Handicap as a Measure of Perceived-Health Status in Parkinson's Disease

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article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
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ISSN da Revista
Título do Volume
Editora
WILEY
Autores
SILVA, Daniela Pimenta
COELHO, Miguel
SOARES, Tiago
VALE, Thiago Cardoso
GUEDES, Leonor Correia
MACIEL, Ricardo Oliveira Horta
ANTUNES, Ana Patricia
CAMARGOS, Sarah Teixeira
VALADAS, Anabela
GODINHO, Catarina
Citação
MOVEMENT DISORDERS CLINICAL PRACTICE, v.10, n.8, p.1172-1180, 2023
Projetos de Pesquisa
Unidades Organizacionais
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Resumo
BackgroundHandicap is a patient-centered measure of health status that encompasses the impact of social and physical environment on daily living, having been assessed in advanced and late-stage Parkinson's Disease (PD). ObjectiveTo characterize the handicap of a broader sample of patients. MethodsA cross-sectional study of 405 PD patients during the MDS-UPDRS Portuguese validation study, using the MDS-UPDRS, Unified Dyskinesias Rating Scale, Nonmotor symptoms questionnaire, PDQ-8 and EQ-5D-3L. Handicap was measured using the London Handicap Scale (LHS). ResultsMean age was 64.42 (& PLUSMN;10.3) years, mean disease duration 11.30 (& PLUSMN;6.5) years and median HY 2 (IQR, 2-3). Mean LHS was 0.652 (& PLUSMN;0.204); ""Mobility,"" ""Occupation"" and ""Physical Independence"" were the most affected domains. LHS was significantly worse in patients with longer disease duration, older age and increased disability. In contrast, PDQ-8 did not differentiate age groups. Handicap was significantly correlated with disease duration (r = -0.35), nonmotor experiences of daily living (EDL) (MDS-UPDRS-I) (r = -0.51), motor EDL (MDS-UPDRS-II) (r = -0.69), motor disability (MDS-UPDRS-III) (r = -0.49), axial signs of MDS-UPDRS-III (r = -0.55), HY (r = -0.44), presence of nonmotor symptoms (r = -0.51) and PDQ-8 index (r = -0.64) (all P < 0.05). Motor EDL, MDS-UPDRS-III and PDQ-8 independently predicted Handicap (adjusted R-2 = 0.582; P = 0.007). ConclusionsThe LHS was easily completed by patients and caregivers. Patients were mild-moderately handicapped, which was strongly determined by motor disability and its impact on EDL, and poor QoL. Despite correlated, handicap and QoL seem to differ in what they measure, and handicap may have an added value to QoL. Handicap seems to be a good measure of perceived-health status in a broad sample of PD.
Palavras-chave
Parkinson's disease, London handicap scale, health-related quality of life, patient-centred outcome measure
URI
https://observatorio.fm.usp.br/handle/OPI/58233
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Coleções
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/45
Artigos e Materiais de Revistas Científicas - LIM/62