Exposure to air pollution as an environmental determinant of how Sjögren's disease is expressed at diagnosis

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBRITO-ZERON, P.
dc.contributor.authorFLORES-CHAVEZ, A.
dc.contributor.authorNG, W. -F.
dc.contributor.authorHORVATH, I. Fanny
dc.contributor.authorRASMUSSEN, A.
dc.contributor.authorPRIORI, R.
dc.contributor.authorBALDINI, C.
dc.contributor.authorARMAGAN, B.
dc.contributor.authorOZKIZILTAS, B.
dc.contributor.authorPRAPROTNIK, S.
dc.contributor.authorSUZUKI, Y.
dc.contributor.authorQUARTUCCIO, L.
dc.contributor.authorHERNANDEZ-MOLINA, G.
dc.contributor.authorABACAR, K.
dc.contributor.authorBARTOLONI, E.
dc.contributor.authorRISCHMUELLER, M.
dc.contributor.authorOLIVEIRA, F. Reis-de
dc.contributor.authorTREVISANI, V. Fernandes Moca
dc.contributor.authorJURCUT, C.
dc.contributor.authorFUGMANN, C.
dc.contributor.authorCARUBBI, F.
dc.contributor.authorHOFAUER, B.
dc.contributor.authorVALIM, V.
dc.contributor.authorPASOTO, S. G.
dc.contributor.authorRETAMOZO, S.
dc.contributor.authorATZENI, F.
dc.contributor.authorFONSECA-AIZPURU, E.
dc.contributor.authorLOPEZ-DUPLA, M.
dc.contributor.authorGIACOMELLI, R.
dc.contributor.authorNAKAMURA, H.
dc.contributor.authorAKASBI, M.
dc.contributor.authorTHOMPSON, K.
dc.contributor.authorSZANTO, A.
dc.contributor.authorFARRIS, A. D.
dc.contributor.authorVILLA, M.
dc.contributor.authorBOMBARDIERI, S.
dc.contributor.authorKILIC, L.
dc.contributor.authorTUFAN, A.
dc.contributor.authorPIRKMAJER, K. Perdan
dc.contributor.authorFUJISAWA, Y.
dc.contributor.authorVITA, S. De
dc.contributor.authorINANC, N.
dc.contributor.authorRAMOS-CASALS, M.
dc.contributor.groupauthorSjogren Big Data Consortium
dc.date.accessioned2024-02-15T14:55:56Z
dc.date.available2024-02-15T14:55:56Z
dc.date.issued2023
dc.description.abstractObjectiveTo analyse how the potential exposure to air pollutants can influence the key components at the time of diagnosis of Sjogren's phenotype (epidemiological profile, sicca symptoms, and systemic disease). MethodsFor the present study, the following variables were selected for harmonisation and refinement: age, sex, country, fulfilment of 2002/2016 criteria items, dry eyes, dry mouth, and overall ESSDAI score. Air pollution indexes per country were defined according to the OECD (1990-2021), including emission data of nitrogen and sulphur oxides (NO/SO), particulate matter (PM2.5 and 1.0), carbon monoxide (CO) and volatile organic compounds (VOC) calculated per unit of GDP, Kg per 1000 USD.ResultsThe results of the chi-square tests of independence for each air pollutant with the frequency of dry eyes at diagnosis showed that, except for one, all variables exhibited p-values <0.0001. The most pronounced disparities emerged in the dry eye prevalence among individuals inhabiting countries with the highest NO/SO exposure, a surge of 4.61 percentage points compared to other countries, followed by CO (3.59 points), non-methane (3.32 points), PM2.5 (3.30 points), and PM1.0 (1.60 points) exposures. Concerning dry mouth, individuals residing in countries with worse NO/SO exposures exhibited a heightened frequency of dry mouth by 2.05 percentage points (p<0.0001), followed by non-methane exposure (1.21 percentage points increase, p=0.007). Individuals inhabiting countries with the worst NO/SO, CO, and PM2.5 pollution levels had a higher mean global ESSDAI score than those in lower-risk nations (all p-values <0.0001). When systemic disease was stratified according to DAS into low, moderate, and high systemic activity levels, a heightened proportion of individuals manifesting moderate/severe systemic activity was observed in countries with worse exposures to NO/SO, CO, and PM2.5 pollutant levels. ConclusionFor the first time, we suggest that pollution levels could influence how SjD appears at diagnosis in a large international cohort of patients. The most notable relationships were found between symptoms (dryness and general body symptoms) and NO/SO, CO, and PM2.5 levels.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [303116/2022-6]
