Assessing the safety and use of medicinal herbs during pregnancy: a cross-sectional study in São Paulo, Brazil

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art_IM_Assessing_the_safety_and_use_of_medicinal_herbs_2023.PDF (745.08 KB)
Citações na Scopus
1
Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
FRONTIERS MEDIA SA
Autores
IM, Hyea Bin
HWANG, Jung Hye
CHOI, Dain
KUNWOR, Sangita Karki
MORAES, Sandra Dircinha Teixeira de Araujo
HAN, Dongwoon
Citação
FRONTIERS IN PHARMACOLOGY, v.14, article ID 1268185, 14p, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: Despite the lack of evidence supporting the safety and clinical efficacy of herbal medicine (HM), its use among pregnant women continues to increase. Given the high prevalence of contraindicated herbs among the pregnant population in Brazil, it is crucial to examine the use of HM and evaluate its safety based on the current scientific literature to ensure that women are using HM appropriately.Methods: A cross-sectional study was conducted from October 2022 to January 2023 at a public teaching hospital in Sao Paulo, Brazil. A total of 333 postpartum women in the postnatal wards and postnatal clinic were interviewed using a semi-structured questionnaire. The survey instrument consisted of 51 items covering the use of HM during pregnancy, sociodemographic and health-related characteristics, COVID-19 experiences, and pregnancy outcomes. For data analysis, chi-square and multivariate logistic regression were conducted using SPSS ver. 26.0.Results: Approximately 20% of respondents reported using HM during their most recent pregnancy, with a higher use observed among women from ethnic minority groups and those with prior HM experience. Among the 20 medicinal herbs identified, 40% were found to be contraindicated or recommended for use with caution during pregnancy. However, only half of the women discussed their HM use with obstetric care providers.Conclusion: This study emphasizes the continued public health concern regarding the use of contraindicated or potentially harmful HM among pregnant women in Brazil, highlighting the need for sustained efforts to reduce the risk of inappropriate HM use. By updating antenatal care guidelines based on the latest scientific evidence, healthcare providers can make informed clinical decisions and effectively monitor pregnant women's HM use, ultimately promoting safer and more effective healthcare practices.
Palavras-chave
herbal medicine, safety classification, pregnant women, cross-sectional study, Brazil
URI
https://observatorio.fm.usp.br/handle/OPI/57739
Referências
  1. Aalami-Harandi R, 2015, J MATERN-FETAL NEO M, V28, P2020, DOI 10.3109/14767058.2014.977248
  2. Abdollahi F, 2019, WOMEN HEALTH, V59, P579, DOI 10.1080/03630242.2017.1421285
  3. Agu JC, 2019, J IMMIGR MINOR HEALT, V21, P1137, DOI 10.1007/s10903-018-0832-4
  4. Ahmed M, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.926449
  5. Ahmed M, 2020, BMC COMPLEMENT MED, V20, DOI 10.1186/s12906-020-03142-9
  6. Ahmed M, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2399-y
  7. Ahmed M, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1995-6
  8. Al-Ramahi R, 2013, J ETHNOPHARMACOL, V150, P79, DOI 10.1016/j.jep.2013.07.041
