Cardiac autonomic modulation in children with severe liver disease, before and after liver transplantation

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art_SALATINI_Cardiac_autonomic_modulation_in_children_with_severe_liver_2022.PDF (411.69 KB)
Citações na Scopus
1
Tipo de produção
article
Data de publicação
2022
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
AME PUBL CO
Autores
SALATINI, Renata
RAIMUNDO, Rodrigo Daminello
ROCHA, Fernando
ABREU, Luiz Carlos de
MORAIS, Mauro
Citação
TRANSLATIONAL PEDIATRICS, v.11, n.4, p.438-447, 2022
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: The cardiovascular system is directly influenced by the autonomic nervous system (ANS); its changes affect heart rate variability (HRV) and are sensitive indicators of physiological changes. Autonomic dysfunction (AD) is manifested in up to 60% of patients with cirrhosis. Therefore, we aim to analyze the indexes of HRV pre- and post-surgery of children submitted for liver transplantation (LT). Methods: HRV, in children of both genders from 6 months of age to 10 years, that attended at the pediatric surgery clinic in the queue for LT at the Children's Institute were analyzed. To access HRV we analyzed indexes such as standard deviation of the RR intervals (SDNN), root-mean-square of the successive normal sinus RR interval difference (RMSSD), low frequency (LF), high frequency (NF), and LF/HF. Results: The analysis of the behavior of cardiac autonomic modulation, in the period prior to LT and after surgery, showed an increase in HRV linear parameters SDNN, TINN (triangular interpolation of NN interval histogram), HFms(2). In the time domain, there was also an increase in the HFms(2) index. Conclusions: The analysis of the period preceding LT and two months after surgery showed an increase in the HRV linear parameters representing a global HRV improvement. In the time domain, there was also an increase in the HFms(2) index, parasympathetic tone of the HRV.
Palavras-chave
Autonomic nervous system (ANS), liver diseases, child, heart rate variability (HRV), liver transplantation (LT)
URI
https://observatorio.fm.usp.br/handle/OPI/47194
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPE
Artigos e Materiais de Revistas Científicas - HC/ICr
Artigos e Materiais de Revistas Científicas - HC/IMREA
Artigos e Materiais de Revistas Científicas - LIM/30