Natural Progression of Keratoconus

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Tipo de produção
bookPart
Data de publicação
2022
DOI
Scopus
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Título do Volume
Editora
SPRINGER INTERNATIONAL PUBLISHING
Autores
Citação
Santhiago, M. R.. Natural Progression of Keratoconus. In: . Keratoconus: A Comprehensive Guide to Diagnosis and Treatment: SPRINGER INTERNATIONAL PUBLISHING, 2022. p.13-18.
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Resumo
Keratoconus is an asymmetrical and progressive bilateral corneal ectasia that usually begins in the second decade of life. The inflammatory process’s role in the corneal structural changes present in keratoconus has already been described by quantifying altered levels of inflammatory cytokines in the tear film. It is known that changes in the maximum keratometry value are significantly correlated with changes in the central and thinnest thickness of the cornea and the thinnest epithelial thickness. In general, the steepening and stromal thinning are accompanied by epithelial thinning at the keratoconus’ apex in its natural progression. In conclusion, we realize that many metrics are helpful in monitoring keratoconus. Progressions in 1 year above 1D of Kmax, 0.7 Kmean, thinning of 10 in the thinnest pachymetry, myopic variation in the SE of 0.75D, or loss of two or more lines of vision suggest advancement beyond the natural history, and corneal crosslinking (CXL) is recommended to interrupt the progression if vision is 20/25 or worse. Besides, it is advised to consider CXL in patients under 18 years of age at diagnosis, given the progression speed in this group, if the vision is 20/25 or worse. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.
Palavras-chave
Asymmetry, Ectasia, Keratoconus, Steepening, Thinning
URI
https://observatorio.fm.usp.br/handle/OPI/57235
Referências
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