  9. Al-Snafi A. E., 2023, GSC Biol. Pharm. Sci, V22, P079, DOI [10.30574/gscbps.2023.22.2.0477, DOI 10.30574/GSCBPS.2023.22.2.0477]
  10. [Anonymous], 1997, Botanical safety handbook
  11. Aryunisari C. G., 2021, Open Access Maced. J. Med. Sci, V9, P720, DOI [10.3889/oamjms.2021.6424, DOI 10.3889/OAMJMS.2021.6424]
  12. Bakare A. A., 2012, Int. J. Med. Med. Sci, V2, P1
  13. Balbontín YM, 2019, OBSTET GYNECOL, V133, P920, DOI 10.1097/AOG.0000000000003217
  14. Basch Ethan M., 2005, Natural Standard Herb & Supplement Handbook: The Clinical Bottom Line
  15. Borrelli F, 2007, MOL NUTR FOOD RES, V51, P1386, DOI 10.1002/mnfr.200700072
  16. Brah AS, 2023, INT J FOOD PROP, V26, P301, DOI 10.1080/10942912.2022.2158864
  17. Casagrande A., 2023, Ethnobot. Res. Appl, V25, P1, DOI [10.32859/era.25.35.1-34, DOI 10.32859/ERA.25.35.1-34]
  18. Cuzzolin L, 2010, PHARMACOEPIDEM DR S, V19, P1151, DOI 10.1002/pds.2040
  19. da Matta R, 2021, B LATINOAM CARIBE PL, V20, P71, DOI 10.37360/blacpma.21.20.1.6
  20. Dove D, 1999, J NURSE-MIDWIFERY, V44, P320, DOI 10.1016/S0091-2182(99)00055-5
  21. Eid AM, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00046
  22. Ekpenyong CE., 2014, J Pharmacogn Phytochem, V3, P133
  23. El Hajj M, 2020, COMPLEMENT THER CLIN, V40, DOI 10.1016/j.ctcp.2020.101218
  24. El Hajj M, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00866
  25. El Mihyaoui A, 2022, LIFE-BASEL, V12, DOI 10.3390/life12040479
  26. Ezeabara C. A., 2014, Int. J. Trop. Dis. Health, V4, P1044, DOI [10.9734/ijtdh/2014/11481, DOI 10.9734/IJTDH/2014/11481]
  27. de Araújo CRF, 2016, REV BRAS GINECOL OBS, V38, P127, DOI 10.1055/s-0036-1580714
  28. Fong Harry H S, 2002, Integr Cancer Ther, V1, P287
  29. Frawley J, 2014, J ALTERN COMPLEM MED, V20, P571, DOI 10.1089/acm.2014.0028
  30. Ribot DG, 2020, DIABETES-METAB RES, V36, DOI 10.1002/dmrr.3349
  31. Hall HR, 2014, MIDWIFERY, V30, P499, DOI 10.1016/j.midw.2013.06.001
  32. Hasan Syed Shahzad, 2009, Complement Ther Clin Pract, V15, P152, DOI 10.1016/j.ctcp.2009.02.003
  33. Heinrich M, 2015, BRIT J CLIN PHARMACO, V80, P62, DOI 10.1111/bcp.12586
  34. Heitmann K, 2013, EUR J CLIN PHARMACOL, V69, P269, DOI 10.1007/s00228-012-1331-5
  35. Hoffmann D., 2017, Healthy digestion: A natural approach to relieving indigestion, gas, heartburn, constipation, colitis, and more
  36. Hwang JH, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1167-0
  37. Illamola SM, 2020, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01483
  38. Indriyani NN, 2023, FOODS, V12, DOI 10.3390/foods12102036
  39. Islahudin F, 2017, PATIENT PREFER ADHER, V11, P913, DOI 10.2147/PPA.S132282
  40. Jahan S, 2022, HELIYON, V8, DOI 10.1016/j.heliyon.2022.e08854
  41. James PB, 2018, BMJ GLOB HEALTH, V3, DOI 10.1136/bmjgh-2018-000895
  42. James PB, 2018, WOMEN BIRTH, V31, pE302, DOI 10.1016/j.wombi.2017.12.006
  43. John Lisha J, 2015, Oman Med J, V30, P229, DOI 10.5001/omj.2015.48
  44. Kalder M, 2011, ARCH GYNECOL OBSTET, V283, P475, DOI 10.1007/s00404-010-1388-2
  45. Kaur J., 2013, Am J Phytomed Clin Ther, V1, P226
  46. Kennedy DA, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1079-z
  47. Kennedy DA, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-355