dc.identifier.citationCLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v.41, n.12, p.2448-2457, 2023
dc.identifier.eissn1593-098X
dc.identifier.issn0392-856X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/58222
dc.language.isoeng
dc.publisherCLINICAL & EXPER RHEUMATOLOGYeng
dc.relation.ispartofClinical and Experimental Rheumatology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright CLINICAL & EXPER RHEUMATOLOGYeng
dc.subjectSjogren's syndromeeng
dc.subjectdrynesseng
dc.subjectsystemiceng
dc.subjectESSDAIeng
dc.subjectair pollutioneng
dc.subjectenvironmenteng
dc.subject.othersjogrens-syndromeeng
dc.subject.wosRheumatologyeng
dc.titleExposure to air pollution as an environmental determinant of how Sjögren's disease is expressed at diagnosiseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEspanha
hcfmusp.affiliation.countryInglaterra
hcfmusp.affiliation.countryHungria
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryItália
hcfmusp.affiliation.countryEslovênia
hcfmusp.affiliation.countryJapão
hcfmusp.affiliation.countryMéxico
hcfmusp.affiliation.countryAustrália
hcfmusp.affiliation.countryRomênia
hcfmusp.affiliation.countrySuécia
hcfmusp.affiliation.countryÁustria
hcfmusp.affiliation.countryisoes
hcfmusp.affiliation.countryisogb
hcfmusp.affiliation.countryisohu
hcfmusp.affiliation.countryisous
hcfmusp.affiliation.countryisoit
hcfmusp.affiliation.countryisosi
hcfmusp.affiliation.countryisojp
hcfmusp.affiliation.countryisomx
hcfmusp.affiliation.countryisoau
hcfmusp.affiliation.countryisoro
hcfmusp.affiliation.countryisose
hcfmusp.affiliation.countryisoat
hcfmusp.author.externalBRITO-ZERON, P.:Sanitas Digital Hosp, Hosp CIMA Ctr Med Milenium Balmes Sanitas, Autoimmune Dis Unit, Res & Innovat Grp Autoimmune Dis, Barcelona, Spain
hcfmusp.author.externalFLORES-CHAVEZ, A.:Hosp Clin Barcelona, Dept Autoimmune Dis, ICMiD, Barcelona, Spain
hcfmusp.author.externalNG, W. -F.:United Kingdom Primary Sjogrens Syndrome Registry, Newcastle NIHR Biomed Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England
hcfmusp.author.externalHORVATH, I. Fanny:Univ Debrecen, Fac Med, Div Clin Immunol, Debrecen, Hungary
hcfmusp.author.externalRASMUSSEN, A.:Oklahoma Med Res Fdn, Genes & Human Dis Res Program, Oklahoma City, OK USA
hcfmusp.author.externalPRIORI, R.:Sapienza Univ Rome, Dept Internal Med & Med Specialties, Rheumatol Clin, Rome, Italy; St Camillus Int Univ Hlth Sci, UniCamillus, Rome, Italy
hcfmusp.author.externalBALDINI, C.:Univ Pisa, Rheumatol Unit, Pisa, Italy
hcfmusp.author.externalARMAGAN, B.:Hacettepe Univ, Fac Med, Dept Internal Med, Div Rheumatol, Ankara, Turkiye
hcfmusp.author.externalOZKIZILTAS, B.:Gazi Univ, Sch Med, Dept Internal Med, Div Rheumatol, Ankara, Turkiye
hcfmusp.author.externalPRAPROTNIK, S.:Univ Med Ctr Ljubljana, Dept Rheumatol, Llubljana, Slovenia
hcfmusp.author.externalSUZUKI, Y.:Kanazawa Univ Hosp, Div Rheumatol, Kanazawa, Ishikawa, Japan
hcfmusp.author.externalQUARTUCCIO, L.:Univ Udine, Univ Hosp Santa Maria della Misericordia, Dept Med, Div Rheumatol, Udine, Italy
hcfmusp.author.externalHERNANDEZ-MOLINA, G.:Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Immunol & Rheumatol Dept, Mexico City, DF, Mexico
