 (25.0%) were infected with genotype D (D3 = 24; D4 = 3; D2 = 2). BCP + PC variants altogether were more frequent (48.1%) in genotype D than in genotype A strains (6.0%) (p < 0.001). When this evaluation was performed considering the cases that presented only the A1762T and/or G1764A (BCP) mutations, it was observed that the frequency was higher in genotype A (67.5%) compared to genotype D (7.4%) (p < 0.001). On the other hand, considering the samples with mutations only in positions G1896A and/or G1899A (PC), the frequency was higher in genotype D (75.8%) than in genotype A (6.9%) (p < 0.001). Interestingly, HBV DNA was lower than 2000 IU/mL especially when both BCP/PC mutations were present (p < 0.001) or when only PC mutations were detected (p = 0.047), reinforcing their role in viral replication.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipLIMHCFMUSP (Laboratrios de Investigao Mdica do Hospital das Clnicas da Faculdade de Medicina da USP)
dc.identifier.citationVIRUSES-BASEL, v.15, n.12, article ID 2339, 11p, 2023
dc.identifier.doi10.3390/v15122339
dc.identifier.eissn1999-4915
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/58038
dc.language.isoeng
dc.publisherMDPIeng
dc.relation.ispartofViruses-Basel
dc.rightsopenAccesseng
dc.rights.holderCopyright MDPIeng
dc.subjectchronic hepatitis Beng
dc.subjectHBVeng
dc.subjectpre core mutationseng
dc.subjectbasal core promoter mutationseng
dc.subjectBCP and PC variantseng
dc.subject.othermutationseng
dc.subject.otherbrazileng
dc.subject.wosVirologyeng
dc.titleCore Promoter and Pre-Core Variants of the Hepatitis B Virus (HBV) Are Frequent in Chronic Hepatitis B HBeAg-Negative Patients Infected by Genotypes A and Deng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalDUQUE, Ulisses Horst:Univ Fed Espirito Santo, Univ Hosp Cassiano Antonio de Moraes, Hlth Sci Ctr, Internal Med Dept, BR-29041295 Vitoria, ES, Brazil
hcfmusp.author.externalPERINI, Waltesia:Univ Fed Espirito Santo, Univ Hosp Cassiano Antonio de Moraes, Hlth Sci Ctr, Internal Med Dept, BR-29041295 Vitoria, ES, Brazil
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcTANIA QUEIROZ REUTER MOTTA
hcfmusp.contributor.author-fmusphcMICHELE SOARES GOMES GOUVEA
hcfmusp.contributor.author-fmusphcSAMIRA CHUFFI
hcfmusp.contributor.author-fmusphcRAYMUNDO SOARES DE AZEVEDO NETO
hcfmusp.contributor.author-fmusphcJOAO RENATO REBELLO PINHO
hcfmusp.description.articlenumber2339
hcfmusp.description.issue12
hcfmusp.description.volume15
hcfmusp.origemWOS
hcfmusp.origem.pubmed38140580
hcfmusp.origem.scopus2-s2.0-85180431985
hcfmusp.origem.wosWOS:001132360700001
hcfmusp.publisher.cityBASELeng
hcfmusp.publisher.countrySWITZERLANDeng
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hcfmusp.scopus.lastupdate2024-05-17
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