T1/T2-weighted ratio: A feasible MRI biomarker in multiple sclerosis

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Citações na Scopus
0
Tipo de produção
article
Data de publicação
2024
DOI
Scopus
Web of Science
PubMed
Dimensions
Título da Revista
ISSN da Revista
Título do Volume
Editora
SAGE PUBLICATIONS LTD
Autores
SASTRE-GARRIGA, Jaume
ROVIRA, Alex
PARETO, Deborah
Citação
MULTIPLE SCLEROSIS JOURNAL, v.30, n.3, p.283-291, 2024
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
T1/T2-weighted ratio is a novel magnetic resonance imaging (MRI) biomarker based on conventional sequences, related to microstructural integrity and with increasing use in multiple sclerosis (MS) research. Different from other advanced MRI techniques, this method has the advantage of being based on routinely acquired MRI sequences, a feature that enables analysis of retrospective cohorts with considerable clinical value. This article provides an overview of this method, describing the previous cross-sectional and longitudinal findings in the main MS clinical phenotypes and in different brain tissues: focal white matter (WM) lesions, normal-appearing white matter (NAWM), cortical gray matter (GM), and deep normal-appearing gray matter (NAGM). We also discuss the clinical associations, possible reasons for conflicting results, correlations with other MRI-based measures, and histopathological associations. We highlight the limitations of the biomarker itself and the methodology of each study. Finally, we update the reader on its potential use as an imaging biomarker in research.
Palavras-chave
Biomarker, magnetic resonance imaging, multiple sclerosis, T1/T2-weighted ratio
URI
https://observatorio.fm.usp.br/handle/OPI/59223
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Coleções
Artigos e Materiais de Revistas Científicas - HC/InRad