hcfmusp.author.externalABACAR, K.:Marmara Univ, Sch Med, Istanbul, Turkiye
hcfmusp.author.externalBARTOLONI, E.:Univ Perugia, Dept Med, Rheumatol Unit, Perugia, Italy
hcfmusp.author.externalRISCHMUELLER, M.:Univ Adelaide, Queen Elizabeth Hosp, Discipline Med, Dept Rheumatol, Adelaide, SA, Australia
hcfmusp.author.externalOLIVEIRA, F. Reis-de:Univ Sao Paulo, Ribeirao Preto Med Sch, Clin Hosp, Ribeirao Preto, Brazil
hcfmusp.author.externalTREVISANI, V. Fernandes Moca:Univ Fed Sao Paulo, Div Hlth Based Evidence, Sao Paulo, Brazil
hcfmusp.author.externalJURCUT, C.:Carol Davila Cent Mil Emergency Hosp, Dept Internal Med, Bucharest, Romania
hcfmusp.author.externalFUGMANN, C.:Uppsala Univ, Dept Med Sci, Rheumatol, Uppsala, Sweden
hcfmusp.author.externalCARUBBI, F.:San Salvatore Hosp, Internal Med & Nephrol Unit, ASL Avezzano Sulmona LAquila, Dept Med, Laquila, Italy
hcfmusp.author.externalHOFAUER, B.:Med Univ Innsbruck, Otorhinolaryngol Head & Neck Surg, Innsbruck, Austria
hcfmusp.author.externalVALIM, V.:Univ Fed Espirito Santo, Vitoria, Spain
hcfmusp.author.externalRETAMOZO, S.:Hosp Quiron Salud, Dept Rheumatol, Barcelona, Spain
hcfmusp.author.externalATZENI, F.:IRCCS Galeazzi Orthopaed Inst, Milan, Italy; Univ Messina, Rheumatol Unit, Messina, Italy
hcfmusp.author.externalFONSECA-AIZPURU, E.:Hosp Cabuenes, Dept Internal Med, Gijon, Spain
hcfmusp.author.externalLOPEZ-DUPLA, M.:Hosp Joan 23, Dept Internal Med, Tarragona, Spain
hcfmusp.author.externalGIACOMELLI, R.:Univ Rome Campus Biomed, Clin Unit Rheumatol & Clin Immunol, Rome, Italy
hcfmusp.author.externalNAKAMURA, H.:Nihon Univ, Dept Med, Div Haematol & Rheumatol, Sch Med, Oyaguchi Kami Cho,Itabashi Ku, Tokyo, Japan
hcfmusp.author.externalAKASBI, M.:Hosp Infanta Leonor, Dept Internal Med, Madrid, Spain
hcfmusp.author.externalTHOMPSON, K.:United Kingdom Primary Sjogrens Syndrome Registry, Newcastle NIHR Biomed Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England
hcfmusp.author.externalSZANTO, A.:Univ Debrecen, Fac Med, Div Clin Immunol, Debrecen, Hungary
hcfmusp.author.externalFARRIS, A. D.:Oklahoma Med Res Fdn, Arthrit & Clin Immunol Program, Oklahoma City, OK USA
hcfmusp.author.externalVILLA, M.:Sapienza Univ Rome, Dept Internal Med & Med Specialties, Rheumatol Clin, Rome, Italy; St Camillus Int Univ Hlth Sci, UniCamillus, Rome, Italy
hcfmusp.author.externalBOMBARDIERI, S.:Univ Pisa, Rheumatol Unit, Pisa, Italy
hcfmusp.author.externalKILIC, L.:Hacettepe Univ, Fac Med, Dept Internal Med, Div Rheumatol, Ankara, Turkiye
hcfmusp.author.externalTUFAN, A.:Gazi Univ, Sch Med, Dept Internal Med, Div Rheumatol, Ankara, Turkiye
hcfmusp.author.externalPIRKMAJER, K. Perdan:Univ Med Ctr Ljubljana, Dept Rheumatol, Llubljana, Slovenia; Univ Ljubljana, Fac Med, Dept Internal Med, Ljubljana, Slovenia
hcfmusp.author.externalFUJISAWA, Y.:Kanazawa Univ Hosp, Div Rheumatol, Kanazawa, Ishikawa, Japan
hcfmusp.author.externalVITA, S. De:Univ Udine, Univ Hosp Santa Maria della Misericordia, Dept Med, Div Rheumatol, Udine, Italy
hcfmusp.author.externalINANC, N.:Marmara Univ, Sch Med, Istanbul, Turkiye
hcfmusp.author.externalRAMOS-CASALS, M.:Hosp Clin Barcelona, Dept Autoimmune Dis, ICMiD, Barcelona, Spain; Univ Barcelona, Dept Med, Barcelona, Spain
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcSANDRA GOFINET PASOTO
hcfmusp.description.beginpage2448
hcfmusp.description.endpage2457
hcfmusp.description.issue12
hcfmusp.description.volume41
hcfmusp.origemWOS
hcfmusp.origem.pubmed38019154
hcfmusp.origem.scopus2-s2.0-85181176271
hcfmusp.origem.wosWOS:001134013500010
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