Mesencephalic Locomotor Region and Presynaptic Inhibition during Anticipatory Postural Adjustments in People with Parkinson's Disease

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Citações na Scopus
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Tipo de produção
article
Data de publicação
2024
DOI
Scopus
Web of Science
PubMed
Dimensions
Título da Revista
ISSN da Revista
Título do Volume
Editora
MDPI
Autores
SILVA-BATISTA, Carla
LIRA, Jumes
COELHO, Daniel Boari
LIMA-PARDINI, Andrea Cristina de
MATTOS, Eugenia Casella Tavares
MAGALHAES, Fernando Henrique
TEIXEIRA, Luis Augusto
Citação
BRAIN SCIENCES, v.14, n.2, article ID 178, 18p, 2024
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Individuals with Parkinson's disease (PD) and freezing of gait (FOG) have a loss of presynaptic inhibition (PSI) during anticipatory postural adjustments (APAs) for step initiation. The mesencephalic locomotor region (MLR) has connections to the reticulospinal tract that mediates inhibitory interneurons responsible for modulating PSI and APAs. Here, we hypothesized that MLR activity during step initiation would explain the loss of PSI during APAs for step initiation in FOG (freezers). Freezers (n = 34) were assessed in the ON-medication state. We assessed the beta of blood oxygenation level-dependent signal change of areas known to initiate and pace gait (e.g., MLR) during a functional magnetic resonance imaging protocol of an APA task. In addition, we assessed the PSI of the soleus muscle during APA for step initiation, and clinical (e.g., disease duration) and behavioral (e.g., FOG severity and APA amplitude for step initiation) variables. A linear multiple regression model showed that MLR activity (R2 = 0.32, p = 0.0006) and APA amplitude (R2 = 0.13, p = 0.0097) explained together 45% of the loss of PSI during step initiation in freezers. Decreased MLR activity during a simulated APA task is related to a higher loss of PSI during APA for step initiation. Deficits in central and spinal inhibitions during APA may be related to FOG pathophysiology.
Palavras-chave
mesencephalic locomotor region, anticipatory postural adjustment, presynaptic inhibition, freezers, step initiation, H-reflex
URI
https://observatorio.fm.usp.br/handle/OPI/58852
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MDR