Impact of radiotherapy on adverse events of self-expanding metallic stents in patients with esophageal cancer
Carregando...
Citações na Scopus
0
Tipo de produção
article
Data de publicação
2023
Título da Revista
ISSN da Revista
Título do Volume
Editora
OXFORD UNIV PRESS INC
Citação
DISEASES OF THE ESOPHAGUS, v.36, n.10, 2023
Resumo
Self-expanding metallic stents (SEMS) are considered the treatment of choice for the palliation of dysphagia and fistulas in inoperable esophageal neoplasms. However, the safety of SEMSs in patients who received or who will be submitted to radiotherapy (RT) is uncertain. The study aimed to evaluate the impact of RT on adverse events (AEs) in patients with esophageal cancer with SEMSs. This is a retrospective study conducted at a tertiary cancer hospital from 2009 to 2018. We collected information regarding RT, the histological type of the tumor, the model of SEMSs and AEs after stent placement. Three hundred twenty-three patients with malignant stenosis or fistula were treated with SEMSs. The predominant histological type was squamous cell carcinoma (79.6%). A total of 282 partially covered and 41 fully covered SEMSs were inserted. Of the 323 patients, 182 did not received RT, 118 received RT before SEMS placement and 23 after. Comparing the group that received RT before stent insertion with the group that did not, the first one presented a higher frequency of severe pain (9/118 7.6% vs. 3/182 1.6%; P = 0.02). The group treated with RT after stent placement had a higher risk of global AEs (13/23 56.5% vs. 63/182 34.6%; P = 0.019), ingrowth/overgrowth (6/23 26.1% vs. 21/182 11.5%; P = 0.045) and gastroesophageal reflux (2/23 8.7% vs. 2/182 1.1%; P = 0.034). Treatment with RT before stent placement in patients with inoperable esophageal neoplasm prolongs survival and is associated with an increased risk of severe chest pain. Treatment with RT of patients with an esophageal stent increases the frequency of minor, not life-threatening AEs.
Palavras-chave
esophageal cancer, esophageal stent, radiotherapy
Referências
- Abou-Jawde RM, 2005, CHEST, V128, P250, DOI 10.1378/chest.128.1.250
- Abu Dayyeh BK, 2013, ENDOSCOPY, V45, P42, DOI 10.1055/s-0032-1325960
- AlSarraf M, 1997, J CLIN ONCOL, V15, P277, DOI 10.1200/JCO.1997.15.1.277
- Bethge N, 1996, GASTROINTEST ENDOSC, V43, P596, DOI 10.1016/S0016-5107(96)81592-6
- Bick BL, 2013, GASTROINTEST ENDOSC, V77, P181, DOI 10.1016/j.gie.2012.10.004
- Chen YK, 2011, GASTROINTEST ENDOSC, V73, P1109, DOI 10.1016/j.gie.2011.02.001
- CWIKIEL W, 1993, RADIOLOGY, V187, P667, DOI 10.1148/radiology.187.3.8497612
- Martins BD, 2013, ENDOSCOPY, V45, pE342, DOI 10.1055/s-0033-1344129
- Didden P, 2012, GASTROINTEST ENDOSC, V76, P426, DOI 10.1016/j.gie.2012.03.004
- Eroglu A, 2016, TURK GOGUS KALP DAMA, V24, P703, DOI 10.5606/tgkdc.dergisi.2016.4456
- Evans JA, 2013, GASTROINTEST ENDOSC, V77, P328, DOI 10.1016/j.gie.2012.10.001
- Francis SR, 2017, INT J RADIAT ONCOL, V99, P884, DOI 10.1016/j.ijrobp.2017.06.2457
- Fuccio L, 2016, GASTROINTEST ENDOSC, V83, P746, DOI 10.1016/j.gie.2015.08.047
- Gergel TJ, 2002, CANCER J, V8, P451, DOI 10.1097/00130404-200211000-00009
- Homs MYV, 2004, EUR J GASTROEN HEPAT, V16, P163, DOI 10.1097/00042737-200402000-00007
- Ribeiro MSI, 2018, GASTROINTEST ENDOSC, V87, P390, DOI 10.1016/j.gie.2017.09.020
- Jalaj S., 2014, NUTR DIABETES, V79
- Javed Amit, 2012, J Gastrointest Cancer, V43, P63, DOI 10.1007/s12029-010-9206-4
- Jiang XJ, 2012, WORLD J GASTROENTERO, V18, P1404, DOI 10.3748/wjg.v18.i12.1404
- Kinsman KJ, 1996, GASTROINTEST ENDOSC, V43, P196
- Lai A, 2018, DIGEST DIS SCI, V63, P1025, DOI 10.1007/s10620-018-4957-z
- Lecleire S, 2006, ALIMENT PHARM THER, V23, P1693, DOI 10.1111/j.1365-2036.2006.02946.x
- Li XA, 2002, INT J RADIAT ONCOL, V54, P1276, DOI 10.1016/S0360-3016(02)03803-8
- Lu YF, 2018, ONCOLOGIST, V23, P1426, DOI 10.1634/theoncologist.2017-0646
- Maccioni F., 1991, J VASC INTERV RADIOL, V181
- Martins B, 2012, ENDOSCOPY, V44, pE10, DOI 10.1055/s-0031-1291496
- Medeiros VS, 2017, GASTROINTEST ENDOSC, V86, P299, DOI 10.1016/j.gie.2016.12.017
- Nagaraja V, 2014, J GASTROINTEST ONCOL, V5, P119, DOI 10.3978/j.issn.2078-6891.2014.007
- Nishimura Y, 2003, INT J RADIAT ONCOL, V56, P1327, DOI 10.1016/S0360-3016(03)00198-6
- OKEN MM, 1982, AM J CLIN ONCOL-CANC, V5, P649, DOI 10.1097/00000421-198212000-00014
- Park JJ, 2010, DIGEST LIVER DIS, V42, P436, DOI 10.1016/j.dld.2009.07.020
- Penniment MG, 2018, LANCET GASTROENTEROL, V3, P114, DOI 10.1016/S2468-1253(17)30363-1
- Power C, 2007, DIS ESOPHAGUS, V20, P466, DOI 10.1111/j.1442-2050.2007.00696.x
- Qiu G, 2013, DIS ESOPHAGUS, V26, P175, DOI 10.1111/j.1442-2050.2012.01348.x
- Reijm AN, 2019, ENDOSCOPY, V51, P18, DOI 10.1055/a-0644-2495
- Song HY, 2002, J VASC INTERV RADIOL, V13, P285, DOI 10.1016/S1051-0443(07)61722-9
- Spaander MCW, 2016, ENDOSCOPY, V48, P939, DOI 10.1055/s-0042-114210
- Sumiyoshi T, 2003, GASTROINTEST ENDOSC, V57, P882, DOI 10.1016/S0016-5107(03)70024-8
- UMSAWASDI T, 1985, INT J RADIAT ONCOL, V11, P511, DOI 10.1016/0360-3016(85)90182-8
Coleções
Artigos e Materiais de Revistas Científicas - FM/MGT
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/07
Artigos e Materiais de Revistas Científicas - LIM/24
Artigos e Materiais de Revistas Científicas - LIM/35
Carregar mais Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/07
Artigos e Materiais de Revistas Científicas - LIM/24
Artigos e Materiais de Revistas Científicas - LIM/35