COVID-19 induces more pronounced extracellular matrix deposition than other causes of ARDS

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCOSTA, Natalia de Souza Xavier
dc.contributor.authorRIBEIRO JUNIOR, Gabriel
dc.contributor.authorNASCIMENTO, Ellen Caroline Toledo do
dc.contributor.authorBRITO, Jose Mara de
dc.contributor.authorANTONANGELO, Leila
dc.contributor.authorFARIA, Caroline Silverio
dc.contributor.authorMONTEIRO, Jhonatas Sirino
dc.contributor.authorSETUBAL, Joao Carlos
dc.contributor.authorPINHO, Joao Renato Rebello
dc.contributor.authorPEREIRA, Roberta Verciano
dc.contributor.authorSEELAENDER, Marilia
dc.contributor.authorCASTRO, Gabriela Salim de
dc.contributor.authorLIMA, Joanna D. C. C.
dc.contributor.authorMONTEIRO, Renata Aparecida de Almeida
dc.contributor.authorDUARTE-NETO, Amaro Nunes
dc.contributor.authorSALDIVA, Paulo Hilario Nascimento
dc.contributor.authorSILVA, Luiz Fernando Ferraz da
dc.contributor.authorDOLHNIKOFF, Marisa
dc.contributor.authorMAUAD, Thais
dc.date.accessioned2023-12-15T18:56:25Z
dc.date.available2023-12-15T18:56:25Z
dc.date.issued2023
dc.description.abstractBackgroundLung fibrosis is a major concern in severe COVID-19 patients undergoing mechanical ventilation (MV). Lung fibrosis frequency in post-COVID syndrome is highly variable and even if the risk is proportionally small, many patients could be affected. However, there is still no data on lung extracellular matrix (ECM) composition in severe COVID-19 and whether it is different from other aetiologies of ARDS.MethodsWe have quantified different ECM elements and TGF-beta expression in lung tissue of 28 fatal COVID-19 cases and compared to 27 patients that died of other causes of ARDS, divided according to MV duration (up to six days or seven days or more). In COVID-19 cases, ECM elements were correlated with lung transcriptomics and cytokines profile.ResultsWe observed that COVID-19 cases presented significant increased deposition of collagen, fibronectin, versican, and TGF-beta, and decreased decorin density when compared to non-COVID-19 cases of similar MV duration. TGF-beta was precociously increased in COVID-19 patients with MV duration up to six days. Lung collagen was higher in women with COVID-19, with a transition of upregulated genes related to fibrillogenesis to collagen production and ECM disassembly along the MV course.ConclusionsFatal COVID-19 is associated with an early TGF-beta expression lung environment after the MV onset, followed by a disordered ECM assembly. This uncontrolled process resulted in a prominent collagen deposition when compared to other causes of ARDS. Our data provides pathological substrates to better understand the high prevalence of pulmonary abnormalities in patients surviving COVID-19.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico [401825/2020-5, 304277/2019-3]
dc.description.sponsorshipBill and Melinda Gates Foundation [INV 002396]
dc.description.sponsorshipHospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, HC Convida [HC-02.18/2020]
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo [2020/10281-0]
dc.identifier.citationRESPIRATORY RESEARCH, v.24, n.1, article ID 281, 11p, 2023
dc.identifier.doi10.1186/s12931-023-02555-7
dc.identifier.eissn1465-993X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/57525
dc.language.isoeng
dc.publisherBMCeng
dc.relation.ispartofRespiratory Research
dc.rightsopenAccesseng
dc.rights.holderCopyright BMCeng
dc.subjectCOVID-19eng
dc.subjectLung fibrosiseng
dc.subjectExtracellular matrixeng
dc.subjectAutopsyeng
dc.subject.otherrespiratory-distress-syndromeeng
dc.subject.otherversicaneng
dc.subject.otherdecorineng
dc.subject.wosRespiratory Systemeng
dc.titleCOVID-19 induces more pronounced extracellular matrix deposition than other causes of ARDSeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalBRITO, Jose Mara de:Univ Sao Paulo, Dept Patol LIM 05, Dept Gastroenterol LIM 07, Fac Med, Sao Paulo, Brazil
hcfmusp.author.externalMONTEIRO, Jhonatas Sirino:Univ Sao Paulo, Ctr Biol Marinha, BR-11600000 Sao Sebastiao, Brazil
hcfmusp.author.externalSETUBAL, Joao Carlos:Univ Sao Paulo, Dept Bioquim, Inst Quim, Sao Paulo, Brazil
hcfmusp.author.externalLIMA, Joanna D. C. C.:Univ Sao Paulo, Canc Metab Res Grp, Sao Paulo, Brazil; Univ Sao Paulo, Hosp Clin, Dept Surg & LIM 26, Sao Paulo, Brazil
hcfmusp.citation.scopus2
hcfmusp.contributor.author-fmusphcNATALIA DE SOUZA XAVIER COSTA
hcfmusp.contributor.author-fmusphcGABRIEL RIBEIRO JUNIOR
hcfmusp.contributor.author-fmusphcELLEN CAROLINE TOLEDO DO NASCIMENTO
hcfmusp.contributor.author-fmusphcLEILA ANTONANGELO
hcfmusp.contributor.author-fmusphcCAROLINE SILVERIO FARIA
hcfmusp.contributor.author-fmusphcJOAO RENATO REBELLO PINHO
hcfmusp.contributor.author-fmusphcROBERTA VERCIANO PEREIRA YOKOGAWA
hcfmusp.contributor.author-fmusphcMARILIA CERQUEIRA LEITE SEELAENDER
hcfmusp.contributor.author-fmusphcGABRIELA SALIM FERREIRA DE CASTRO
hcfmusp.contributor.author-fmusphcRENATA APARECIDA DE ALMEIDA MONTEIRO
hcfmusp.contributor.author-fmusphcAMARO NUNES DUARTE NETO
hcfmusp.contributor.author-fmusphcPAULO HILARIO NASCIMENTO SALDIVA
hcfmusp.contributor.author-fmusphcLUIZ FERNANDO FERRAZ DA SILVA
hcfmusp.contributor.author-fmusphcMARISA DOLHNIKOFF
hcfmusp.contributor.author-fmusphcTHAIS MAUAD
hcfmusp.description.articlenumber281
hcfmusp.description.issue1
hcfmusp.description.volume24
hcfmusp.origemWOS
hcfmusp.origem.pubmed37964271
hcfmusp.origem.scopus2-s2.0-85176391813
hcfmusp.origem.wosWOS:001101277200005
hcfmusp.publisher.cityLONDONeng
hcfmusp.publisher.countryENGLANDeng
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Artigos e Materiais de Revistas Científicas - COVID-19
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