Same-Day Initiation of Oral Pre-Exposure Prophylaxis is High Among Adolescent Men Who Have Sex With Men and Transgender Women in Brazil

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSOARES, Fabiane
dc.contributor.authorMAGNO, Laio
dc.contributor.authorPINTO JR., Jony Arrais
dc.contributor.authorGRANGEIRO, Alexandre
dc.contributor.authorBRUXVOORT, Katia
dc.contributor.authorGRECO, Dirceu
dc.contributor.authorDOURADO, Ines
dc.date.accessioned2024-02-15T14:53:57Z
dc.date.available2024-02-15T14:53:57Z
dc.date.issued2023
dc.description.abstractPurpose: This study analyzed the sociodemographic and behavioral characteristics of adolescent men who have sex with men (aMSM) and transgender women (aTGW) initiating oral pre-exposure prophylaxis (PrEP) in human immunodeficiency virus (HIV) prevention clinics. Methods: PrEP1519 is a prospective, multicenter, open-label PrEP demonstration cohort study of aMSM and aTGWaged 15-19 years living in three large Brazilian capital cities. For this analysis, we included adolescents who enrolled in PrEP1519 from February 2019 to August 2021. Adolescents who visited PrEP clinics were classified into four groups based on PrEP eligibility and on their decision to use PrEP: (1) ineligible for same-day PrEP initiation; (2) eligible for same-day PrEP initiation, initiated PrEP at first visit; (3) eligible for PrEP initiation, initiated PrEP after the first visit; and (4) eligible for same-day PrEP initiation but declined. The groups that were eligible for same-day PrEP initiation were compared using the Chi-square and Fisher's exact tests. Results: Of the 1,254 adolescents enrolled in the PrEP1519 study, 61 (4.9%) were considered ineligible for same-day PrEP initiation. Of the 1,193 eligible for same-day PrEP initiation, 1,113 (93.3%) initiated PrEP [1,054 initiated PrEP in the first visit (88.3%) and 59 in subsequent visits (4.9%)] and 80 (6.7%) did not. Despite 90% of the PrEP decliners reporting a low risk of HIV infection, most reported condomless anal sex in the past six months (70%). Discussion: Same-day PrEP initiation among aMSM and aTGW was high, highlighting that this strategy was important to promote PrEP initiation among adolescents with increased vulnerability to HIV in Brazil. (c) 2023 Society for Adolescent Health and Medicine.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipUnitaid [2017-15-FIOTECPrEP]
dc.identifier.citationJOURNAL OF ADOLESCENT HEALTH, v.73, n.6, suppl.S, p.S26-S32, 2023
dc.identifier.doi10.1016/j.jadohealth.2023.09.002
dc.identifier.eissn1879-1972
dc.identifier.issn1054-139X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/58092
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INCeng
dc.relation.ispartofJournal of Adolescent Health
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright ELSEVIER SCIENCE INCeng
dc.subjectPrEPeng
dc.subjectPreventioneng
dc.subjectHIVeng
dc.subjectAdolescentseng
dc.subjectMen who have sex with meneng
dc.subjectTransgender womeneng
dc.subject.otherhiveng
dc.subject.otherriskeng
dc.subject.otheryoungeng
dc.subject.otherepidemiologyeng
dc.subject.othercohorteng
dc.subject.wosPsychology, Developmentaleng
dc.subject.wosPublic, Environmental & Occupational Healtheng
dc.subject.wosPediatricseng
dc.titleSame-Day Initiation of Oral Pre-Exposure Prophylaxis is High Among Adolescent Men Who Have Sex With Men and Transgender Women in Brazileng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalSOARES, Fabiane:Univ Fed Bahia, Inst Saude Colet, Salvador, BA, Brazil
hcfmusp.author.externalMAGNO, Laio:Univ Estado Bahia, Dept Ciencias Vida, Salvador, BA, Brazil
hcfmusp.author.externalPINTO JR., Jony Arrais:Univ Fed Fluminense, Inst Matemat Estat, Rio De Janeiro, RJ, Brazil
hcfmusp.author.externalBRUXVOORT, Katia:Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL USA
hcfmusp.author.externalGRECO, Dirceu:Univ Fed Minas Gerais, Dept Clin Med, Fac Med, Belo Horizonte, MG, Brazil
hcfmusp.author.externalDOURADO, Ines:Univ Fed Bahia, Inst Saude Colet, Salvador, BA, Brazil
hcfmusp.citation.scopus2
hcfmusp.contributor.author-fmusphcALEXANDRE DOMINGUES GRANGEIRO
hcfmusp.description.beginpageS26
hcfmusp.description.endpageS32
hcfmusp.description.issue6
hcfmusp.description.issuesuppl S
hcfmusp.description.volume73
hcfmusp.origemWOS
hcfmusp.origem.pubmed37953005
hcfmusp.origem.scopus2-s2.0-85175549611
hcfmusp.origem.wosWOS:001105994800004
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.publisher.countryUSAeng
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hcfmusp.scopus.lastupdate2024-05-17
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