Upper Airway Mucociliary Clearance is Impaired in Dyspneic COVID-19 Patients
Carregando...
Citações na Scopus
0
Tipo de produção
article
Data de publicação
2023
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER INDIA
Autores
DAVID, Andrea Goldwasser
BOGGI, Alexandre Coelho
MELO, Bruna
ROSALINO, Claudia Maria Valete
RODRIGUEZ, Athenea Pascual
THAMBOO, Andrew
Citação
INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY, v.75, n.2, p.772-776, 2023
Resumo
Covid-19 is transmitted mainly by respiratory droplets and as the upper airway mucosa is the first innate immune barrier, it is crucial to understand the effects of SARS-CoV-2 on this system. In the current study, we aimed to evaluate the nasal mucociliary clearance in patients with SARS-CoV-2 infection and their symptom development. Observational cross-sectional study. The nasal mucociliary clearance (NMC) time was evaluated by the saccharin test and the results were compared between patients with SARS-CoV-2 infection (group 1) and controls (group 2, asymptomatic patients with a negative polymerase chain reaction test). We also compared the NMC time for each specific symptom suffered by participants in group 1 with the NMC time of the control group as well as with the patients in group 1 who were asymptomatic. There was a significant increase in NMC time in group 1 with dyspnea when compared to the control group (p = 0.032) and also when compared to patients who were infected were not dyspneic (p = 0.04). There were no differences in the clearance times when considering other symptoms. COVID-19 patients with dyspnea present with altered nasal mucociliary clearance.
Palavras-chave
COVID-19, SARS-CoV-2, Mucociliary clearance, Anosmia, Saccharin
Referências
- Baig AM, 2020, ACS CHEM NEUROSCI, V11, P995, DOI 10.1021/acschemneuro.0c00122
- Bunyavanich S, 2020, JAMA-J AM MED ASSOC, V323, P2427, DOI 10.1001/jama.2020.8707
- Caponnetto P, 2021, ENT-EAR NOSE THROAT, DOI 10.1177/01455613211064044
- Cordeiro TG, 2021, RHINOLOGY, V59, P267, DOI 10.4193/Rhin21.002
- Santos JGD, 2022, J ORAL BIOSCI, V64, P108, DOI 10.1016/j.job.2022.01.007
- Glezer I, 2019, HAND CLINIC, V164, P67, DOI 10.1016/B978-0-444-63855-7.00005-8
- Gordon David E, 2020, bioRxiv, DOI 10.1101/2020.03.22.002386
- Jakobsen L, 2011, EMBO J, V30, P1520, DOI 10.1038/emboj.2011.63
- Joffily L, 2020, BRAZ J OTORHINOLAR, V86, P632, DOI 10.1016/j.bjorl.2020.05.002
- Kahraman ME, 2021, ACTA OTO-LARYNGOL, V141, P989, DOI 10.1080/00016489.2021.1991592
- Kamani T, 2006, LARYNGOSCOPE, V116, P586, DOI 10.1097/01.MLG.0000205608.50526.28
- Kumar A, 2013, PROTOPLASMA, V250, P965, DOI 10.1007/s00709-013-0488-9
- Li W, 2020, FEBS J, V287, P3672, DOI 10.1111/febs.15491
- Mao L, 2020, NEUROLOGICAL MANIFES, DOI 10.1001/jamaneurol.2020.1127
- Pallanti S, 2020, COMPR PSYCHIAT, V100, DOI 10.1016/j.comppsych.2020.152184
- Pezato R, 2012, MED HYPOTHESES, V78, P468, DOI 10.1016/j.mehy.2012.01.006
- Reiter JF, 2017, NAT REV MOL CELL BIO, V18, P533, DOI 10.1038/nrm.2017.60
- Rodrigues F, 2019, INT ARCH OTORHINOLAR, V23, P229, DOI 10.1055/s-0038-1676116
- STANLEY P, 1984, BRIT J DIS CHEST, V78, P62, DOI 10.1016/0007-0971(84)90098-6
- Xu K, 2020, Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, V55, P313, DOI 10.3760/cma.j.cn115330-20200201-00240