  48. Kia PY, 2014, IRAN RED CRESCENT ME, V16, DOI 10.5812/ircmj.14360
  49. Lee SM, 2018, GUT PATHOG, V10, DOI 10.1186/s13099-018-0244-y
  50. Luo L, 2021, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.595335
  51. Mahboubi Mohaddese, 2019, J Menopausal Med, V25, P1, DOI 10.6118/jmm.2019.25.1.1
  52. Mahmoudian Alireza, 2012, Zhong Xi Yi Jie He Xue Bao, V10, P424, DOI 10.3736/jcim20120411
  53. Marcus DM, 2005, OBSTET GYNECOL, V105, P1119, DOI 10.1097/01.AOG.0000158858.79134.ea
  54. Boccolini PDM, 2022, BMC COMPLEMENT MED, V22, DOI 10.1186/s12906-022-03687-x
  55. Boccolini PDM, 2020, BMC COMPLEMENT MED, V20, DOI 10.1186/s12906-020-2842-8
  56. Moreira R. R. D., 2014, J. Gen. Pract, P1, DOI [10.4172/2329-9126.1000190, DOI 10.4172/2329-9126.1000190]
  57. Narang Nithithep, 2016, Pharmacogn Rev, V10, P118, DOI 10.4103/0973-7847.194043
  58. Nundy S., 2016, Sir ganga ram hospital health series: Heartburn and reflux oesophagitis-e-book
  59. Nyeko R, 2016, BMC PREGNANCY CHILDB, V16, DOI 10.1186/s12884-016-1095-5
  60. Okem A, 2014, S AFR J BOT, V93, P125, DOI 10.1016/j.sajb.2014.04.001
  61. Okoro B. C., 2023, Pharmacol. Res.-Mod. Chin, V8, P100273, DOI [10.1016/j.prmcm.2023.100273, DOI 10.1016/J.PRMCM.2023.100273]
  62. Pallivalappila AR, 2014, EUR J OBSTET GYN R B, V181, P251, DOI 10.1016/j.ejogrb.2014.08.017
  63. Rahmawati R. S. N., 2018, J. IDAMAN (Induk Pemberdaya. Masy. Pedesaan), V2, P92
  64. Ramadhani Z. N., 2020, Syst. Rev. Pharm, V11, P1930
  65. Ray J, 2018, J TAIBAH UNIV MED SC, V13, P384, DOI 10.1016/j.jtumed.2018.04.001
  66. Sahidur M., 2023, Food Chem. Adv, P100353, DOI [10.1016/j.focha.2023.100353, DOI 10.1016/J.FOCHA.2023.100353]
  67. Sarecka-Hujar B, 2022, PHARMACEUTICS, V14, DOI 10.3390/pharmaceutics14010171
  68. Saude S. D. E. D., 2002, Resolucao-SES/RJ N 1757 de 18/02/2002
  69. Series B., 2008, National policy on integrative and complementary practices of the SUS
  70. Shafreen RB, 2018, J LUMIN, V201, P115, DOI 10.1016/j.jlumin.2018.04.010
  71. Smeriglio A, 2014, PHYTOTHER RES, V28, P1107, DOI 10.1002/ptr.5106
  72. Souza CDM, 2023, J HERB MED, V41, DOI 10.1016/j.hermed.2023.100691
  73. Sridharan S, 2009, ULTRASOUND OBST GYN, V34, P358, DOI 10.1002/uog.6453
  74. Taavoni Simin, 2011, Complement Ther Clin Pract, V17, P167, DOI 10.1016/j.ctcp.2010.10.003
  75. Tafesh Z. Q., 2021, Journal of Applied Pharmaceutical Science, V11, P144, DOI 10.7324/JAPS.2021.110117
  76. Tapasvi S., 2023, Int. J. Orthop, V9, P587, DOI [10.22271/ortho.2023.v9.i1h.3346, DOI 10.22271/ORTHO.2023.V9.I1H.3346]
  77. Terzioglu Bebitoglu Berna, 2020, Medeni Med J, V35, P55, DOI 10.5222/MMJ.2020.69851
  78. Trabace L, 2015, J ETHNOPHARMACOL, V174, P396, DOI 10.1016/j.jep.2015.08.046
  79. Viljoen E, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-20
  80. Yao M, 2007, J ETHNOPHARMACOL, V113, P204, DOI 10.1016/j.jep.2007.05.028
  81. Zhang JH, 2012, COMPLEMENT THER MED, V20, P100, DOI 10.1016/j.ctim.2011.09.004

Coleções
Artigos e Materiais de Revistas Científicas - LIM/26
Artigos e Materiais de Revistas Científicas - COVID-19
Artigos e Materiais de Revistas Científicas - HC/ICr
Artigos e Materiais de Revistas Científicas - LIM/58
Artigos e Materiais de Revistas Científicas - ODS/03