Prevalence and clinical characteristics of oral lesions in heart transplant patients induced by sirolimus and everolimus: a systematic review and meta-analysis on a global scale

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMOURA, Anne Evelyn Oliveira
dc.contributor.authorBESSELER, Mariana Oliveira
dc.contributor.authorPEREZ-DE-OLIVEIRA, Maria Eduarda
dc.contributor.authorNORMANDO, Ana Gabriela Costa
dc.contributor.authorNEVES, Itamara Lucia Itagiba
dc.contributor.authorNEVES, Ricardo Simoes
dc.contributor.authorVARGAS, Pablo Agustin
dc.contributor.authorAZEKA, Estela
dc.contributor.authorSANTOS-SILVA, Alan Roger
dc.contributor.authorMONTANO, Tania Cristina Pedroso
dc.date.accessioned2024-04-05T19:46:24Z
dc.date.available2024-04-05T19:46:24Z
dc.date.issued2024
dc.description.abstractObjective. Sirolimus (SRL) and everolimus (EVL) are increasingly included in immunosuppressive protocols after heart transplantation. They present some side effects, including the appearance of painful lesions in the oral cavity. Therefore, this systematic review aimed to verify the global prevalence and clinical characteristics of oral lesions induced by SRL and EVL in heart transplant patients.Study Design. A systematic review was performed using 5 main electronic databases (Medline/PubMed, SCOPUS, EMBASE, Web of Science, and LILACS), in addition to the gray literature. Studies were independently assessed by 2 reviewers based on established eligibility criteria. The risk of bias was assessed using the Joanna Briggs Institute appraisal tools, and the certainty of evidence was evaluated through GRADE assessment.Results. Seventeen studies (860 patients) were included in the qualitative analysis. Of these, 11 studies were pooled in a metaanalysis of prevalence. The worldwide prevalence of oral lesions induced by SRL and EVL in heart transplant patients was 10.0%, and most lesions were described as ulcers >1.0 cm, related to significant pain.Conclusions. Oral lesions induced by SRL and/or EVL, although not very prevalent, have a relevant impact on patient's lives and the continuity of treatment.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexScopus
dc.description.indexDimensions
dc.description.indexWoS
dc.identifier.citationORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, v.137, n.1, p.37-52, 2024
dc.identifier.doi10.1016/j.oooo.2023.09.009
dc.identifier.eissn2212-4411
dc.identifier.issn2212-4403
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/59290
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INCeng
dc.relation.ispartofOral Surgery Oral Medicine Oral Pathology Oral Radiology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright ELSEVIER SCIENCE INCeng
dc.subject.othermammalian targeteng
dc.subject.otherrenal recoveryeng
dc.subject.otherrecipientseng
dc.subject.otherimmunosuppressioneng
dc.subject.otherstomatitiseng
dc.subject.otherinhibitorseng
dc.subject.otherconversioneng
dc.subject.otherrapamycineng
dc.subject.otherexperienceeng
dc.subject.othermanagementeng
dc.subject.wosDentistry, Oral Surgery & Medicineeng
dc.titlePrevalence and clinical characteristics of oral lesions in heart transplant patients induced by sirolimus and everolimus: a systematic review and meta-analysis on a global scaleeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalMOURA, Anne Evelyn Oliveira:Univ Estadual Campinas, UNICAMP, Oral Diag Dept, Semiol & Oral Pathol Areas,Piracicaba Dent Sch, Sao Paulo, Brazil
hcfmusp.author.externalBESSELER, Mariana Oliveira:Univ Estadual Campinas, UNICAMP, Oral Diag Dept, Semiol & Oral Pathol Areas,Piracicaba Dent Sch, Sao Paulo, Brazil
hcfmusp.author.externalPEREZ-DE-OLIVEIRA, Maria Eduarda:Univ Estadual Campinas, UNICAMP, Oral Diag Dept, Semiol & Oral Pathol Areas,Piracicaba Dent Sch, Sao Paulo, Brazil
hcfmusp.author.externalNORMANDO, Ana Gabriela Costa:Univ Estadual Campinas, UNICAMP, Oral Diag Dept, Semiol & Oral Pathol Areas,Piracicaba Dent Sch, Sao Paulo, Brazil
hcfmusp.author.externalNEVES, Itamara Lucia Itagiba:Univ Sao Paulo HCFMUSP, Hosp Clin, Med Sch, Dent Unit,Inst Corcao InCor, Sao Paulo, Brazil
hcfmusp.author.externalNEVES, Ricardo Simoes:Univ Sao Paulo HCFMUSP, Hosp Clin, Med Sch, Dent Unit,Inst Corcao InCor, Sao Paulo, Brazil
hcfmusp.author.externalVARGAS, Pablo Agustin:Univ Estadual Campinas, UNICAMP, Oral Diag Dept, Semiol & Oral Pathol Areas,Piracicaba Dent Sch, Sao Paulo, Brazil
hcfmusp.author.externalSANTOS-SILVA, Alan Roger:Univ Estadual Campinas, UNICAMP, Oral Diag Dept, Semiol & Oral Pathol Areas,Piracicaba Dent Sch, Sao Paulo, Brazil
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcESTELA AZEKA
hcfmusp.contributor.author-fmusphcTANIA CRISTINA PEDROSO MONTANO
hcfmusp.description.beginpage37
hcfmusp.description.endpage52
hcfmusp.description.issue1
hcfmusp.description.volume137
hcfmusp.origemWOS
hcfmusp.origem.dimensionspub.1164619174
hcfmusp.origem.pubmed37925270
hcfmusp.origem.scopus2-s2.0-85176209491
hcfmusp.origem.wosWOS:001140744800001
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.publisher.countryUSAeng
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relation.isAuthorOfPublication.latestForDiscovery3e6d7783-8e31-4526-b701-d929fe08ba09
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