Pre-transplant multidrug-resistant infections in liver transplant recipients-epidemiology and impact on transplantation outcome
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Tipo de produção
article
Data de publicação
2024
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY
Citação
CLINICAL TRANSPLANTATION, v.38, n.1, article ID e15173, 10p, 2024
Resumo
Background Cirrhotic patients are highly exposed to healthcare services and antibiotics. Although pre-liver transplantation (LT) infections are directly related to the worsening of liver function, the impact of these infections on LT outcomes is still unclear. This study aimed to identify the effect of multidrug-resistant microorganism (MDRO) infections before LT on survival after LT.Methods Retrospective study that included patients who underwent LT between 2010 and 2019. Variables analyzed were related to patients' comorbidities, underlying diseases, time on the waiting list, antibiotic use, LT surgery, and occurrences post-LT. Multivariate analyses were performed using logistic regression, and Cox regression for survival analysis.Results A total of 865 patients were included; 351 infections were identified in 259 (30%) patients, of whom 75 (29%) had >= 1 pre-LT MDRO infection. The most common infection was spontaneous bacterial peritonitis (34%). The agent was identified in 249(71%), 53(15%) were polymicrobial. The most common microorganism was Klebsiella pneumoniae (18%); the most common MDRO was ESBL-producing Enterobacterales (16%), and carbapenem-resistant (CR) Enterobacterales (10%). Factors associated with MDRO infections before LT were previous use of therapeutic cephalosporin (p = .001) and fluoroquinolone (p = .001), SBP prophylaxis (p = .03), ACLF before LT (p = .03), and days of hospital stay pre-LT (p < .001); HCC diagnosis was protective (p = .01). Factors associated with 90-day mortality after LT were higher MELD on inclusion to the waiting list (p = .02), pre-LT MDRO infection (p = .04), dialysis after LT (p < .001), prolonged duration of LT surgery (p < .001), post-LT CR-Gram-negative bacteria infection (p < .001), and early retransplantation (p = .004).Conclusion MDRO infections before LT have an important impact on survival after LT.
Palavras-chave
carbapenem resistance, dialysis, Enterobacterales, ESBL-producing, meld, mortality, retransplantation, risk factors
Referências
- Baganate F, 2018, SURGERY, V164, P694, DOI 10.1016/j.surg.2018.04.039
- Baijal R, 2014, INDIAN J GASTROENTER, V33, P336, DOI 10.1007/s12664-014-0461-3
- Bartoletti M, 2018, CLIN MICROBIOL INFEC, V24, DOI 10.1016/j.cmi.2017.08.001
- Bert F, 2012, EMERG INFECT DIS, V18, P908, DOI 10.3201/eid1806.110139
- Biggins SW, 2021, HEPATOLOGY, V74, P1014, DOI 10.1002/hep.31884
- CDC/NHSN, CDC NHSN SURV DEF SP
- Chiang DN, 2022, TRANSPL INFECT DIS, V24, DOI 10.1111/tid.13821
- Cinar G, 2019, TRANSPL P, V51, P2461, DOI 10.1016/j.transproceed.2019.02.050
- European Assoc Study Liver, 2018, J HEPATOL, V69, P406, DOI 10.1016/j.jhep.2018.03.024
- Fernández J, 2019, J HEPATOL, V70, P398, DOI 10.1016/j.jhep.2018.10.027
- Ferstl PG, 2017, LIVER INT, V37, P1488, DOI 10.1111/liv.13438
- Freire MP, 2021, INFECT DIS-NOR, V53, P430, DOI 10.1080/23744235.2021.1887511
- Freire MP, 2022, TRANSPL INFECT DIS, V24, DOI 10.1111/tid.13920
- Freire MP, 2017, TRANSPLANTATION, V101, P811, DOI [10.1097/TP.0000000000001620, 10.1097/tp.0000000000001620]
- Giannella M, 2021, CLIN INFECT DIS, V73, pE955, DOI 10.1093/cid/ciab109
- Gupta T, 2020, J GASTROEN HEPATOL, V35, P461, DOI 10.1111/jgh.14788
- Heldman MR, 2019, TRANSPL INFECT DIS, V21, DOI 10.1111/tid.13152
- Leibovici-Weissman Y, 2021, TRANSPL INFECT DIS, DOI 10.1111/tid.13673
- Lin KH, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0072893
- Magiorakos AP, 2012, CLIN MICROBIOL INFEC, V18, P268, DOI 10.1111/j.1469-0691.2011.03570.x
- Magro B, 2021, LIVER TRANSPLANT, V27, P43, DOI 10.1002/lt.25897
- Moon HH, 2018, TRANSPL P, V50, P2668, DOI 10.1016/j.transproceed.2018.03.040
- Onorato L, 2022, ANTIBIOTICS-BASEL, V11, DOI 10.3390/antibiotics11020232
- Piano S, 2021, CLIN MOL HEPATOL, V27, P437, DOI 10.3350/cmh.2020.0329
- Piano S, 2021, CLIN LIVER DIS, V25, P357, DOI 10.1016/j.cld.2021.01.006
- Piano S, 2019, GASTROENTEROLOGY, V156, P1368, DOI 10.1053/j.gastro.2018.12.005
- Russell DL, 2008, AM J TRANSPLANT, V8, P1737, DOI 10.1111/j.1600-6143.2008.02304.x
- Salerno F, 2017, LIVER INT, V37, P71, DOI 10.1111/liv.13195
- Salvalaggio P, 2012, EINSTEIN-SAO PAULO, V10, P278, DOI 10.1590/S1679-45082012000300004
- Sun HY, 2010, LIVER TRANSPLANT, V16, P222, DOI 10.1002/lt.21982
- Taimur S, 2021, CLIN TRANSPLANT, V35, DOI 10.1111/ctr.14239
- Trebicka J, 2021, J HEPATOL, V75, pS67, DOI 10.1016/j.jhep.2020.11.013
- Weinstein MP., 2020, PERFORMANCE STANDARD
- Zhang WL, 2020, ANN TRANSPL, V25, DOI 10.12659/AOT.921591
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Artigos e Materiais de Revistas Científicas - FM/MGT
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